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  • Hindawi Limited  (38)
  • 1
    Online Resource
    Online Resource
    Effect of Massage on the TLR4 Signalling Pathway in Rats with Neuropathic Pain
    Hindawi Limited ; 2020
    In:  Pain Research and Management Vol. 2020 ( 2020-12-16), p. 1-6
    Details
    In: Pain Research and Management, Hindawi Limited, Vol. 2020 ( 2020-12-16), p. 1-6
    Abstract: This study set out to investigate the effect of massage on the Toll-like receptor 4 (TLR4) signalling pathway in the dorsal root ganglia of rats that had undergone spinal nerve ligation (SNL), with the hypothesis that massage could be used as an analgesic. Forty female SD rats were randomly divided into 5 groups: the control group, sham-operated group, model group, sham massage group, and massage group. There were 8 rats in each group. SNL rat models were established in the model group, sham massage group, and massage group. Rats in the sham-operated group underwent surgery to expose the vertebral nerves, but no further procedures were performed. The control group consisted of intact animals. The rats in the massage group underwent massage using a massage simulation machine once a day for 14 d in succession; the hind limbs of the rats in the sham massage group were gently touched with a cloth bag once a day for 14 continuous days. The rats in the control group, the sham-operated group, and the model group did not receive any intervention and were observed for 14 d. Paw withdrawal thermal latency (PWTL) and paw withdrawal mechanical threshold (PWMT) of rats in each group were detected 1 d before modelling and at 1, 3, 7, and 14 d after modelling. Fourteen days after modelling, the expression levels of TLR4, IRAK1, TRAF6, TNF-α, and IL-6 were detected in all rats. The PWTL and PWMT of SNL rats were decreased, while these parameters were elevated after massage. SNL rats showed higher levels of TLR4, IRAK1, TRAF6, IL-6, and TNF-α, and massage effectively lowered the expression levels of these molecules. Inhibiting activation of the TLR4 signalling pathway, which can reduce the release of inflammatory factors, may be one mechanism by which massage treats neuropathic pain.
    Type of Medium: Online Resource
    ISSN: 1918-1523 , 1203-6765
    URL: Article
    DOI: 10.1155/2020/8309745
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2020
    detail.hit.zdb_id: 2048409-4
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  • 2
    Online Resource
    Online Resource
    Multifunctionalized Microscale Ultrasound Contrast Agents for Precise Theranostics of Malignant Tumors
    Hindawi Limited ; 2019
    In:  Contrast Media & Molecular Imaging Vol. 2019 ( 2019-07-07), p. 1-18
    Details
    In: Contrast Media & Molecular Imaging, Hindawi Limited, Vol. 2019 ( 2019-07-07), p. 1-18
    Abstract: In ultrasonography, ultrasound contrast agents (UCAs) that possess high acoustic impedance mismatch with the bulk medium are frequently employed to highlight the borders between tissues by enhanced ultrasound scattering in a clinic. Typically, the most common UCA, microbubble, is generally close in size to a red blood cell ( 〈 ∼10 μm). These microscale UCAs cannot be directly entrapped into the target cells but generate several orders of magnitude stronger echo signals than the nanoscale ones. And their large containment and high ultrasound responsiveness also greatly facilitate to perform combined treatments, e.g., drug delivery and other imaging techniques. So multifunctionalized microscale UCAs appear on this scene and keep growing toward a promising direction for precise theranostics. In this review, we systematically summarize the new advances in the principles and preparations of multifunctionalized microscale UCAs and their medical applications for malignant tumors.
    Type of Medium: Online Resource
    ISSN: 1555-4309 , 1555-4317
    URL: Article
    DOI: 10.1155/2019/3145647
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2019
    detail.hit.zdb_id: 2222967-X
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  • 3
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    MAIP1-Related Tumor Immune Infiltration: As a Potential Prognostic Biomarker for Esophageal Cancer
    Hindawi Limited ; 2022
    In:  Journal of Immunology Research Vol. 2022 ( 2022-6-14), p. 1-11
    Details
    In: Journal of Immunology Research, Hindawi Limited, Vol. 2022 ( 2022-6-14), p. 1-11
    Abstract: Background. Esophageal cancer (EC), a common malignant tumor of digestive tract, is also one of the most deadly cancers. Accumulating studies have shown that the initiating and progressing multiple human diseases were closely related to the expression of MAIP. However, the specific roles and mechanisms of MAIP1 in EC remain incompletely defined. Purpose. This study aims to determine the clinical significance of MAIP1 in EC and explores its potential molecular mechanisms regulating tumor immune infiltration. Methods. We obtained RNA-seq datasets and corresponding clinical data for EC patients from the Cancer Genome Atlas (TCGA) database via the UCSC Xena browser to extract MAIP1 expression and plot survival curves to determine their prognosis. Based on the differential expression of MAIP1, EC patients were divided into high and low group to investigate the mechanism of MAIP1 in EC. In addition, the single sample gene set enrichment analysis (ssGSEA) quantified the expression of various immune cell signature marker genes and assessed the degree of immune infiltration in EC. Results. In the TCGA-EC cohort, the overexpression of MAIP1 was observed in tumor tissues compared to normal tissues ( p = 0.0038 ). Overall survival analysis showed that EC patients with the overexpression of MAIP1 presented a lower overall survival and worse prognosis ( p = 0.004 ). Enrichment analysis revealed that the differential genes (DEGs) between high and low group are involved in biological functions such as extracellular matrix and organization extracellular structure. The results of ssGSEA showed that DCs, iDCs, macrophages, mast cells, and NK cells were significantly different in MAIP1high and MAIP1low groups, and all showed high expression in the MAIP1low group. Conclusion. We proposed that MAIP1 overexpression was associated with poor prognosis and tumor immune infiltration in EC. At present, there are few MAIP1-related tumor immune infiltration studies in EC, and further investigation is needed.
    Type of Medium: Online Resource
    ISSN: 2314-7156 , 2314-8861
    URL: Article
    DOI: 10.1155/2022/7282842
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2817541-4
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  • 4
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    Online Resource
    Application of Fractional Differential Calculation in Pretreatment of Saline Soil Hyperspectral Reflectance Data
    Hindawi Limited ; 2018
    In:  Journal of Sensors Vol. 2018 ( 2018-10-11), p. 1-12
    Details
    In: Journal of Sensors, Hindawi Limited, Vol. 2018 ( 2018-10-11), p. 1-12
    Abstract: Pretreatment of spectrum data is a necessary and effective method for improving the accuracy of hyperspectral model building. Traditional differential calculation pretreatment only considers the integer-order differential, such as the 1 st order and 2 nd order, and overlooks important spectrum information located at fractional order. Since fractional differential (FD) has rarely been applied to spectrum field measurement, there are few reports on the spectrum features of saline soils under different degrees of human interference. We used FD to analyze field spectrum data of saline soil collected from Xinjiang’s Fukang City. Order interval of 0.2 was adopted to divide 0–2 orders into 11-order differentials. MATLAB programming was used to convert the raw spectral reflectance and its four common types of mathematics and to conduct FD calculation. Spectrum data for area A (no human interference area) and area B (human interference area) was separately processed. From the statistical analysis of soil salinization characteristics, the salinization degree and type for area B were more diverse and complicated than area A. MATLAB simulation results showed that FD calculation could depict the minute differences between different FD order spectra under different human interference areas. The overall differential value trend appeared to move towards 0 reflectance value. After differential processing, the trend of bands that passed the 0.05 significance test of correlation coefficient ( C C ) showed an increase first then decrease later. The maximum C C absolute value for five spectrum transformations all appeared in the fractional order. FD calculation could significantly increase the correlation between spectral reflectance and soil salt content both for full-band and single-band spectra. Results of this study can serve as a reference for the application of FD in field hyperspectral monitoring of soil salinization for different human interference areas.
    Type of Medium: Online Resource
    ISSN: 1687-725X , 1687-7268
    URL: Article
    DOI: 10.1155/2018/8017614
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2018
    detail.hit.zdb_id: 2397931-8
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  • 5
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    Online Resource
    Identification of Potential Therapeutic Target Genes in Osteoarthritis
    Hindawi Limited ; 2022
    In:  Evidence-Based Complementary and Alternative Medicine Vol. 2022 ( 2022-8-13), p. 1-15
    Details
    In: Evidence-Based Complementary and Alternative Medicine, Hindawi Limited, Vol. 2022 ( 2022-8-13), p. 1-15
    Abstract: Objective. Osteoarthritis (OA), also known as joint failure, is characterized by joint pain and, in severe cases, can lead to loss of joint function in patients. Immune-related genes and immune cell infiltration play a crucial role in OA development. We used bioinformatics approaches to detect potential diagnostic markers and available drugs for OA while initially exploring the immune mechanisms of OA. Methods. The training set GSE55235 and validation set GSE51588 and GSE55457 were obtained from the Gene Expression Omnibus (GEO) database and differentially expressed genes (DEGs) were identified by the limma package. Gene set enrichment analysis (GSEA) was performed on the GSE55235 dataset using the cluster profiler package. At the same time, DEGs were analyzed by gene ontology (GO) and the Kyoto Encyclopedia of Genes and Genomes (KEGG). In addition, protein-protein interaction (PPI) analysis was performed on the common DEGs of the three datasets using the STRING database. Proteins with direct linkage were identified as hub genes, and the relation of hub genes was subsequently analyzed using the GOSemSim package. Hub genes’ expression profiles and diagnostic capabilities (ROC curves) were analyzed and validated using three datasets. In addition, we performed RT-qPCR to validate the levels of hub genes. The immune microenvironment was analyzed using the CIBERSORT package, and the relationship between hub genes and immune cells was evaluated. In addition, we used a linkage map (CMAP) database to identify available drug candidates. Finally, the GSEA of hub genes was used to decipher the potential pathways corresponding to hub genes. Results. Three hub genes (CX3CR1, MYC, and TLR7) were identified. CX3CR1 and TLR7 were highly expressed in patients with OA, whereas the expression of MYC was low. The results of RT-qPCR validation were consistent with those obtained using datasets. Among these genes, CX3CR1 and TLR7 can be used as diagnostic markers. It was found that CX3CR1, MYC, and TLR7 affect the immune microenvironment of OA via different immune cells. In addition, we identified a potential drug for the treatment of OA. Altogether, CX3CR1, MYC, and TLR7 affect the immune response of OA through multiple pathways. Conclusion. CX3CR1, MYC, and TLR7 are associated with various immune cells and are the potential diagnostic markers and therapeutic targets for OA.
    Type of Medium: Online Resource
    ISSN: 1741-4288 , 1741-427X
    URL: Article
    DOI: 10.1155/2022/8027987
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2148302-4
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  • 6
    Online Resource
    Online Resource
    Clearance of Free Silica in Rat Lungs by Spraying with Chinese Herbal Kombucha
    Hindawi Limited ; 2013
    In:  Evidence-Based Complementary and Alternative Medicine Vol. 2013 ( 2013), p. 1-9
    Details
    In: Evidence-Based Complementary and Alternative Medicine, Hindawi Limited, Vol. 2013 ( 2013), p. 1-9
    Abstract: The effects of spraying with kombucha and Chinese herbal kombucha were compared with treatments with tetrandrine in a rat silicosis model. Silica dust (50 mg) was injected into the lungs of rats, which were then treated with one of the experimental treatments for a month. The rats were then killed and the effects of the treatments were evaluated by examining the extent and severity of the histopathological lesions in the animals’ lungs, measuring their organ coefficients and lung collagen contents, determining the dry and wet weights of their lungs, and measuring the free silica content of the dried lungs. In addition, lavage was performed on whole lungs taken from selected rats, and the numbers and types of cells in the lavage fluid were counted. The most effective treatment in terms of the ability to reduce lung collagen content and minimize the formation of pulmonary histopathological lesions was tetrandrine treatment, followed by Chinese herbal kombucha and non-Chinese herbal kombucha. However, the lavage fluid cell counts indicated that tetrandrine treatment had severe adverse effects on macrophage viability. This effect was much less pronounced for the kombucha and Chinese herbal kombucha treatments. Moreover, the free silica levels in the lungs of animals treated with Chinese herbal kombucha were significantly lower than those for any other silica-exposed group. These preliminary results indicate that spraying with Chinese herbal kombucha preparations can effectively promote the discharge of silica dust from lung tissues. Chinese herbal kombucha inhalation may thus be a useful new treatment for silicosis and other pneumoconiosis diseases.
    Type of Medium: Online Resource
    ISSN: 1741-427X , 1741-4288
    URL: Article
    DOI: 10.1155/2013/790792
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2013
    detail.hit.zdb_id: 2148302-4
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  • 7
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    Online Resource
    Lie Group Solutions of Magnetohydrodynamics Equations and Their Well-Posedness
    Hindawi Limited ; 2016
    In:  Abstract and Applied Analysis Vol. 2016 ( 2016), p. 1-8
    Details
    In: Abstract and Applied Analysis, Hindawi Limited, Vol. 2016 ( 2016), p. 1-8
    Abstract: Based on classical Lie Group method, we construct a class of explicit solutions of two-dimensional ideal incompressible magnetohydrodynamics (MHD) equation by its infinitesimal generator. Via these explicit solutions we study the uniqueness and stability of initial-boundary problem on MHD.
    Type of Medium: Online Resource
    ISSN: 1085-3375 , 1687-0409
    URL: Article
    DOI: 10.1155/2016/8183079
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2016
    detail.hit.zdb_id: 2064801-7
    SSG: 17,1
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  • 8
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    Online Resource
    Novel interrupted aortic arch: A case report
    Hindawi Limited ; 2022
    In:  Journal of Cardiac Surgery Vol. 37, No. 12 ( 2022-12), p. 5639-5642
    Details
    In: Journal of Cardiac Surgery, Hindawi Limited, Vol. 37, No. 12 ( 2022-12), p. 5639-5642
    Type of Medium: Online Resource
    ISSN: 0886-0440 , 1540-8191
    URL: Issue
    URL: Article
    DOI: 10.1111/jocs.v37.12
    DOI: 10.1111/jocs.17223
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2108425-7
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  • 9
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    L actobacillus plantarum WCFS1 Fermentation Differentially Affects Antioxidant Capacity and Polyphenol Content in Mung bean ( Vigna radiata ) and Soya Bean ( Glycine max ) Milks : Antioxidant Polyphenols in Fermented Bean Milks
    Hindawi Limited ; 2017
    In:  Journal of Food Processing and Preservation Vol. 41, No. 1 ( 2017-02), p. e12944-
    Details
    In: Journal of Food Processing and Preservation, Hindawi Limited, Vol. 41, No. 1 ( 2017-02), p. e12944-
    Type of Medium: Online Resource
    ISSN: 0145-8892
    URL: Issue
    URL: Article
    DOI: 10.1111/jfpp.2017.41.issue-1
    DOI: 10.1111/jfpp.12944
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2017
    detail.hit.zdb_id: 2175273-4
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  • 10
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    Inhibitory effect of chitosan‐based coating on the deterioration of muscle quality of Pacific white shrimp at 4°C storage
    Hindawi Limited ; 2021
    In:  Journal of Food Processing and Preservation Vol. 45, No. 2 ( 2021-02)
    Details
    In: Journal of Food Processing and Preservation, Hindawi Limited, Vol. 45, No. 2 ( 2021-02)
    Type of Medium: Online Resource
    ISSN: 0145-8892 , 1745-4549
    URL: Issue
    URL: Article
    DOI: 10.1111/jfpp.v45.2
    DOI: 10.1111/jfpp.15167
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2021
    detail.hit.zdb_id: 2175273-4
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