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  • Hindawi Limited  (5)
  • 1
    Online Resource
    Online Resource
    Efficacy of Lipid Nanoparticle-Loaded Sorafenib Combined with Hepatic Artery Chemoembolization in the Treatment of Primary Hepatocellular Carcinoma Complicated with Microvascular Invasion
    Hindawi Limited ; 2022
    In:  Disease Markers Vol. 2022 ( 2022-5-20), p. 1-9
    Details
    In: Disease Markers, Hindawi Limited, Vol. 2022 ( 2022-5-20), p. 1-9
    Abstract: This work was to evaluate the therapeutic effect of lipid nanoparticle-loaded sorafenib combined with transcatheter artery chemoembolization (TACE) in patients with primary hepatocellular carcinoma (HC) complicated with microvascular invasion (MVI). In this work, 102 patients with primary HC combined with MVI after radical resection were divided into 4 groups according to different treatment methods. Experimental group 1 was treated with lipid nanoparticle-loaded sorafenib combined with TACE treatment group; experimental group 2 was treated with lipid nanoparticle-loaded sorafenib treatment group; experimental group 3 was TACE treatment group; control group was postoperative routine nursing group. Sorafenib lipid nanoparticles were prepared. The basic information, operation, MVI degree, tumor recurrence, and survival time of patients in each group were recorded and compared to evaluate the therapeutic effect of combined way. No great difference was found in MVI grade, average age, sex ratio, preoperative tumor markers, tumor size, number of patients with liver cirrhosis, operation time, and intraoperative bleeding among the four groups ( P 〉 0.05 ). In addition, the tumor free survival time (TFST), overall survival time (OST), and postoperative 1-year and 2-year survival rates of patients in test group 1 were greatly higher than those in single mode treatment group and control group ( P 〈 0.05 ). In summary, sorafenib nanoparticles combined with TACE can improve the survival status of patients after resection and delay the time of postoperative tumor recurrence.
    Type of Medium: Online Resource
    ISSN: 1875-8630 , 0278-0240
    URL: Article
    DOI: 10.1155/2022/4996471
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2033253-1
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  • 2
    Online Resource
    Online Resource
    Characterization, Expression, and Ligand Binding of LGP2 and MDA5 in Largemouth Black Bass Micropterus salmoides (Lacepède, 1802)
    Hindawi Limited ; 2023
    In:  Aquaculture Research Vol. 2023 ( 2023-6-15), p. 1-9
    Details
    In: Aquaculture Research, Hindawi Limited, Vol. 2023 ( 2023-6-15), p. 1-9
    Abstract: Melanoma differentiation-associated gene 5 (MDA5) and the laboratory of genetics and physiology 2 (LGP2) are family members of retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs), which play important roles in the immune response against pathogens invasion. In the present study, MDA5 and LGP2 genes were identified in largemouth bass (Micropterus salmoides), a fish species with a great economic value. The two proteins contained similar conserved domains and motifs as their counterparts of other vertebrates, including the DExDc domain (the DEAD/DEAH box helicases domain), HELICc domain (helicases superfamily domain), and regulatory domain (RD). Real-time qPCR revealed that the two genes were constitutively expressed in tissues of healthy fish and could be induced in the spleen by polyinosinic and polycytidylic acid (polyI:C) challenge in vivo. Also, selective pressure analysis revealed that the negative selection had roles in the evolutions of the two genes. Furthermore, the dsRNA binding mechanism of msLGP2 and msMDA5 were analyzed by the molecular docking strategy. The amino acids of msLGP2 involved in dsRNA binding were V604, N663, L682, and L684, which were located in the regulatory domain (RD) of msLGP2. The amino acids of msMDA5 involved in dsRNA binding were G429, H434, L842, and L845, which were located in the DExDc domain and the RD domain of msMDA5. These results indicated that fish LGP2 and MDA5 might share similar functions and ligand binding mechanism as their mammalian counterparts.
    Type of Medium: Online Resource
    ISSN: 1365-2109 , 1355-557X
    URL: Article
    DOI: 10.1155/2023/1222592
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2023
    detail.hit.zdb_id: 2207423-5
    detail.hit.zdb_id: 1227359-4
    detail.hit.zdb_id: 2019895-4
    SSG: 21,3
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  • 3
    Online Resource
    Online Resource
    Metabolism: A Novel Shared Link between Diabetes Mellitus and Alzheimer’s Disease
    Hindawi Limited ; 2020
    In:  Journal of Diabetes Research Vol. 2020 ( 2020-01-30), p. 1-12
    Details
    In: Journal of Diabetes Research, Hindawi Limited, Vol. 2020 ( 2020-01-30), p. 1-12
    Abstract: As a chronic metabolic disease, diabetes mellitus (DM) is broadly characterized by elevated levels of blood glucose. Novel epidemiological studies demonstrate that some diabetic patients have an increased risk of developing dementia compared with healthy individuals. Alzheimer’s disease (AD) is the most frequent cause of dementia and leads to major progressive deficits in memory and cognitive function. Multiple studies have identified an increased risk for AD in some diabetic populations, but it is still unclear which diabetic patients will develop dementia and which biological characteristics can predict cognitive decline. Although few mechanistic metabolic studies have shown clear pathophysiological links between DM and AD, there are several plausible ways this may occur. Since AD has many characteristics in common with impaired insulin signaling pathways, AD can be regarded as a metabolic disease. We conclude from the published literature that the body’s diabetic status under certain circumstances such as metabolic abnormalities can increase the incidence of AD by affecting glucose transport to the brain and reducing glucose metabolism. Furthermore, due to its plentiful lipid content and high energy requirement, the brain’s metabolism places great demands on mitochondria. Thus, the brain may be more susceptible to oxidative damage than the rest of the body. Emerging evidence suggests that both oxidative stress and mitochondrial dysfunction are related to amyloid- β (A β ) pathology. Protein changes in the unfolded protein response or endoplasmic reticulum stress can regulate A β production and are closely associated with tau protein pathology. Altogether, metabolic disorders including glucose/lipid metabolism, oxidative stress, mitochondrial dysfunction, and protein changes caused by DM are associated with an impaired insulin signal pathway. These metabolic factors could increase the prevalence of AD in diabetic patients via the promotion of A β pathology.
    Type of Medium: Online Resource
    ISSN: 2314-6745 , 2314-6753
    URL: Article
    DOI: 10.1155/2020/4981814
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2020
    detail.hit.zdb_id: 2711897-6
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  • 4
    Online Resource
    Online Resource
    Molecular Characterization and Clinical Characteristics of m5C-Based RNA Methylation in Spinal Cord Injury: Validated by qPCR
    Hindawi Limited ; 2022
    In:  International Journal of Genomics Vol. 2022 ( 2022-12-20), p. 1-26
    Details
    In: International Journal of Genomics, Hindawi Limited, Vol. 2022 ( 2022-12-20), p. 1-26
    Abstract: Aberrant patterns of 5-methylcytosine (m5C)-based ribonucleic acid (RNA) methylation have critical roles in various human diseases, but their importance in spinal cord injury (SCI) is largely unknown. We explore the expression patterns and potential roles of m5C-based regulators of RNA modification after SCI. We analyzed 16 m5C-based regulators of RNA modification in tissues with SCI and normal rats from the Gene Expression Omnibus database. We constructed a “gene signature” of m5C-based regulators of RNA modification to predict the prognosis of SCI using least absolute shrinkage and selection operator regression and random-forest strategy. We found that the m5C-related genes, deoxyribonucleic acid (DNA) methyltransferase1 (Dnmt1), methyl-CpG binding domain protein 2 (Mbd2), ubiquitin-like with PHD and ring finger domains 1 (Uhrf1), uracil-N-glycosylase (Ung), and zinc finger and BTB(brica-brac, tramtrack, and broad) domain containing 38 (Zbtb38) had high expression, and zinc finger and BTB domain containing 4 (Zbtb4) had low expression in SCI. Analysis of the correlation between the gene sets of m5C-based regulators of RNA modification and immune-cell infiltration and immune response revealed Dnmt1, DNA methyltransferases 3A (Dnmt3a), Mbd2, and Ung to be positive regulators of the immune microenvironment, and Zbtb4 may negatively regulate the immune environment. Then, two molecular subtypes were identified based on 16 m5C-regulated genes. Functional-enrichment analysis of differentially expressed genes between different patterns of m5C-based modification was undertaken. Through the creation of a protein–protein interaction network, we screened 11 hub genes. We demonstrated their importance between SCI group and sham group using real-time reverse transcription-quantitative polymerase chain reaction in rat model. Expression of hub genes did not correlate with mitophagy but was positively correlated with endoplasmic reticulum stress (ERS), which suggested that there may be differences in ERS between different patterns of m5C-based modification. This present study explored and discovered the close link between m5C regulators-related genes and SCI. We also hope our findings may contribute to further mechanistic and therapeutic research on the role of key m5C regulators after SCI.
    Type of Medium: Online Resource
    ISSN: 2314-4378 , 2314-436X
    URL: Article
    DOI: 10.1155/2022/5433860
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2711883-6
    SSG: 12
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  • 5
    Online Resource
    Online Resource
    Stability Analysis of Support Anchor Bolt in the Process of Surrounding Rock Fracture Evolution
    Hindawi Limited ; 2023
    In:  Geofluids Vol. 2023 ( 2023-7-6), p. 1-14
    Details
    In: Geofluids, Hindawi Limited, Vol. 2023 ( 2023-7-6), p. 1-14
    Abstract: Various diseases and failures inevitably appear on expressway roadways in water-rich strata under the long-term erosion of water. It is very difficult to support the surrounding rock of a water-rich roadway because water will corrode the anchorage bond and weaken the surrounding rock mass. In the process of supporting, damage and fracture of anchor bolt often appear in water-rich roadway. In order to study the stability analysis of a support anchor bolt in the process of surrounding rock fracture evolution and the relationship between the prestressed value and the length of the anchor bolt, this paper studied the fracture evolution law of surrounding rock and the progressive debonding law of the bolt are studied by RFPA3D numerical simulation and used MATLAB software to calculate and draw several graphs to reveal the mechanism by analytical method. The following main conclusions were drawn: (1) the change and attenuation of the surrounding rock stress have a certain influence on the stability of the supporting bolt. The existence of confining pressure (horizontal stress) has a significant impact on the ultimate pullout force of anchor bolts. (2) With the gradual destruction of the surrounding rock, the shear stress, horizontal stress, and vertical stress in the surrounding rock are gradually reduced to zero, and the change speed of the surrounding rock is fast at the shallow surface and slow at the deep. (3) The interface shear stress tends to a low stable value after debonding, which means the value of friction resistance is relatively stable in different positions. (4) The frictional resistance after interface debonding is an important condition to maintain the balance of higher anchorage force. If there is no friction resistance, when the axial force of the anchor bolt reaches the initial critical value, the interface debunking process will develop catastrophically and cannot be stabilized until complete failure, even if the axial force no longer increases.
    Type of Medium: Online Resource
    ISSN: 1468-8123 , 1468-8115
    URL: Article
    DOI: 10.1155/2023/4805857
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2023
    detail.hit.zdb_id: 2045012-6
    SSG: 13
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