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  • 11
    Online Resource
    Online Resource
    Research on the Collapse Coefficient of Collapsible Loess under Unloading
    Hindawi Limited ; 2021
    In:  Advances in Civil Engineering Vol. 2021 ( 2021-2-13), p. 1-12
    Details
    In: Advances in Civil Engineering, Hindawi Limited, Vol. 2021 ( 2021-2-13), p. 1-12
    Abstract: In the geogenetic overburden excavation of underground space projects (such as comprehensive pipe corridors or subways), the foundation stress is in an unloading state. The effect(s) from the unloading on the coefficient of subsidence in the loess area should be considered. In this study, to explore the effect of unloading on the collapsibility of loess, the collapsible loess in the Guanzhong area was considered as the research object. An expression for the unloading collapse coefficient was established based on the unloading stress ratio, unloading collapse ratio, and other parameters. The influence of the unloading on the loess collapse coefficient was studied using an indoor collapsibility test, and the function form and parameters for the expression were determined. As combined with the field test, the accuracy of the expression for the unloading coefficient was verified based on the test value for the specific collapsibility, calculated value for the specific collapsibility, and calculated value for the unloading collapsibility.
    Type of Medium: Online Resource
    ISSN: 1687-8094 , 1687-8086
    URL: Article
    DOI: 10.1155/2021/6672301
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2021
    detail.hit.zdb_id: 2449760-5
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  • 12
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    Identification of Immune-Related Risk Signatures for the Prognostic Prediction in Oral Squamous Cell Carcinoma
    Hindawi Limited ; 2021
    In:  Journal of Immunology Research Vol. 2021 ( 2021-8-25), p. 1-13
    Details
    In: Journal of Immunology Research, Hindawi Limited, Vol. 2021 ( 2021-8-25), p. 1-13
    Abstract: Background. Oral squamous cell carcinoma (OSCC) is the most common type of oral cancer, which remains a major cause of morbidity and mortality in patients with head and neck cancers. However, the critical immune-related signatures and their prognostic values have rarely been investigated. Materials and Methods. Gene differential analysis was used to measure the differences of gene expression between the groups. Correlation analysis was used to assess the association between the gene expression levels and immune-related risk score/DNA methylation levels. The gene set enrichment analysis (GSEA) was used to identify the pathways or cell types enriched by those identified differentially expressed genes (DEGs). Results. In this study, we identified four immune-related gene signatures, including CTSG, TNFRSF4, LCORL, and PLAU, that were significantly associated with the overall survival in OSCC patients from the Cancer Genome Atlas (TCGA) OSCC cohort. Moreover, these four immune-related signatures were differentially expressed between the OSCC and nontumor tissues. The two groups (high and low risk) stratified by the immune-related risk scores had significantly different OS and mortality rates. The gene expression patterns and prognostic values of these immune-related signatures were also verified in two independent validation cohorts. Furthermore, the downregulated genes in the high-risk group (which were also upregulated in the low-risk group) were significantly enriched in the cell type-specific signatures of type 2 T helper cell (Th2), plasmacytoid dendritic cell (pDC), and memory B cell. In contrast, the upregulated genes in the high-score group were enriched in growth factor receptor-related signaling pathways, such as the VEGFA-VEGFR2 signaling pathway, PI3K-Akt signaling pathway, focal adhesion-PI3K-Akt-mTOR signaling pathway, and PDGF pathway, suggesting that those pathways were inversely correlated with immune cell infiltration. Conclusion. In summary, the immune-related signatures had the potential for predicting the risk of OSCC patients. Moreover, the present study also improved our understanding of the association between the growth factor receptor pathways and immune cell infiltration in OSCC.
    Type of Medium: Online Resource
    ISSN: 2314-7156 , 2314-8861
    URL: Article
    DOI: 10.1155/2021/6203759
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2021
    detail.hit.zdb_id: 2817541-4
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  • 13
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    Online Resource
    Two Myricetin-Derived Flavonols from Morella rubra Leaves as Potent α-Glucosidase Inhibitors and Structure-Activity Relationship Study by Computational Chemistry
    Hindawi Limited ; 2022
    In:  Oxidative Medicine and Cellular Longevity Vol. 2022 ( 2022-4-19), p. 1-16
    Details
    In: Oxidative Medicine and Cellular Longevity, Hindawi Limited, Vol. 2022 ( 2022-4-19), p. 1-16
    Abstract: Diabetes mellitus (DM) is a chronic disease characterized by hyperglycemia, and oxidative stress is an important cause and therapeutic target of DM. Phytochemicals such as flavonols are important natural antioxidants that can be used for prevention and treatment of DM. In the present study, six flavonols were precisely prepared and structurally elucidated from Morella rubra leaves, which were screened based on antioxidant assays and α-glucosidase inhibitory activities of different plant tissues. Myricetin-3-O-(2″-O-galloyl)-α-L-rhamnoside (2) and myricetin-3-O-(4″-O-galloyl)-α-L-rhamnoside (3) showed excellent α-glucosidase inhibitory effects with IC50 values of 1.32 and 1.77 μM, respectively, which were hundredfold higher than those of positive control acarbose. Molecular docking simulation illustrated that the presence of galloyl group altered the binding orientation of flavonols, where it occupied the opening of the cavity pocket of α-glucosidase along with Pi-anion interaction with Glu304 and Pi-Pi stacked with His279. Pi-conjugations generated between galloyl moiety and key residues at the active site of α-glucosidase reinforced the flavonol-enzyme binding, which might explain the greatly increased activity of compounds 2 and 3. In addition, 26 flavonols were evaluated for systematic analysis of structure-activity relationship (SAR) between flavonols and α-glucosidase inhibitory activity. By using their pIC50 (-log IC50) values, three-dimensional quantitative SAR (3D-QSAR) models were developed via comparative molecular field analysis (CoMFA) and comparative similarity index analysis (CoMSIA), both of which were validated to possess high accuracy and predictive power as indicated by the reasonable cross-validated coefficient ( q 2 ) and non-cross-validated coefficient ( r 2 ) values. Through analyzing 3D contour maps of both CoMFA and CoMSIA models, QSAR results were in agreement with in vitro experimental data. Therefore, such results showed that the galloyl group in compounds 2 and 3 is crucial for interacting with key residues of α-glucosidase and the established 3D-QSAR models could provide valuable information for the prediction of flavonols with great antidiabetic potential.
    Type of Medium: Online Resource
    ISSN: 1942-0994 , 1942-0900
    URL: Article
    DOI: 10.1155/2022/9012943
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2455981-7
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  • 14
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    Online Resource
    Effect of Ca Concentration on Microstructure and Mechanical Properties of As-Cast and As-Extruded Quasicrystal-Strengthened Mg-7.2Zn-2.4Gd Alloy
    Hindawi Limited ; 2018
    In:  Advances in Materials Science and Engineering Vol. 2018 ( 2018-10-15), p. 1-7
    Details
    In: Advances in Materials Science and Engineering, Hindawi Limited, Vol. 2018 ( 2018-10-15), p. 1-7
    Abstract: Quasicrystal-strengthened Mg-Zn-RE (RE = rare-earth element) alloys have been investigated extensively due to their excellent mechanical properties. Here, we prepare quasicrystal-strengthened Mg-7.2Zn-2.4Gd (wt.%) alloy with different concentrations of Ca addition (0, 0.16, 0.32, and 0.64 wt.%) by traditional gravity casting, followed by extrusion at 573 K with the extrusion ratio of 9 : 1. The microstructure and room temperature tensile properties of as-cast and as-extruded alloys are characterized. With the addition of the trace amount of Ca, the I-phase tends to transfer into W-phase due to the appearance of Mg 2 Ca and Mg 6 Zn 3 Ca 2 . As a consequence, the mechanical properties of the as-cast Ca containing alloys are downgraded. After extrusion, in comparison to the as-cast alloys, microstructure of the four types of alloys is refined and mechanical property is enhanced greatly. With the increasing of Ca concentration, the grain size is decreased gradually. However, the yield strength of the alloys is decreased to about 230 MPa and then up to 269 MPa, while the elongation increases first from 12.9% to 13.6% yet then decreases to 9.9%.
    Type of Medium: Online Resource
    ISSN: 1687-8434 , 1687-8442
    URL: Article
    DOI: 10.1155/2018/9138753
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2018
    detail.hit.zdb_id: 2501025-6
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  • 15
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    The Correlation between Gut Microbiota and Serum Metabolomic in Elderly Patients with Chronic Heart Failure
    Hindawi Limited ; 2021
    In:  Mediators of Inflammation Vol. 2021 ( 2021-10-27), p. 1-13
    Details
    In: Mediators of Inflammation, Hindawi Limited, Vol. 2021 ( 2021-10-27), p. 1-13
    Abstract: Objective. Chronic heart failure (CHF) refers to a state of persistent heart failure that can be stable, deteriorated, or decompensated. The mechanism and pathogenesis of myocardial remodeling remain unknown. Based on 16S rDNA sequencing and metabolomics technology, this study analyzed the gut microbiota and serum metabolome in elderly patients with CHF to provide new insights into the microbiota and metabolic phenotypes of CHF. Methods. Blood and fecal samples were collected from 25 elderly patients with CHF and 25 healthy subjects. The expression of inflammatory factors in blood was detected by ELISA. 16S rDNA sequencing was used to analyze the changes in microorganisms in the samples. The changes of small molecular metabolites in serum samples were analyzed by LC-MS/MS. Spearman correlation coefficients were used to analyze the correlation between gut microbiota and serum metabolites. Results. Our results showed that the IL-6, IL-8, and TNF-α levels were significantly increased, and the IL-10 level was significantly decreased in the elderly patients with CHF compared with the healthy subjects. The diversity of the gut microbiota was decreased in the elderly patients with CHF. Moreover, Escherichia Shigella was negatively correlated with biocytin and RIBOFLAVIN. Haemophilus was negatively correlated with alpha-lactose, cellobiose, isomaltose, lactose, melibiose, sucrose, trehalose, and turanose. Klebsiella was positively correlated with bilirubin and ethylsalicylate. Klebsiella was negatively correlated with citramalate, hexanoylcarnitine, inosine, isovalerylcarnitine, methylmalonate, and riboflavin. Conclusion. The gut microbiota is simplified by the disease, and serum small-molecule metabolites evidently change in elderly patients with CHF. Serum and fecal biomarkers could be used for elderly patients with CHF screening.
    Type of Medium: Online Resource
    ISSN: 1466-1861 , 0962-9351
    URL: Article
    DOI: 10.1155/2021/5587428
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2021
    detail.hit.zdb_id: 2008065-7
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  • 16
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    lncRNA DCST1-AS1 Facilitates Oral Squamous Cell Carcinoma by Promoting M2 Macrophage Polarization through Activating NF-κB Signaling
    Hindawi Limited ; 2021
    In:  Journal of Immunology Research Vol. 2021 ( 2021-8-8), p. 1-9
    Details
    In: Journal of Immunology Research, Hindawi Limited, Vol. 2021 ( 2021-8-8), p. 1-9
    Abstract: lncRNAs are related to the progression of various diseases, including oral squamous cell carcinoma (OSCC), which is a common squamous cell carcinoma of the head and neck. Tumor-associated macrophages and tumor cells are significant components of tumor microenvironment. M2 polarization of tumor-associated macrophages is a crucial actor in tumor malignancy and metastasis. In this study, we studied the molecular mechanism of lncRNA DCST1-AS1 in OSCC. Here, we reported that DCST1-AS1 was significantly increased in OSCC cells. We found that loss of DCST1-AS1 obviously inhibited the proliferation, migration, and invasion of OSCC cells and xenograft tumor growth. Meanwhile, silencing of DCST1-AS1 also repressed the percentage of macrophages expressing M2 markers CD206 and CD11b. DCST1-AS1 shRNA enhanced the percentage of macrophages expressing M1 markers CD80 and CD11c. Then, we observed that loss of DCST1-AS1 suppressed OSCC progression via inactivating NF-κB signaling. As well established, NF-κB signaling exerts critical roles in tumor progression, and our study proved that DCST1-AS1 could regulate NF-κB signaling. We proved that blocking the NF-κB pathway using antagonists greatly downregulated OSCC progression and M2 macrophage polarization induced by the overexpression of DCST1-AS1. To sum up, we reported that DCST1-AS1 plays an important role in modulating OSCC tumorigenicity and M2 macrophage polarization through regulating the NF-κB pathway.
    Type of Medium: Online Resource
    ISSN: 2314-7156 , 2314-8861
    URL: Article
    DOI: 10.1155/2021/5524231
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2021
    detail.hit.zdb_id: 2817541-4
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  • 17
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    Online Resource
    SAMHD1 Gene Mutations Are Associated with Cerebral Large-Artery Atherosclerosis
    Hindawi Limited ; 2015
    In:  BioMed Research International Vol. 2015 ( 2015), p. 1-8
    Details
    In: BioMed Research International, Hindawi Limited, Vol. 2015 ( 2015), p. 1-8
    Abstract: Background . To investigate whether one or more SAMHD1 gene mutations are associated with cerebrovascular disease in the general population using a Chinese stroke cohort. Methods . Patients with a Chinese Han background ( N = 300 ) diagnosed with either cerebral large-artery atherosclerosis (LAA, n = 100 ), cerebral small vessel disease (SVD, n = 100 ), or other stroke-free neurological disorders (control, n = 100 ) were recruited. Genomic DNA from the whole blood of each patient was isolated, and direct sequencing of the SAMHD1 gene was performed. Both wild type and mutant SAMHD1 proteins identified from the patients were expressed in E. coli and purified; then their dNTPase activities and ability to form stable tetramers were analysed in vitro . Results . Three heterozygous mutations, including two missense mutations c.64C 〉 T (P22S) and c.841G 〉 A (p.E281K) and one splice site mutation c.696+2T 〉 A, were identified in the LAA group with a prevalence of 3%. No mutations were found in the patients with SVD or the controls ( p = 0.05 ). The mutant SAMHD1 proteins were functionally impaired in terms of their catalytic activity as a dNTPase and ability to assemble stable tetramers. Conclusions . Heterozygous SAMHD1 gene mutations might cause genetic predispositions that interact with other risk factors, resulting in increased vulnerability to stroke.
    Type of Medium: Online Resource
    ISSN: 2314-6133 , 2314-6141
    URL: Article
    DOI: 10.1155/2015/739586
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2015
    detail.hit.zdb_id: 2698540-8
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  • 18
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    Smart Polymeric Nanocarriers
    Hindawi Limited ; 2016
    In:  Journal of Nanomaterials Vol. 2016 ( 2016), p. 1-2
    Details
    In: Journal of Nanomaterials, Hindawi Limited, Vol. 2016 ( 2016), p. 1-2
    Type of Medium: Online Resource
    ISSN: 1687-4110 , 1687-4129
    URL: Article
    DOI: 10.1155/2016/3710921
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2016
    detail.hit.zdb_id: 2229480-6
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  • 19
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    Adaptive Dynamic Surface Integral Sliding Mode Fault-Tolerant Control for Multimachine Excitation Systems with SVC
    Hindawi Limited ; 2020
    In:  Complexity Vol. 2020 ( 2020-11-3), p. 1-21
    Details
    In: Complexity, Hindawi Limited, Vol. 2020 ( 2020-11-3), p. 1-21
    Abstract: In this paper, an adaptive dynamic surface integral sliding mode fault-tolerant controller is designed for the multimachine power system with static var compensator (SVC) to overcome the problem of actuator failure. The main features of the proposed method are as follows: (1) By combining the dynamic surface control (DSC) method with integral sliding mode (ISM), the tracking errors of the system converge to the neighborhood of zero within a finite time, and the convergence speed, tracking accuracy, and anti-interference ability of the system are also significantly improved. (2) By introducing the failure factors, an adaptive fault-tolerant controller is designed to ensure the stability of the entire system after partial failure of the actuator. (3) By estimating the norm of the ideal weight vector of the radial basis function neural networks (RBFNNs), the computational burden of the controller is reduced. Finally, the simulation results show the effectiveness of the proposed control scheme.
    Type of Medium: Online Resource
    ISSN: 1099-0526 , 1076-2787
    URL: Article
    DOI: 10.1155/2020/6106794
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2020
    detail.hit.zdb_id: 2004607-8
    SSG: 11
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  • 20
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    CircMAT2B Induced by TEAD1 Aggravates the Warburg Effect and Tumorigenesis of Oral Squamous Cell Carcinoma through the miR-942-5p/HSPD1 Axis
    Hindawi Limited ; 2022
    In:  Journal of Oncology Vol. 2022 ( 2022-8-16), p. 1-14
    Details
    In: Journal of Oncology, Hindawi Limited, Vol. 2022 ( 2022-8-16), p. 1-14
    Abstract: Oral squamous cell carcinoma (OSCC) is one of the most lethal cancers worldwide. The high morbidity and mortality of OSCC are a great burden to global health-care systems. Therefore it is important to understand the underlying molecular mechanisms of OSCC initiation and progression. This study aimed to investigate the role of circMAT2B in OSCC progression and its molecular mechanisms. First, the expression and circularization of circMAT2B in OSCC cells were verified. Subsequently, knockdown of circMAT2B was shown to inhibit OSCC cell proliferation, migration, invasion, and the Warburg effect. Bioinformatics prediction, RNA-pull down, and luciferase reporter gene assays led to the identification of a novel TEAD1/circMAT2B/miR-942-5p/HSPD1 axis in OSCC progression. In conclusion, the novel TEAD1/circMAT2B/miR-942-5p/HSPD1 axis is a potential target for OSCC.
    Type of Medium: Online Resource
    ISSN: 1687-8469 , 1687-8450
    URL: Article
    DOI: 10.1155/2022/7574458
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2022
    detail.hit.zdb_id: 2461349-6
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