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  • 1
    Online Resource
    Online Resource
    Proteomics Shows New Faces for the Old Penicillin Producer Penicillium chrysogenum
    Hindawi Limited ; 2012
    In:  Journal of Biomedicine and Biotechnology Vol. 2012 ( 2012), p. 1-15
    Details
    In: Journal of Biomedicine and Biotechnology, Hindawi Limited, Vol. 2012 ( 2012), p. 1-15
    Abstract: Fungi comprise a vast group of microorganisms including the Ascomycota (majority of all described fungi), the Basidiomycota (mushrooms or higher fungi), and the Zygomycota and Chytridiomycota (basal or lower fungi) that produce industrially interesting secondary metabolites, such as β-lactam antibiotics. These compounds are one of the most commonly prescribed drugs world-wide. Since Fleming's initial discovery of Penicillium notatum 80 years ago, the role of Penicillium as an antimicrobial source became patent. After the isolation of Penicillium chrysogenum NRRL 1951 six decades ago, classical mutagenesis and screening programs led to the development of industrial strains with increased productivity (at least three orders of magnitude). The new “omics” era has provided the key to understand the underlying mechanisms of the industrial strain improvement process. The review of different proteomics methods applied to P. chrysogenum has revealed that industrial modification of this microorganism was a consequence of a careful rebalancing of several metabolic pathways. In addition, the secretome analysis of P. chrysogenum has opened the door to new industrial applications for this versatile filamentous fungus.
    Type of Medium: Online Resource
    ISSN: 1110-7243 , 1110-7251
    URL: Article
    DOI: 10.1155/2012/105109
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2012
    detail.hit.zdb_id: 2698540-8
    detail.hit.zdb_id: 2512507-2
    SSG: 12
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  • 2
    Online Resource
    Online Resource
    Response to Infliximab in Crohn’s Disease: Genetic Analysis Supporting Expression Profile
    Hindawi Limited ; 2015
    In:  Mediators of Inflammation Vol. 2015 ( 2015), p. 1-8
    Details
    In: Mediators of Inflammation, Hindawi Limited, Vol. 2015 ( 2015), p. 1-8
    Abstract: Substantial proportion of Crohn’s disease (CD) patients shows no response or a limited response to treatment with infliximab (IFX) and to identify biomarkers of response would be of great clinical and economic benefit. The expression profile of five genes ( S100A8-S100A9, G0S2, TNFAIP6 , and IL11 ) reportedly predicted response to IFX and we aimed at investigating their etiologic role through genetic association analysis. Patients with active CD (350) who received at least three induction doses of IFX were included and classified according to IFX response. A tagging strategy was used to select genetic polymorphisms that cover the variability present in the chromosomal regions encoding the identified genes with altered expression. Following genotyping, differences between responders and nonresponders to IFX were observed in haplotypes of the studied regions: S100A8 - S100A9 (rs11205276 * G/rs3014866 * C/rs724781 * C/rs3006488 * A; P = 0.05 ); G0S2 (rs4844486 * A/rs1473683 * T; P = 0.15 ); TNFAIP6 (rs11677200 * C/rs2342910 * A/rs3755480 * G/rs10432475 * A; P = 0.10 ); and IL11 (rs1126760 * C/rs1042506 * G; P = 0.07 ). These differences were amplified in patients with colonic and ileocolonic location for all but the TNFAIP6 haplotype, which evidenced significant difference in ileal CD patients. Our results support the role of the reported expression signature as predictive of anti-TNF outcome in CD patients and suggest an etiological role of those top-five genes in the IFX response pathway.
    Type of Medium: Online Resource
    ISSN: 0962-9351 , 1466-1861
    URL: Article
    DOI: 10.1155/2015/318207
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2015
    detail.hit.zdb_id: 2008065-7
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  • 3
    Online Resource
    Online Resource
    Aerogel-Based TiO 2 Stable Inks for Direct Inkjet Printing of Nanostructured Layers
    Hindawi Limited ; 2020
    In:  Advances in Materials Science and Engineering Vol. 2020 ( 2020-07-30), p. 1-9
    Details
    In: Advances in Materials Science and Engineering, Hindawi Limited, Vol. 2020 ( 2020-07-30), p. 1-9
    Abstract: Inkjet printing presents a high potential for cost reduction of electronic devices manufacturing due to the capacity to deposit materials with high precision, less material waste, and large-scale production through the roll-to-roll printing processes. In this work, a nanostructured TiO 2 ink was developed using TiO 2 aerogel and an alkaline aqueous solution, which resulted in a very stable suspension. A high-intensity ultrasonic mixer was used to fragment and disperse TiO 2 aerogels producing suspensions with particles smaller than 200 nm, which are suitable for the inkjet printing process. For the development of the ink, the viscosity and surface tension were adjusted by using glycerol and a surfactant (Triton X-100). The influence of those components on the properties of the ink was evaluated for different concentrations. After formulation of the inks, the printing parameters were adjusted to optimize the process. Films with high surface area and less than 100 nm grain size were successfully produced. Electrical measurements revealed a resistive-like behavior with the sheet resistance increasing with number of printed layers.
    Type of Medium: Online Resource
    ISSN: 1687-8434 , 1687-8442
    URL: Article
    DOI: 10.1155/2020/4273097
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2020
    detail.hit.zdb_id: 2501025-6
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  • 4
    Online Resource
    Online Resource
    A Novel Intraurethral Device Diagnostic Index to Classify Bladder Outlet Obstruction in Men with Lower Urinary Tract Symptoms
    Hindawi Limited ; 2009
    In:  Advances in Urology Vol. 2009 ( 2009), p. 1-6
    Details
    In: Advances in Urology, Hindawi Limited, Vol. 2009 ( 2009), p. 1-6
    Abstract: Objectives . Using a urethral device at the fossa navicularis, bladder pressure during voiding can be estimated by a minimal invasive technique. This study purposes a new diagnostic index for patients with lower urinary tract symptoms (LUTSs). Methods . Fifty one patients presenting with LUTSs were submitted to a conventional urodynamic and a minimal invasive study. The results obtained through the urethral device and invasive classic urodynamics were compared. The existing bladder outlet obstruction index (BOOI) equation that classifies men with LUTSs was modified to allow minimal invasive measurement of isovolumetric bladder pressure in place of detrusor pressure at maximum urine flow. Accuracy of the new equation for classifying obstruction was then tested in this group of men. Results . The modified equation identified men with obstruction with a positive predictive value of 68% and a negative predictive value of 70%, with an overall accuracy of 70%. Conclusions . The proposed equation can accurately classify over 70% of men without resorting to invasive pressure flow studies. We must now evaluate the usefulness of this classification for the surgical treatment of men with LUTSs.
    Type of Medium: Online Resource
    ISSN: 1687-6369 , 1687-6377
    URL: Article
    DOI: 10.1155/2009/406012
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2009
    detail.hit.zdb_id: 2397564-7
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  • 5
    Online Resource
    Online Resource
    Bioconversion of Sugarcane Vinasse into High-Added Value Products and Energy
    Hindawi Limited ; 2017
    In:  BioMed Research International Vol. 2017 ( 2017), p. 1-11
    Details
    In: BioMed Research International, Hindawi Limited, Vol. 2017 ( 2017), p. 1-11
    Abstract: Vinasse, a residue from bioethanol production containing high organic matter concentration, was used as substrate in submerged fermentation of Pseudomonas aeruginosa PA1 for biosurfactant production. About 2.7 g/L of rhamnolipids was obtained, with surface tension of 29.2 mN/m and critical micelle concentration of 80.3 mg/L. After separation of rhamnolipid and biomass, residual fermentation media were submitted to anaerobic biodegradation in mesophilic conditions. The residual medium derived from fermentation with vinasse diluted to 1 : 1, without addition of nitrogen, C : N 21, and for 168 h, led to 63.2% chemical oxygen demand (COD) removal and 97.6 mL CH 4 /g C O D r e m o v e d . Compared to results obtained with fresh vinasse (73.7% COD removal and 112.4 mL CH 4 /g C O D r e m o v e d ), it could be concluded that both processes can be integrated in order to add value to the residue and obtain energy, reducing production costs and at the same time environmental impacts related to vinasse disposal.
    Type of Medium: Online Resource
    ISSN: 2314-6133 , 2314-6141
    URL: Article
    DOI: 10.1155/2017/8986165
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2017
    detail.hit.zdb_id: 2698540-8
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