In:
International Journal of Vascular Medicine, Hindawi Limited, Vol. 2012 ( 2012), p. 1-6
Abstract:
Background . Recent data suggest that the renin-angiotensin system may be involved in triglyceride (TG) metabolism. We explored the effect of the common A1166C and C573T polymorphisms of the angiotensin II type 1 receptor (AT1R) gene on postprandial lipemia. Methods . Eighty-two subjects measured daytime capillary TG, and postprandial lipemia was estimated as incremental area under the TG curve. The C573T and A1166C polymorphisms of the AT1R gene were determined. Results . Postprandial lipemia was significantly higher in homozygous carriers of the 1166-C allele ( 9.39 ± 8.36 mM * h/L) compared to homozygous carriers of the 1166-A allele ( 2.02 ± 6.20 mM * h/L) ( P 〈 0.05 ). Postprandial lipemia was similar for the different C573T polymorphisms. Conclusion . The 1166-C allele of the AT1R gene seems to be associated with increased postprandial lipemia. These data confirm the earlier described relationships between the renin-angiotensin axis and triglyceride metabolism.
Type of Medium:
Online Resource
ISSN:
2090-2824
,
2090-2832
Language:
English
Publisher:
Hindawi Limited
Publication Date:
2012
detail.hit.zdb_id:
2573977-3
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