In:
BioMed Research International, Hindawi Limited, Vol. 2014 ( 2014), p. 1-7
Kurzfassung:
Background/Aims . Previous studies have reported p-cresyl sulfate (PCS) was related to endothelial dysfunction and adverse clinical effect. We investigate the adverse effects of PCS on clinical outcomes in a chronic kidney disease (CKD) cohort study. Methods . 72 predialysis patients were enrolled from a single medical center. Serum biochemistry data and PCS were measured. The clinical outcomes including cardiovascular event, all-cause mortality, and dialysis event were recorded during a 3-year follow-up. Results . After adjusting other independent variables, multivariate Cox regression analysis showed age (HR: 1.12, P = 0.01 ), cardiovascular disease history (HR: 6.28, P = 0.0 2 ), and PCS (HR: 1.12, P = 0.0 2 ) were independently associated with cardiovascular event; age (HR: 0.91, P 〈 0.01 ), serum albumin (HR: 0.03, P 〈 0.01 ), and PCS level (HR: 1.17, P 〈 0.01 ) reached significant correlation with dialysis event. Kaplan-Meier analysis revealed that patients with higher serum p-cresyl sulfate ( 〉 6 mg/L) were significantly associated with cardiovascular and dialysis event (log rank P = 0.0 3 , log rank P 〈 0.01 , resp.). Conclusion . Our study shows serum PCS could be a valuable marker in predicting cardiovascular event and renal function progression in CKD patients without dialysis.
Materialart:
Online-Ressource
ISSN:
2314-6133
,
2314-6141
Sprache:
Englisch
Verlag:
Hindawi Limited
Publikationsdatum:
2014
ZDB Id:
2698540-8
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