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  • Hindawi Limited  (104)
  • 1
    Online Resource
    Online Resource
    Intravitreal Bevacizumab Injection Attenuates Diabetic Retinopathy in Adult Rats with Experimentally Induced Diabetes in the Early Stage
    Hindawi Limited ; 2018
    In:  Journal of Diabetes Research Vol. 2018 ( 2018-05-09), p. 1-18
    Details
    In: Journal of Diabetes Research, Hindawi Limited, Vol. 2018 ( 2018-05-09), p. 1-18
    Abstract: Diabetic retinopathy is the leading cause of blindness, yet its treatment is very limited. Anti-VEGF drug has been widely applied in ocular disease, but its effects on diabetic retinopathy and the underlying mechanism have remained to be fully explored. To elucidate the role of anti-VEGF treatment, we sought to determine the effects of bevacizumab on diabetic neurovascular changes extending from the 3rd to 9th week with induced diabetes in adult rats. The retinal neurovascular changes included increased expression of VEGF, nNOS, iNOS, eNOS, and NO in the course of diabetes progression. In diabetic rats given bevacizumab injection, the ganglion cell loss and alterations of retinal thickness were ameliorated. In this connection, the immunofluorescence labeling of the above biomarkers was noticeably decreased. Along with this, Western blotting confirmed that bevacizumab treatment was associated with a decrease of VEGF, Flk-1, and cAMP response element binding and protein kinase C protein expression. The present results suggest that bevacizumab treatment in the early stage of the retinopathy may ameliorate the lesions of retinopathy, in which VEGF/Flk-1 signaling has been shown here to play an important role.
    Type of Medium: Online Resource
    ISSN: 2314-6745 , 2314-6753
    URL: Article
    DOI: 10.1155/2018/9216791
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2018
    detail.hit.zdb_id: 2711897-6
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  • 2
    Online Resource
    Online Resource
    An Exploratory Study on a Chest-Worn Computer for Evaluation of Diet, Physical Activity and Lifestyle
    Hindawi Limited ; 2015
    In:  Journal of Healthcare Engineering Vol. 6, No. 1 ( 2015-03), p. 1-22
    Details
    In: Journal of Healthcare Engineering, Hindawi Limited, Vol. 6, No. 1 ( 2015-03), p. 1-22
    Type of Medium: Online Resource
    ISSN: 2040-2295
    URL: Article
    DOI: 10.1260/2040-2295.6.1.1
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2015
    detail.hit.zdb_id: 2545054-2
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  • 3
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    Online Resource
    BA6 Induces Apoptosis via Stimulation of Reactive Oxygen Species and Inhibition of Oxidative Phosphorylation in Human Lung Cancer Cells
    Hindawi Limited ; 2019
    In:  Oxidative Medicine and Cellular Longevity Vol. 2019 ( 2019-05-07), p. 1-21
    Details
    In: Oxidative Medicine and Cellular Longevity, Hindawi Limited, Vol. 2019 ( 2019-05-07), p. 1-21
    Abstract: Lung cancer is the leading cause of cancer deaths in the world, with a five-year survival rate of less than 30%. Clinically effective chemotherapeutic treatments at the initial stage may eventually face the dilemma of no drug being effective due to drug resistance; therefore, finding new effective drugs for lung cancer treatment is a necessary and important issue. Compounds capable of further increasing the oxidative stress of cancer cells are considered to have anticancer potential because they possessed the ability to induce apoptosis. This study mainly investigated the effects of BA6 (heteronemin), the marine sponge sesterterpene, on lung cancer cell apoptosis, via modulation of mitochondrial reactive oxygen species (mtROS) and oxidative phosphorylation (OXPHOS). BA6 has cellular cytotoxic activities against a variety of cancer cell lines, but it has no effect on nontumor cells. The BA6-treated lung cancer cells show a significant increase in both cellular ROS and mtROS, which in turn caused the loss of mitochondrial membrane potential (MMP). The increase of oxidative stress in lung cancer cells treated with BA6 was accompanied by a decrease in the expression of antioxidant enzymes Cu/Zn SOD, MnSOD, and catalase. In addition, OXPHOS performed in the mitochondria and glycolysis in the cytoplasm were inhibited, which subsequently reduced downstream ATP production. Pretreatment with mitochondria-targeted antioxidant MitoTEMPO reduced BA6-induced apoptosis through the mitochondria-dependent apoptotic pathway, which was accompanied by increased cell viability, decreased mtROS, enhanced MMP, and suppressed expression of cleaved caspase-3 and caspase-9 proteins. In conclusion, the results of this study clarify the mechanism of BA6-induced apoptosis in lung cancer cells via the mitochondrial apoptotic pathway, suggesting that it is a potentially innovative alternative to the treatment of human lung cancer.
    Type of Medium: Online Resource
    ISSN: 1942-0900 , 1942-0994
    URL: Article
    DOI: 10.1155/2019/6342104
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2019
    detail.hit.zdb_id: 2455981-7
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  • 4
    Online Resource
    Online Resource
    Simultaneous Determination of Salicylic Acid, Jasmonic Acid, Methyl Salicylate, and Methyl Jasmonate from Ulmus pumila Leaves by GC-MS
    Hindawi Limited ; 2015
    In:  International Journal of Analytical Chemistry Vol. 2015 ( 2015), p. 1-7
    Details
    In: International Journal of Analytical Chemistry, Hindawi Limited, Vol. 2015 ( 2015), p. 1-7
    Abstract: Salicylic acid, jasmonic acid, methyl salicylate, and methyl jasmonate are important phytohormones and defensive signaling compounds, so it is of great importance to determine their levels rapidly and accurately. The study uses Ulmus pumila leaves infected by Tetraneura akinire Sasaki at different stages as materials; after extraction with 80% methanol and ethyl acetate and purification with primary secondary amine (PSA) and graphitized carbon blacks (GCB), the contents of signal compounds salicylic acid, jasmonic acid, methyl salicylate, and methyl jasmonate were determined by GC-MS. The results showed that the level of salicylic acid, jasmonic acid, methyl salicylate, and methyl jasmonate increased remarkably in U. pumila once infected by T. akinire Sasaki , but the maximums of these four compounds occurred at different times. Salicylic acid level reached the highest at the early stage, and jasmonic acid level went to the maximum in the middle stage; by contrast, change of content of methyl salicylate and methyl jasmonate was the quite opposite.
    Type of Medium: Online Resource
    ISSN: 1687-8760 , 1687-8779
    URL: Article
    DOI: 10.1155/2015/698630
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2015
    detail.hit.zdb_id: 2494714-3
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  • 5
    Online Resource
    Online Resource
    MicroRNA-181a-5p Promotes Osteosarcoma Progression via PTEN/AKT Pathway
    Hindawi Limited ; 2022
    In:  Analytical Cellular Pathology Vol. 2022 ( 2022-3-8), p. 1-13
    Details
    In: Analytical Cellular Pathology, Hindawi Limited, Vol. 2022 ( 2022-3-8), p. 1-13
    Abstract: Osteosarcoma is the most common primary malignant bone tumor in children and adolescents with poor prognosis. MicroRNA-181a-5p (miR-181a-5p) is involved in the progression of various tumors; however, its role and underlying mechanism in osteosarcoma remains unclear. In this study, we found that miR-181a-5p was upregulated in human osteosarcoma cells and tissues. miR-181a-5p mimic significantly promoted, while miR-181a-5p inhibitor blocked the proliferation, colony formation, migration, invasion, and cell cycle progression of osteosarcoma cells. Mechanistically, miR-181a-5p bound to the 3 ′ -untranslational region of phosphatase and tensin homolog (PTEN) and reduced its protein expression, thereby activating protein kinase B (PKB/AKT) pathway. Either PTEN overexpression or AKT inhibition notably blocked the tumor-promoting effects of miR-181a-5p. Moreover, we observed that miR-181a-5p mimic further inhibited growth of human osteosarcoma cells in the presence of adriamycin or cisplatin. Overall, miR-181a-5p promotes osteosarcoma progression via PTEN/AKT pathway and it is a promising therapeutic target to treat osteosarcoma.
    Type of Medium: Online Resource
    ISSN: 2210-7185 , 2210-7177
    URL: Article
    DOI: 10.1155/2022/3421600
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2584078-2
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  • 6
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    Online Resource
    The Influence of Parents’ Background and Their Perception on the Progression of Myopia in Children
    Hindawi Limited ; 2022
    In:  International Journal of Clinical Practice Vol. 2022 ( 2022-11-24), p. 1-7
    Details
    In: International Journal of Clinical Practice, Hindawi Limited, Vol. 2022 ( 2022-11-24), p. 1-7
    Abstract: Purpose. To study the influence of parents’ educational backgrounds and understanding on the progress of myopia in their offspring. Methods. Spherical equivalent refraction (SE) of the children (aged 6–14) in China was assessed with cycloplegic autorefraction in a two-year longitudinal study. The parents’ background information and myopia-related cognition were collected by questionnaires. Results. The offspring of parents with lower education and more myopic SE had higher myopic progression (mean = –1.42 ± 1.06) than the children of other groups ( P 〈 0.05 ). The parents’ understanding of the proper outdoor activity time, sleep duration, reading distance, and indoor illumination for children was not significantly correlated with the progression of myopia in their offspring. The parent’s preference for eye care visit frequency had a significant correlation with the myopia development of their children (r = 0.076, P = 0.001 ∗ ). The mean SE progression was −0.84 ± 1.37 and −0.58 ± 1.29 in the children whose parents considered that extracurricular classes would negatively affect myopia development progression and the children whose parents believed it would not, respectively ( P = 0.026 ∗ ). Conclusions. Most parents misunderstand the influence of insufficient outdoor sports time and extracurricular classes, which require extra near-vision work. Besides, for parents with low educational background and more myopic SE, their offspring had higher myopia progression and may be the key group for myopia control. Finally, parents may obtain life advice and knowledge related to preventing myopia after their children become myopic. It may be of positive significance if this process could take place before myopia onset.
    Type of Medium: Online Resource
    ISSN: 1742-1241 , 1368-5031
    URL: Article
    DOI: 10.1155/2022/4123470
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2135320-7
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  • 7
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    Online Resource
    IOV Privacy Protection System Based on Double-Layered Chains
    Hindawi Limited ; 2019
    In:  Wireless Communications and Mobile Computing Vol. 2019 ( 2019-03-07), p. 1-11
    Details
    In: Wireless Communications and Mobile Computing, Hindawi Limited, Vol. 2019 ( 2019-03-07), p. 1-11
    Abstract: As the Internet of Vehicle (IOV) being widely applied throughout our daily life, how to secure data privacy of each vehicle is nowadays a hot topic. Taking an aim of solving this problem, a privacy protection system on double-layered chain basis is designed to eliminate the said security risk during vehicle data communication. At the same time, the nontampering nature of the block chain is used to realize reasonable arbitration in traffic accident disputes, vehicle insurance claims, and other states of affairs. Specifically, an IOV double-layered chain model is constructed to simulate a semicentralized system that is convenient for government to supervise; also, a RSA protocol based on zero-knowledge proof (ZKP) is designed to bring safety and zero-knowledge property to the system; finally, we give the application scenario of this IOV privacy protection system based on double-layered chain that it can be widely used in vehicle-sharing industry. The communication costs, respectively, under double-layered chain and single-layered chain frameworks, are compared to prove that the double-layered structure does save cost. Thus an IOV privacy scheme that is safer and more cost-efficient is given.
    Type of Medium: Online Resource
    ISSN: 1530-8669 , 1530-8677
    URL: Article
    DOI: 10.1155/2019/3013562
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2019
    detail.hit.zdb_id: 2045240-8
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  • 8
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    Online Resource
    Antimelanoma and Antityrosinase from Alpinia galangal Constituents
    Hindawi Limited ; 2013
    In:  The Scientific World Journal Vol. 2013 ( 2013), p. 1-5
    Details
    In: The Scientific World Journal, Hindawi Limited, Vol. 2013 ( 2013), p. 1-5
    Abstract: Two compounds, 1,7-bis(4-hydroxyphenyl)-1,4,6-heptatrien-3-one (BHPHTO) and bisdemethoxycurcumin (BDMC) they have been isolated from the rhizomes of Alpinia galangal , and the structures of both pure constituents were determined using spectroscopic analyses. The study examined the bioeffectivenesses of the two compounds on the human melanoma A2058 and showed that significantly inhibited the proliferation of melanoma cells in the cell viability assay. This research was also taken on the tests to B16-F10 cell line and showed minor inhibitory consequences of cellular tyrosinase activities and melanin contents. Our results revealed the anticancer effects of A. galangal compounds, and therefore, the target compounds could be potentially applied in the therapeutic application and the food industry.
    Type of Medium: Online Resource
    ISSN: 1537-744X
    URL: Article
    DOI: 10.1155/2013/186505
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2013
    detail.hit.zdb_id: 2075968-X
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  • 9
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    Online Resource
    Optimal Tracking Performance of MIMO Discrete-Time Systems with Network Parameters
    Hindawi Limited ; 2016
    In:  Discrete Dynamics in Nature and Society Vol. 2016 ( 2016), p. 1-7
    Details
    In: Discrete Dynamics in Nature and Society, Hindawi Limited, Vol. 2016 ( 2016), p. 1-7
    Abstract: The optimal regulation properties of multi-input and multioutput (MIMO) discrete-time networked control systems (NCSs), over additive white Gaussian noise (AWGN) fading channels, based on state space representation, are investigated. The average performance index is introduced. Moreover, the regulation performance is measured by the control energy and the error energy of the system, and fundamental limitations are obtained. Two kinds of network parameters, fading and the additive white Gaussian noise, are considered. The best attainable regulation performance limitations can be obtained by the limiting steady state solution of the corresponding algebraic Riccati equation (ARE). The simulation results are given to demonstrate the main results of the theoretical development.
    Type of Medium: Online Resource
    ISSN: 1026-0226 , 1607-887X
    URL: Article
    DOI: 10.1155/2016/6826130
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2016
    detail.hit.zdb_id: 2033014-5
    SSG: 11
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  • 10
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    Clinicopathological Characteristics, Treatment, and Prognosis of Rarely Primary Epididymal Adenocarcinoma: A Review and Update
    Hindawi Limited ; 2017
    In:  BioMed Research International Vol. 2017 ( 2017), p. 1-9
    Details
    In: BioMed Research International, Hindawi Limited, Vol. 2017 ( 2017), p. 1-9
    Abstract: Primary epididymal adenocarcinoma (PEA) is exceedingly rare. Only 22 cases had been published worldwide by 2008; nearly 80% of these cases were reported before 2007. In order to investigate the current clinical status of PEA, we search for relevant literatures with “epididymis and adenocarcinoma” and “epididymal and adenocarcinoma” as keywords published between January 1997 and November 2017 in PubMed. As a result, 17 cases are identified. We review these cases and summarize new and important perspectives about the clinicopathological characteristics, diagnosis, treatment, and prognosis of PEA in the present review.
    Type of Medium: Online Resource
    ISSN: 2314-6133 , 2314-6141
    URL: Article
    DOI: 10.1155/2017/4126740
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2017
    detail.hit.zdb_id: 2698540-8
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