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  • Hindawi Limited  (18)
  • 1
    Online Resource
    Online Resource
    Curcumin Antagonizes Glucose Fluctuation-Induced Renal Injury by Inhibiting Aerobic Glycolysis via the miR-489/LDHA Pathway
    Hindawi Limited ; 2021
    In:  Mediators of Inflammation Vol. 2021 ( 2021-8-18), p. 1-25
    Details
    In: Mediators of Inflammation, Hindawi Limited, Vol. 2021 ( 2021-8-18), p. 1-25
    Abstract: It has been considered that glucose fluctuation (GF) plays a role in renal injury and is related to diabetic nephropathy (DN) development. But the mechanism is still unclear. Aerobic glycolysis has become a topical issue in DN in recent years. There is an internal connection between GF, aerobic glycolysis, and DN. Curcumin (Cur) is a principal curcuminoid of turmeric and possesses specific protective properties in kidney functions. Cur also participates in the regulation of aerobic glycolysis switch. In this study, we first measured the levels of aerobic glycolysis and evaluated Cur’s inhibitory ability in a cell model of HEK-293 under the condition of oscillating high glucose. The results indicated that GF exacerbated inflammation injury, oxidative stress, and apoptosis in HEK-293 cell, while Cur alleviated this cytotoxicity induced by GF. We found that GF increased aerobic glycolysis in HEK-293 cells and Cur presented a dose-dependent weakening effect to this exacerbation. Next, we built a panel of 17 miRNAs and 8 lncRNAs that were previously reported to mediate the Warburg effect. Our RT-qPCR results indicated that GF reduced the miR-489 content in the HEK-293 cell model and Cur could prevent this downregulation. Then, we planned to explore the character of miR-489 in Cur-triggered attenuation of the Warburg effect under GF condition. Our findings presented that Cur prevented GF-triggered aerobic glycolysis by upregulating miR-489 in HEK-293 cells. Next, we choose the miR-489/LDHA axis for further investigation. We confirmed that Cur prevented GF-triggered aerobic glycolysis via the miR-489/LDHA axis in HEK-293 cells. In conclusion, this study presented that Cur prevented GF-triggered renal injury by restraining aerobic glycolysis via the miR-489/LDHA axis in the HEK-293 cell model.
    Type of Medium: Online Resource
    ISSN: 1466-1861 , 0962-9351
    URL: Article
    DOI: 10.1155/2021/6104529
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2021
    detail.hit.zdb_id: 2008065-7
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  • 2
    Online Resource
    Online Resource
    Hotspot Detection with Machine Learning Based on Pixel-Based Feature Extraction
    Hindawi Limited ; 2022
    In:  Scientific Programming Vol. 2022 ( 2022-8-23), p. 1-11
    Details
    In: Scientific Programming, Hindawi Limited, Vol. 2022 ( 2022-8-23), p. 1-11
    Abstract: The complexity of physical verification increases rapidly with fast shrinking technology nodes. Considering only design rule checking (DRC) constraints or lithography models cannot capture the side physical effects in the fabrication process well. Thus, it is desirable to consider a more general physical verification problem with various types of hotspots. In this paper, we apply machine learning which is based on pixel-based feature extraction to deal with the generalized hotspot detection problem. First, a two-dimensional discrete Fourier transformation-based pixel extraction method is proposed to alleviate the shifting effect and produce stable hotspot features. Then, a pattern-based layout scanning approach is developed to enhance the program efficiency while preserving good detection accuracy. Finally, we design two false alarm reduction strategies to effectively reduce the number of detected nonhotspots and further improve the accuracy of hotspot position. Experimental results based on the industrial benchmarks show that our algorithm outperforms three competitive works in terms of accuracy, false alarm rate, efficiency, and time.
    Type of Medium: Online Resource
    ISSN: 1875-919X , 1058-9244
    URL: Article
    DOI: 10.1155/2022/7803329
    RVK:
    SA 7860
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2070004-0
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  • 3
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    Numerical Approximation of the Space Fractional Cahn-Hilliard Equation
    Hindawi Limited ; 2019
    In:  Mathematical Problems in Engineering Vol. 2019 ( 2019-04-01), p. 1-10
    Details
    In: Mathematical Problems in Engineering, Hindawi Limited, Vol. 2019 ( 2019-04-01), p. 1-10
    Abstract: In this paper, a second-order accurate (in time) energy stable Fourier spectral scheme for the fractional-in-space Cahn-Hilliard (CH) equation is considered. The time is discretized by the implicit backward differentiation formula (BDF), along with a linear stabilized term which represents a second-order Douglas-Dupont-type regularization. The semidiscrete schemes are shown to be energy stable and to be mass conservative. Then we further use Fourier-spectral methods to discretize the space. Some numerical examples are included to testify the effectiveness of our proposed method. In addition, it shows that the fractional order controls the thickness and the lifetime of the interface, which is typically diffusive in integer order case.
    Type of Medium: Online Resource
    ISSN: 1024-123X , 1563-5147
    URL: Article
    DOI: 10.1155/2019/3163702
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2019
    detail.hit.zdb_id: 2014442-8
    SSG: 11
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  • 4
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    Online Resource
    Genetic characteristics, pathogenicity and transmission of H5N6 highly pathogenic avian influenza viruses in Southern China
    Hindawi Limited ; 2019
    In:  Transboundary and Emerging Diseases Vol. 66, No. 6 ( 2019-11), p. 2411-2425
    Details
    In: Transboundary and Emerging Diseases, Hindawi Limited, Vol. 66, No. 6 ( 2019-11), p. 2411-2425
    Type of Medium: Online Resource
    ISSN: 1865-1674 , 1865-1682
    URL: Issue
    URL: Article
    DOI: 10.1111/tbed.v66.6
    DOI: 10.1111/tbed.13299
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2019
    detail.hit.zdb_id: 2414822-2
    SSG: 22
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  • 5
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    Online Resource
    Pyoderma gangrenosum secondary to caesarean section treated with negative pressure wound therapy and skin graft
    Hindawi Limited ; 2021
    In:  Dermatologic Therapy Vol. 34, No. 2 ( 2021-03)
    Details
    In: Dermatologic Therapy, Hindawi Limited, Vol. 34, No. 2 ( 2021-03)
    Type of Medium: Online Resource
    ISSN: 1396-0296 , 1529-8019
    URL: Issue
    URL: Article
    DOI: 10.1111/dth.v34.2
    DOI: 10.1111/dth.14858
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2021
    detail.hit.zdb_id: 2020064-X
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  • 6
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    Molecular cloning and structural characterization of PPARα gene from turbot ( Scophthalmus maximus ) and functional exploration of lipid metabolism in response to thermal stress
    Hindawi Limited ; 2022
    In:  Aquaculture Research Vol. 53, No. 7 ( 2022-05), p. 2608-2618
    Details
    In: Aquaculture Research, Hindawi Limited, Vol. 53, No. 7 ( 2022-05), p. 2608-2618
    Type of Medium: Online Resource
    ISSN: 1355-557X , 1365-2109
    URL: Issue
    URL: Article
    DOI: 10.1111/are.v53.7
    DOI: 10.1111/are.15778
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2207423-5
    detail.hit.zdb_id: 1227359-4
    detail.hit.zdb_id: 2019895-4
    SSG: 21,3
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  • 7
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    Online Resource
    Hydrochemical Characteristics and Evolution Mode of Cold Seeps in the Qiongdongnan Basin, South China Sea
    Hindawi Limited ; 2020
    In:  Geofluids Vol. 2020 ( 2020-01-07), p. 1-16
    Details
    In: Geofluids, Hindawi Limited, Vol. 2020 ( 2020-01-07), p. 1-16
    Abstract: Submarine cold seeps have recently attracted significant attention and are among the most effective indicators of gas hydrate in the oceans. In this study, remotely operated vehicle (ROV) observations, seismic profiles, core sediments, bottom seawater, and fluid vented from cold seeps in the deep-water Qiongdongnan Basin were used to investigate the origin and evolution of cold seeps and their relationships with gas hydrate. At stations A, B, and C, inactive cold seeps with dead clams, cold seep leakage with live clams, and active cold seeps with a rich mussel presence, respectively, were observed. The salinity and Na + and Cl - concentrations of the cold seeps were different from those of typical seawater owing to gas hydrate formation and decomposition and fluid originating from various depths. The main ion concentrations of the bottom seawater at stations B and C were higher than those at station A, indicating the substantial effects of low-salinity cold seep fluids from gas hydrate decomposition. The Na + -Cl - , K + -Cl - , Mg 2+ -Cl - , and Ca 2+ -Cl - diagrams and rare earth element distribution curves of the water samples were strongly affected by seawater. The concentrations of trace elements and their ratios to Cl - in the bottom seawater were high at the stations with cold seeps, suggesting the mixing of other fluids rich in those elements. Biochemical reactions may also have caused the chemical anomalies. Samples of HM-ROV-1 indicated a greater effect of upward cold seep fluids with higher B/Cl - , Sr/Cl - , and Ba/Cl - values. Moreover, the Re/Cl - value varied between fluid vents, possibly due to differences in Re precipitation strength. Differences in cold seep intensity are also believed to occur between areas. The cold seep fluxes changed from large to small before finally disappearing, showing a close connection with gas hydrate formation and decomposition, and influenced the local topography and ecosystems.
    Type of Medium: Online Resource
    ISSN: 1468-8115 , 1468-8123
    URL: Article
    DOI: 10.1155/2020/4578967
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2020
    detail.hit.zdb_id: 2045012-6
    SSG: 13
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  • 8
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    The Correlations of Disease Activity, Socioeconomic Status, Quality of Life, and Depression/Anxiety in Chinese Patients with Systemic Lupus Erythematosus
    Hindawi Limited ; 2013
    In:  Clinical and Developmental Immunology Vol. 2013 ( 2013), p. 1-6
    Details
    In: Clinical and Developmental Immunology, Hindawi Limited, Vol. 2013 ( 2013), p. 1-6
    Abstract: The prevalence of psychological problems is frequent in systemic lupus erythematosus (SLE) patients and appears to be increasing. The current study investigated the relationship among disease parameters, quality of life, and the psychological status in Chinese patients with SLE. A self-report survey design was administered to 170 SLE patients and 210 healthy individuals using the Self-Rating Anxiety Scale, the Self-Rating Depression Scale, and the Short Form 36 health survey (SF-36). Our results showed that 20.3% SLE patients had anxiety, and 32.9% had depression, which were significantly higher than the control group (7.1%, 14.3%, resp.). And there were significant correlations among socioeconomic status (SES), disease activity, and anxiety/depression in SLE patients. Meanwhile, SF-36 analysis results revealed that VT, PF, and RP scales were the most powerful predictors of anxiety of SLE patients, and SLEDAI, VT, PF, SF, and RE domains were significantly accounted for anxiety. In summary, there were significant relationships among disease parameters, quality of life, and anxiety/depression in Chinese SLE patients. Therefore, it is necessary to have psychiatric and psychological evaluations and formulate an integrated approach for managing mental health in Chinese lupus patients, especially those who have high disease activity, low SES, and poor quality of life.
    Type of Medium: Online Resource
    ISSN: 1740-2522 , 1740-2530
    URL: Article
    DOI: 10.1155/2013/270878
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2013
    detail.hit.zdb_id: 2817541-4
    detail.hit.zdb_id: 2119272-8
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  • 9
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    Online Resource
    Gas Hydrate Accumulation and Occurrence Associated with Cold Seep Systems in the Northern South China Sea: An Overview
    Hindawi Limited ; 2021
    In:  Geofluids Vol. 2021 ( 2021-10-05), p. 1-24
    Details
    In: Geofluids, Hindawi Limited, Vol. 2021 ( 2021-10-05), p. 1-24
    Abstract: Studying deep-water cold seep systems is of great significance to gas hydrate exploration due to their close relationship. Various cold seep systems and related gas hydrate accumulations have been discovered in the northern South China Sea in the past three decades. Based on high-resolution seismic data, subbottom profiles, in situ submergence observations, deep drilling and coring, and hydrate gas geochemical analyses, the geological and geophysical characteristics of these cold seep systems and their associated gas hydrate accumulations in the Qiongdongnan Basin, the Shenhu area, the Dongsha area, and the Taixinan Basin have been investigated. Cold seep systems are present in diverse stages of evolution and exhibit various seabed microgeomorphic, geological, and geochemical features. Active cold seep systems with a large amount of gas leakage, gas plumes, and microbial communities and inactive cold seep systems with authigenic carbonate pavements are related to the variable intensity of the gas-bearing fluid, which is usually derived from the deep strata through mud diapirs, mud volcanoes, gas chimneys, and faults. Gas hydrates are usually precipitated in cold seep vents and deeper vertical fluid migration pathways, indicating that deep gas-bearing fluid activities control the formation and accumulation of gas hydrates. The hydrocarbons collected from cold seep systems and their associated gas hydrate reservoirs are generally mixtures of biogenic gas and thermogenic gas, the origin of which is generally consistent with that of deep conventional gas. We also discuss the paragenetic relationship between the gas-bearing fluid and the seafloor morphology of cold seeps and the deep-shallow coupling of gas hydrates, cold seeps, and deep petroleum reservoirs. It is reasonable to conclude that the deep petroleum systems and gas-bearing fluid activity jointly control the development of cold seep systems and the accumulation of gas hydrates in the northern South China Sea. Therefore, the favorable areas for conventional oil and gas enrichment are also prospective areas for exploring active cold seeps and gas hydrates.
    Type of Medium: Online Resource
    ISSN: 1468-8123 , 1468-8115
    URL: Article
    DOI: 10.1155/2021/5571150
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2021
    detail.hit.zdb_id: 2045012-6
    SSG: 13
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  • 10
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    A Radiographic Study of Biomechanical Relationship between the Achilles Tendon and Plantar Fascia
    Hindawi Limited ; 2020
    In:  BioMed Research International Vol. 2020 ( 2020-02-18), p. 1-6
    Details
    In: BioMed Research International, Hindawi Limited, Vol. 2020 ( 2020-02-18), p. 1-6
    Abstract: Background . Previously, scholars have concluded that the Achilles tendon and the plantar fascia were closely biomechanically related, although there is little clinical evidence of the relationship between the two. To investigate the biomechanical relationship between the Achilles tendon and the plantar fascia, the author used standing lateral ankle radiographs of patients with insertional Achilles tendonitis to determine the biomechanical relationship between the Achilles tendon and plantar fascia. Methods . The author collected standing lateral ankle radiographs from patients with insertional Achilles tendonitis who accepted surgical treatment in the author’s hospital from March 2009 to July 2018. According to whether there were bone spurs on the posterior side of the calcaneus, patients were divided into group A (spur present on the posterior side) and group B (spur not present on the posterior side). The positive rates of spurs on the plantar side of the calcaneus were determined in group A and group B. The chi-square test was used to compare the measurement results between the two groups. Results . In group A, 13 heels were positive for calcaneal bone spurs, and the positive rate was 65.0%. In group B, 3 heels were positive for plantar calcaneal spurs, and the positive rate was 12%. Among all 16 patients with positive plantar calcaneal spurs, 13 had posterior calcaneal spurs (accounting for 81.3%), and 3 had negative results, accounting for 18.7%. There was a significant difference between the results in groups A and B ( P 〈 0.05 ). Conclusion . There is a relationship between posterior calcaneal spurs and plantar calcaneal spurs in patients with insertional Achilles tendonitis, which can be inferred as resulting from the increasing tension in the biomechanically complex relationship between the Achilles tendon and the plantar fascia.
    Type of Medium: Online Resource
    ISSN: 2314-6133 , 2314-6141
    URL: Article
    DOI: 10.1155/2020/5319640
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2020
    detail.hit.zdb_id: 2698540-8
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