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  • 1
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    Anti-Inflammatory Effect of 1,3,5,7-Tetrahydroxy-8-isoprenylxanthone Isolated from Twigs of Garcinia esculenta on Stimulated Macrophage (2015)
    Hindawi
    Details
    Publication Date: 2015-10-12
    Description: Garcinia Linn. plants having rich natural xanthones and benzophenones with anti-inflammatory activity attracted a great deal of attention to discover and develop them as potential drug candidates. Through screening targeting nitric oxide accumulation in stimulated macrophage, we found that 1,3,5,7-tetrahydroxy-8-isoprenylxanthone (TIE) had potential anti-inflammatory effect. To understand how TIE elicits its anti-inflammatory activity, we uncovered that it significantly inhibits the production of nitric oxide (NO) and prostaglandin E2 (PGE2) in LPS/IFNγ-stimulated RAW264.7 cells. In further study, we showed that TIE reduced the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2), two key molecules responsible for the production of NO and PGE2 during inflammation progress. Additionally, TIE also suppressed the expression of inflammatory cytokines IL-6, IL-12, and TNF-α. TIE-led suppression in iNOS, COX-2, and cytokines production were probably the consequence of TIE’s capability to block ERK and p38MAPK signaling pathway. Moreover, TIE blocked activation of nuclear factor-kappa B (NF-κB) as well as NF-κB regulation of miR155 expression. Our study suggests that TIE may represent as a potential therapeutic agent for the treatment of inflammatory diseases.
    Print ISSN: 0962-9351
    Electronic ISSN: 1466-1861
    Topics: Medicine
    Published by Hindawi
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  • 2
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    Patch Similarity Modulus and Difference Curvature Based Fourth-Order Partial Differential Equation for Image Denoising (2015)
    Hindawi
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    Publication Date: 2015-07-31
    Description: The traditional fourth-order nonlinear diffusion denoising model suffers the isolated speckles and the loss of fine details in the processed image. For this reason, a new fourth-order partial differential equation based on the patch similarity modulus and the difference curvature is proposed for image denoising. First, based on the intensity similarity of neighbor pixels, this paper presents a new edge indicator called patch similarity modulus, which is strongly robust to noise. Furthermore, the difference curvature which can effectively distinguish between edges and noise is incorporated into the denoising algorithm to determine the diffusion process by adaptively adjusting the size of the diffusion coefficient. The experimental results show that the proposed algorithm can not only preserve edges and texture details, but also avoid isolated speckles and staircase effect while filtering out noise. And the proposed algorithm has a better performance for the images with abundant details. Additionally, the subjective visual quality and objective evaluation index of the denoised image obtained by the proposed algorithm are higher than the ones from the related methods.
    Print ISSN: 1024-123X
    Electronic ISSN: 1563-5147
    Topics: Mathematics , Technology
    Published by Hindawi
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  • 3
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    Research on Spillover Effects for Vibration Control of Piezoelectric Smart Structures by ANSYS (2014)
    Hindawi
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    Publication Date: 2014-04-03
    Description: To control vibration of a piezoelectric smart structure, a controller is usually designed based on a reduced order model (ROM) of the system. When such a ROM based controller operates in closed loop with the actual structure, spillover phenomenon occurs because the unmodeled dynamics, which are not included in ROM, will be excited. In this paper, a new approach aiming at investigating spillover effects in ANSYS software is presented. By using the ANSYS parametric design language (APDL), the ROM based controller is integrated into finite element model to provide an accurate representation of what will happen when the controller is connected to the real plant. Therefore, the issues of spillover effects can be addressed in the closed loop simulation. Numerical examples are presented for investigating spillover effects of a cantilever piezoelectric plate subjected to various types of loading. The importance of considering spillover effects in closed loop simulation of piezoelectric smart structures is demonstrated. Moreover, the present study may provide an efficient method especially beneficial for preliminary design of piezoelectric smart structure to evaluate the performance of candidate control laws in finite element environment considering spillover effects.
    Print ISSN: 1024-123X
    Electronic ISSN: 1563-5147
    Topics: Mathematics , Technology
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  • 4
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    Throughput Optimization via Cooperative Spectrum Sensing with Novel Frame Structure (2013)
    Hindawi
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    Publication Date: 2013-12-09
    Description: In cognitive radio (CR) networks, cooperation can greatly improve the performance of spectrum sensing. In this paper, we propose a novel cooperative spectrum sensing (CSS) frame structure in which CR users conduct spectrum sensing and data transmission concurrently over two different parts of the primary user (PU) spectrum band. Energy detection sensing scheme is used to prove that there exists an optimal sensing bandwidth which yields the highest throughput for the CR network. Thus, we focus on the optimal sensing settings of the proposed sensing scheme in order to maximize the throughput of the CR network under the conditions of sufficient protection to PUs and required bandwidth for potential CR user data transmission. Some algorithms are also derived to jointly optimize the sensing bandwidth and the final decision threshold. Our simulation results show that optimizing the sensing bandwidth and the final decision threshold together will further increase the throughput of the CR network as compared to that which only optimizes the sensing bandwidth or the final decision threshold.
    Print ISSN: 1024-123X
    Electronic ISSN: 1563-5147
    Topics: Mathematics , Technology
    Published by Hindawi
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  • 5
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    An Efficient Spectral Element Model with Electric DOFs for the Static and Dynamic Analysis of a Piezoelectric Bimorph (2014)
    Hindawi
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    Publication Date: 2014-04-25
    Description: An efficient spectral element (SE) model for static and dynamic analysis of a piezoelectric bimorph is proposed. It combines an equivalent single layer (ESL) model for the mechanical displacement field with a sublayer approximation for the electric potential. The 2D Gauss-Lobatto-Legendre (GLL) shape functions are used to discretize the displacements and then the governing equation of motion is derived following the standard SE method procedure. It is shown numerically that the present SE model can well predict both the global and local responses such as mechanical displacements, natural frequencies, and the electric potentials across the bimorph thickness. In the case of bimorph sensor application, it is revealed that the distribution of the induced electric potential across the thickness does not affect the global natural frequencies much. Furthermore, the effects of the order of Legendre polynomial and the mesh size on the convergence rate are investigated. Comparison of the present results for a bimorph sensor with those from 3D finite element (FE) simulations establishes that the present SE model is accurate, robust, and computationally efficient.
    Print ISSN: 1024-123X
    Electronic ISSN: 1563-5147
    Topics: Mathematics , Technology
    Published by Hindawi
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  • 6
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    Attribute Analysis of Aridity Variability in North Xinjiang, China (2016)
    Hindawi
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    Publication Date: 2016-05-30
    Description: Identifying the dominant meteorological factors affecting aridity variability can improve our understanding of climate change and its future trend in arid and semiarid regions. This study investigated the spatiotemporal aridity variability in North Xinjiang, China, from 1961 to 2013, based on the UNESCO aridity index (precipitation/potential evapotranspiration), and analyzed its association with meteorological factors. The results suggest that North Xinjiang is becoming more humid with an increasing trend in aridity index. Precipitation, temperature, and relative humidity have positive correlation with aridity, and evapotranspiration, sunshine hours, and wind speed have negative correlation with aridity. Wind speed and sunshine hours have a higher sensitivity and more contribution to aridity. This study provides an understanding of the effect of recent climate change on drought in northwest China.
    Print ISSN: 1687-9309
    Electronic ISSN: 1687-9317
    Topics: Geosciences , Physics
    Published by Hindawi
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  • 7
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    Interferon Treatment of Hepatitis C Reinfection after Liver Transplantation: A Meta-Analysis (2015)
    Hindawi
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    Publication Date: 2015-06-19
    Description: Background. Graft reinfection with hepatitis C (HCV) after liver transplantation is a significant problem in transplant hepatology. This meta-analysis was performed to compare the effectiveness and risk of adverse events of interferon-based therapy with no treatment after liver transplantation. Methods. We searched electronic databases up to July 31, 2013, to obtain relevant research reports that satisfied the inclusion criteria. Meta-analyses were done on randomized controlled trials (RCTs) and nonrandomized trials. Results. A meta-analysis was performed on 2 RCTs and 2 cohort studies comprising a total of 326 patients (171 of whom accepted interferon-based antiviral therapy). The treatment group was found to have higher virological response (VR) rates than controls at 12, 24, 48, and 72 weeks. Patients in the antiviral group had higher sustained virological response (SVR) rates and lower mean alanine aminotransferase levels relative to controls at 48 weeks, but more total serious adverse events (AEs) than controls. Conclusions. Interferon-based treatment has some efficacy in the treatment of HCV graft reinfection following liver transplantation.
    Print ISSN: 1687-6121
    Electronic ISSN: 1687-630X
    Topics: Medicine
    Published by Hindawi
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  • 8
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    Correlations of Ezrin Expression with Pathological Characteristics and Prognosis of Osteosarcoma: A Meta-Analysis (2014)
    Hindawi
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    Publication Date: 2014-11-28
    Description: We conducted a meta-analysis to comprehensively evaluate the correlations of ezrin expression with pathological characteristics and the prognosis of osteosarcoma. The MEDLINE (1966–2013), the Cochrane Library Database, EMBASE, CINAHL, Web of Science (1945–2013), and the Chinese Biomedical Database were searched without language restrictions. Meta-analyses conducted using STATA software were calculated. Ten studies met the inclusion criteria, including 459 patients with osteosarcoma. Meta-analysis results illustrated that ezrin expression may be closely associated with the recurrence of osteosarcoma or metastasis in osteosarcoma. Our findings also demonstrated that patients with grade III-IV osteosarcoma showed a higher frequency of ezrin expression than those with histological grade I-II osteosarcoma. Furthermore, we found that patients with positive expression of ezrin exhibited a shorter overall survival than those with negative ezrin expression. The results also indicated that positive ezrin expression was strongly correlated with poorer metastasis-free survival. Nevertheless, no significant relationships were observed between ezrin expression and clinical variables (age and gender). In the current meta-analysis, our results illustrated significant relationships of ezrin expression with pathological characteristics and prognosis of osteosarcoma. Thus, ezrin expression could be a promising marker in predicting the clinical outcome of patients with osteosarcoma.
    Electronic ISSN: 1537-744X
    Topics: Natural Sciences in General
    Published by Hindawi
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  • 9
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    Application of a New Membership Function in Nonlinear Fuzzy PID Controllers with Variable Gains (2014)
    Hindawi
    Details
    Publication Date: 2014-08-29
    Description: This paper proposes a nonlinear fuzzy PID control algorithm, whose membership function (MF) is adjustable, is universal, and has a wide adjustable range. Appling this function to fuzzy control theory will increase system’s tunability. The continuity of this function is proved. This method was employed in the simulation and HIL experiments. Effectiveness and feasibility of this function are demonstrated in the results.
    Print ISSN: 1110-757X
    Electronic ISSN: 1687-0042
    Topics: Mathematics
    Published by Hindawi
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