In:
FEBS Letters, Wiley, Vol. 177, No. 1 ( 1984-11-05), p. 89-94
Abstract:
Turpentine injection into rats elicits enhanced secretion of acute phase proteins inducing α 2 ‐macroglobulin (α 2 M). Hypophysectomized rats, however, do not respond in this way unless dexamethasone is given together with turpentine. On the other hand, dexamethasone injection alone did not result in an induction of α 2 M synthesis. When a medium of Kupffer cell cultures was added to hepatocytes, a dose‐dependent stimulation of α 2 M synthesis of up to 4‐fold after 10–12 h was observed. However, the presence of low concentrations (10 −9 M) of dexamethasone was essential for the stimulatory effect. We conclude that the acute phase induction of α 2 M in hepatocytes requires the synergistic action of glucocorticoids and a non‐dialysable factor secreted by Kupffer cells.
Type of Medium:
Online Resource
ISSN:
0014-5793
,
1873-3468
DOI:
10.1016/0014-5793(84)80987-4
Language:
English
Publisher:
Wiley
Publication Date:
1984
detail.hit.zdb_id:
1460391-3
SSG:
12
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