In:
BioMed Research International, Hindawi Limited, Vol. 2014 ( 2014), p. 1-6
Abstract:
Stroke variably activates interleukin- (IL-) 17 expression, reduces regulatory T cells, and induces oxidative stress, which may support neurodegeneration. Ischemic stroke patients were screened for depressive symptoms (Center for Epidemiological Studies Depression (CES-D)) and cognitive status (Mini Mental State Examination). Proinflammatory cytokines (IL-17, IL-23, and interferon- [IFN-] γ ), anti-inflammatory cytokine IL-10, and lipid hydroperoxide (LPH), a measure of oxidative stress, were assayed from fasting serum. Of 47 subjects (age 71.8 ± 14.4 years, 36% female), 19 had depressive symptoms (CES-D ≥ 16), which was associated with poorer cognitive status ( F 1,46 = 8.44 , P = 0.006 ). IL-17 concentrations did not differ between subjects with and without depressive symptoms ( F 1,46 = 8.44 , P = 0.572 ); however, IL-17 was associated with poorer cognitive status in subjects with depressive symptoms ( F 1,46 = 9.29 , P = 0.004 ). In those subjects with depressive symptoms, IL-17 was associated with higher LPH ( ρ = 0.518 , P = 0.023 ) and lower IL-10 ( ρ = - 0.484 , P = 0.036 ), but not in those without. In conclusion, poststroke depressive symptoms may be associated with cognitive vulnerability to IL-17 related pathways, involving an imbalance between proinflammatory and anti-inflammatory activity and increased oxidative stress.
Type of Medium:
Online Resource
ISSN:
2314-6133
,
2314-6141
Language:
English
Publisher:
Hindawi Limited
Publication Date:
2014
detail.hit.zdb_id:
2698540-8
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