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  • 1
    Online Resource
    Online Resource
    Detection of Neoplastic Gastric Lesions Using Capsule Endoscopy: Pilot Study
    Hindawi Limited ; 2013
    In:  Gastroenterology Research and Practice Vol. 2013 ( 2013), p. 1-5
    Details
    In: Gastroenterology Research and Practice, Hindawi Limited, Vol. 2013 ( 2013), p. 1-5
    Abstract: Objectives . Capsule endoscopy is relatively noninvasive method and its use extends from the small bowel to the esophagus and colon. The aim of this study was to evaluate the feasibility and acceptability of capsule endoscopy for neoplastic gastric lesions. Methods . Capsule endoscopy (Pillcam ESO) was performed within 48 hours of esophagogastroduodenoscopy for eight patients who were diagnosed with gastric cancers, the size of which were less than 4 cm and who presented written consent. Patients changed position in a specified designed sequence every 30 seconds after capsule ingestion. Position change was repeated with ingestion of an effervescent agent. The rate of detection of intragastric lesions, observation of normal gastric anatomy and patient satisfaction between capsule endoscopy and esophagogastroduodenoscopy were compared. Results . Capsule endoscopy found four out of eight gastric lesions. The gastroesophageal junction was observed in seven of the eight cases, pyloric ring in five of the eight cases, and gastric angle in four of the eight cases. The patient satisfaction assessment questionnaire rated capsule endoscopy significantly higher than upper endoscopy in all categories. Conclusions . Capsule endoscopy was less effective than esophagogastroduodenoscopy and showed limited value in this feasibility study.
    Type of Medium: Online Resource
    ISSN: 1687-6121 , 1687-630X
    URL: Article
    DOI: 10.1155/2013/730261
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2013
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  • 2
    Online Resource
    Online Resource
    Balloon-Assisted Enteroscopy for Retrieval of Small Intestinal Foreign Bodies: A KASID Multicenter Study
    Hindawi Limited ; 2020
    In:  Gastroenterology Research and Practice Vol. 2020 ( 2020-05-19), p. 1-9
    Details
    In: Gastroenterology Research and Practice, Hindawi Limited, Vol. 2020 ( 2020-05-19), p. 1-9
    Abstract: Background and Aims . Balloon-assisted enteroscopy (BAE) can be used to retrieve small intestinal foreign bodies (FBs). Here, we aimed at exploring the clinical usefulness of BAE for the retrieval of small intestinal FBs. Methods . We retrospectively reviewed the medical records of 34 patients who underwent BAE to retrieve small intestinal FBs at 3 tertiary referral centers between April 2005 and June 2017. Results . The retained materials included capsule endoscopes (CEs; n = 18 [52.9%]), self-expandable metal stents (SEMSs; n = 5 [14.7%]), biliary drainage catheters ( n = 4 [11.8%]), gallstones ( n = 3 [8.8%]), an embolization coil (2.9%), a needle, an intragastric bariatric balloon, and a razor blade. FBs were located or stuck in the ileum ( n = 17 [50%]), jejunum ( n = 16 [47.1%]), and an undetermined small intestinal segment ( n = 1 ). Seventeen cases of FBs (50%; 7 CEs, 3 biliary drainage catheters, 3 SEMSs, 2 gallstones, 1 intragastric balloon, and 1 needle) were successfully retrieved enteroscopically. FBs of 4 asymptomatic patients (3 CEs and 1 razor blade) passed spontaneously. The remaining 13 patients underwent surgery for persistent or symptomatic FBs: 12 were successfully removed and 1 CE removal procedure failed due to severe peritoneal adhesions. The presence of symptoms was the only independent predictor of successful retrieval using BAE (odds ratio 13.40, 95% confidence interval 1.10–162.56, P = 0.042 ). BAE-related complications such as bowel perforation and acute pancreatitis occurred in 2 patients (5.9%). Conclusions . BAE can be the first option for FB removal in the small intestine. The presence of symptoms was associated with successful enteroscopic retrieval.
    Type of Medium: Online Resource
    ISSN: 1687-6121 , 1687-630X
    URL: Article
    DOI: 10.1155/2020/3814267
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2020
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  • 3
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    Online Resource
    A Disease Modification Effect of APOE E 4 on the Association between Urinary Albumin Excretion and Cognition in Korean Adults
    Hindawi Limited ; 2014
    In:  Disease Markers Vol. 2014 ( 2014), p. 1-7
    Details
    In: Disease Markers, Hindawi Limited, Vol. 2014 ( 2014), p. 1-7
    Abstract: Background . No previous study examined a disease modifying effect of APOE E 4 status on the association between the urinary albumin-to-creatinine ratio (UACR) and cognition. This study aimed to investigate whether APOE E 4 modified the association in Korean adults. Methods . We performed a cross-sectional study in adults aged 45 to 74 who were living in Namwon City, Republic of Korea. Cognitive function was measured with the Korean version of modified Mini-Mental State Examination (K-mMMSE) and cognitive impairment was defined as scores falling below the 25th percentile of the K-mMMSE according to age, sex, and educational attainments. Results . A total of 10,190 participants (4006 men and 6184 women) were analyzed in the present study. Of these, 1698 subjects (16.7%) were APOE E 4 carriers. The UACR values were negatively associated with the K-mMMSE scores, even after adjusting for potential confounders including age, sex, education, and vascular risk factors. APOE E 4 modified the association significantly, resulting in a steeper decline of cognitive function with the increase in UACR in E 4 carriers ( P for interaction = 0.021). Conclusion . Higher UACR values were significantly associated with cognitive dysfunction in the general Korean population, with cognition in APOE E 4 carriers being more severely affected by increased UACR.
    Type of Medium: Online Resource
    ISSN: 0278-0240 , 1875-8630
    URL: Article
    DOI: 10.1155/2014/724281
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2014
    detail.hit.zdb_id: 2033253-1
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  • 4
    Online Resource
    Online Resource
    Cover Image, Volume 41, Issue 8
    Hindawi Limited ; 2017
    In:  International Journal of Energy Research Vol. 41, No. 8 ( 2017-06-25), p. i-i
    Details
    In: International Journal of Energy Research, Hindawi Limited, Vol. 41, No. 8 ( 2017-06-25), p. i-i
    Type of Medium: Online Resource
    ISSN: 0363-907X
    URL: Issue
    URL: Article
    DOI: 10.1002/er.v41.8
    DOI: 10.1002/er.3789
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2017
    detail.hit.zdb_id: 1480879-1
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  • 5
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    Online Resource
    Improved electrochemical performance of a cyclic ultracapacitor using slurry electrodes under various flow conditions : Cyclic ultracapacitor for energy storage system
    Hindawi Limited ; 2017
    In:  International Journal of Energy Research Vol. 41, No. 8 ( 2017-06-25), p. 1202-1210
    Details
    In: International Journal of Energy Research, Hindawi Limited, Vol. 41, No. 8 ( 2017-06-25), p. 1202-1210
    Type of Medium: Online Resource
    ISSN: 0363-907X
    URL: Issue
    URL: Article
    DOI: 10.1002/er.v41.8
    DOI: 10.1002/er.3704
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2017
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  • 6
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    Online Resource
    Antibiotic-Related Adverse Drug Reactions at a Tertiary Care Hospital in South Korea
    Hindawi Limited ; 2017
    In:  BioMed Research International Vol. 2017 ( 2017), p. 1-7
    Details
    In: BioMed Research International, Hindawi Limited, Vol. 2017 ( 2017), p. 1-7
    Abstract: Background . Adverse drug reactions (ADRs) are any unwanted/uncomfortable effects from medication resulting in physical, mental, and functional injuries. Antibiotics account for up to 40.9% of ADRs and are associated with several serious outcomes. However, few reports on ADRs have evaluated only antimicrobial agents. In this study, we investigated antibiotic-related ADRs at a tertiary care hospital in South Korea. Methods . This is a retrospective cohort study that evaluated ADRs to antibiotics that were reported at a 2400-bed tertiary care hospital in 2015. ADRs reported by physicians, pharmacists, and nurses were reviewed. Clinical information reported ADRs, type of antibiotic, causality assessment, and complications were evaluated. Results . 1,277 (62.8%) patients were considered antibiotic-related ADRs based on the World Health Organization-Uppsala Monitoring Center criteria (certain, 2.2%; probable, 35.7%; and possible, 62.1%). Totally, 44 (3.4%) patients experienced serious ADRs. Penicillin and quinolones were the most common drugs reported to induce ADRs (both 16.0%), followed by third-generation cephalosporins (14.9%). The most frequently experienced side effects were skin manifestations (45.1%) followed by gastrointestinal disorders (32.6%). Conclusion . Penicillin and quinolones are the most common causative antibiotics for ADRs and skin manifestations were the most frequently experienced symptom.
    Type of Medium: Online Resource
    ISSN: 2314-6133 , 2314-6141
    URL: Article
    DOI: 10.1155/2017/4304973
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2017
    detail.hit.zdb_id: 2698540-8
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  • 7
    Online Resource
    Online Resource
    Protective Effect of Decursin Extracted from Angelica gigas in Male Infertility via Nrf2/HO-1 Signaling Pathway
    Hindawi Limited ; 2016
    In:  Oxidative Medicine and Cellular Longevity Vol. 2016 ( 2016), p. 1-9
    Details
    In: Oxidative Medicine and Cellular Longevity, Hindawi Limited, Vol. 2016 ( 2016), p. 1-9
    Abstract: Higher testicular temperature results in altered spermatogenesis due to heat-related oxidative stress. We examined the effects of decursin extracted from Angelica gigas Nakai on antioxidant activity in vitro and in a cryptorchidism-induced infertility rat model. TM3 Leydig cell viability was measured based on oxidative stress according to treatment. Either distilled water or AG 400 mg/kg of A. gigas extract was administered orally for 4 weeks after unilateral cryptorchidism was induced. After 1, 2, and 4 weeks, six rats from the control group and six rats from treatment group were sacrificed. Testicular weight, semen quality, antioxidant activities, nuclear factor erythroid 2-related factor 2 (Nrf2) protein, and mRNA expression of Nrf2-regulated genes were analyzed. Treatment with A. gigas extract (1) protected TM3 cells against oxidative stress in a dose-dependent manner, (2) improved the mean weight of the cryptorchid testis, (3) maintained sperm counts, motility, and spermatogenic cell density, (4) decreased levels of 8-hydroxy-2-deoxyguanosine (8-OHdG) and increased levels of superoxide dismutase (SOD), (5) significantly increased Nrf2 and heme oxygenase-1 (HO-1), and (6) significantly decreased apoptosis. This study suggests that decursin extracted from A. gigas is a supplemental agent that can reduce oxidative stress by Nrf2-mediated upregulation of HO-1 in rat experimentally induced unilateral cryptorchidism and may improve cryptorchidism-induced infertility.
    Type of Medium: Online Resource
    ISSN: 1942-0900 , 1942-0994
    URL: Article
    DOI: 10.1155/2016/5901098
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2016
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  • 8
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    Online Resource
    Efficient Promotion of Autophagy and Angiogenesis Using Mesenchymal Stem Cell Therapy Enhanced by the Low-Energy Shock Waves in the Treatment of Erectile Dysfunction
    Hindawi Limited ; 2018
    In:  Stem Cells International Vol. 2018 ( 2018-08-29), p. 1-14
    Details
    In: Stem Cells International, Hindawi Limited, Vol. 2018 ( 2018-08-29), p. 1-14
    Abstract: Background . Mesenchymal stem cell therapy (MSCT) and defocused low-energy shock wave therapy (ESWT) has been shown to ameliorate erectile dysfunction (ED). However, the interactions and effects of action between MSCT and ESWT remain poorly understood. In this study, we investigated the mechanisms of combination therapy with MSCT and ESWT in a rat model of diabetic ED. Materials and Methods . Eight-week-old male Sprague-Dawley rats were randomly divided into 2 parts. Diabetic rats induced by streptozotocin (65 mg/kg) were randomly divided into 4 groups: (1) DM control group, (2) DM + ESWT group, (3) DM + MSCT group, and (4) DM + ESWT + MSCT group. The sham group was a normal control group (without streptozotocin). MSCT and (or) ESWT were, respectively, administered to each group according to the proposal for 8 weeks. Immediately after recording of intracavernous pressure (ICP), the penis was then harvested for histologic analysis, ELISA, and Western blotting. Results . The ratio of ICP/MAP was significantly higher in the DM + ESWT + MSCT group than in ESWT or MSCT treated group ( P 〈 0.05 ). Also, the treatment stimulated angiogenesis and vasodilatation in the corpus cavernosum ( P 〈 0.05 ). ESWT increased the quantity of MSCs in the corpus cavernosum and also induced MSCs to express more VEGF in vitro and vivo ( P 〈 0.05 ) which activated the PI3K/AKT/mTOR and NO/cGMP signaling pathways in the corpus cavernosum. The combination approach stimulated autophagy and decreased apoptosis in the corpus cavernosum. NGF and BDNF expressions were higher in the DM + ESWT + MSCT group than in the DM control group ( P 〈 0.01 ). Furthermore, the treatment promoted the MSC recruitment by inducing penile tissues to express more PECAM and SDF-1. Conclusions . Combination of LI-ESWT and MSCT can get a better result than a single treatment by expressing more VEGF which can take part in autophagy by triggering the PI3K/AKT/mTOR signaling pathway. This cooperative therapy would provide a new research direction in ED treatment for the future.
    Type of Medium: Online Resource
    ISSN: 1687-966X , 1687-9678
    URL: Article
    DOI: 10.1155/2018/1302672
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2018
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  • 9
    Online Resource
    Online Resource
    Antioxidant and Antifibrotic Effect of a Herbal Formulation In Vitro and in the Experimental Andropause via Nrf2/HO-1 Signaling Pathway
    Hindawi Limited ; 2017
    In:  Oxidative Medicine and Cellular Longevity Vol. 2017 ( 2017), p. 1-10
    Details
    In: Oxidative Medicine and Cellular Longevity, Hindawi Limited, Vol. 2017 ( 2017), p. 1-10
    Abstract: The Korean herbal formulation Ojayeonjonghwan is used for improving late-onset hypogonadism (LOH) symptoms such as erectile dysfunction (ED). A previous research suggested that a modified Ojayeonjonghwan (KH-204) could be used as an alternative to the treatment for ED. The pharmacological effects were examined in different conditions, including in vitro and in vivo. We measured the survival rate of TM3 Leydig cells under the oxidative stress condition. The s.c. injection of leuprorelin was used to induce androgen deprivation. We measured serum testosterone levels, oxidative stress, and apoptosis. The results of the treatment by KH-204 (1) preserved TM3 cells from oxidative stress by improving the expression of nuclear factor erythroid 2-related factor 2 (Nrf2)/heme oxygenase-1 (HO-1); (2) lowered the expression of transforming growth factor-beta (TGF- β ) 1/SMAD; (3) increased the average of serum testosterone in androgen-deprived male rats; (4) kept the activation of spermatogenesis; (5) upgraded the contents of 8-hydroxy-20-deoxyguanosine (8-OHdG) and degraded the contents of superoxide dismutase (SOD); and (6) reduced apoptosis. We studied that KH-204 improved testicular dysfunction in LOH. It is likely, at least in part, to degrade oxidative stress through the Nrf2/HO-1 pathway. These findings may offer credible evidences for the use of new alternative therapies to treat LOH.
    Type of Medium: Online Resource
    ISSN: 1942-0900 , 1942-0994
    URL: Article
    DOI: 10.1155/2017/6024839
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2017
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  • 10
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    Online Resource
    Endoscopic Ultrasound-Guided Drainage without Fluoroscopic Guidance for Extraluminal Complicated Cysts
    Hindawi Limited ; 2016
    In:  Gastroenterology Research and Practice Vol. 2016 ( 2016), p. 1-8
    Details
    In: Gastroenterology Research and Practice, Hindawi Limited, Vol. 2016 ( 2016), p. 1-8
    Abstract: Background . Endoscopic ultrasound- (EUS-) guided drainage is generally performed under fluoroscopic guidance. However, improvements in endoscopic and EUS techniques and experience have led to questions regarding the usefulness of fluoroscopy. This study aimed to retrospectively evaluate the safety and efficacy of EUS-guided drainage of extraluminal complicated cysts without fluoroscopic guidance. Methods . Patients who had undergone nonfluoroscopic EUS-guided drainage of extraluminal complicated cysts were enrolled. Drainage was performed via a transgastric, transduodenal, or transrectal approach. Single or double 7 Fr double pigtail stents were inserted. Results . Seventeen procedures were performed in 15 patients in peripancreatic fluid collections ( n = 13 ) and pelvic abscesses ( n = 4 ). The median lesion size was 7.1 cm (range: 2.8–13.0 cm), and the mean time spent per procedure was 26.2 ± 9.8 minutes (range: 16–50 minutes). Endoscopic drainage was successful in 16 of 17 (94.1%) procedures. There were no complications. All patients experienced symptomatic improvement and revealed partial to complete resolution according to follow-up computed tomography findings. Two patients developed recurrent cysts that were drained during repeat procedures, with eventual complete resolution. Conclusion . EUS-guided drainage without fluoroscopic guidance is a technically feasible, safe, and effective procedure for the treatment of extraluminal complicated cysts.
    Type of Medium: Online Resource
    ISSN: 1687-6121 , 1687-630X
    URL: Article
    DOI: 10.1155/2016/1249064
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2016
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