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  • Nature Publishing Group (NPG)  (6)
  • Hindawi  (5)
  • Institute of Physics (IOP)  (2)
  • 1
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    Rho/MRTF-A-Induced Integrin Expression Regulates Angiogenesis in Differentiated Multipotent Mesenchymal Stem Cells (2015)
    Hindawi
    Details
    Publication Date: 2015-04-09
    Description: Mesenchymal stem cells (MSCs) are known to undergo endothelial differentiation in response to treatment with vascular endothelial growth factor (VEGF), but their angiogenic ability is poorly characterized. In the present study, we aimed to further investigate the role of Rho/MRTF-A in angiogenesis by MSCs and the effect of the Rho/MRTF-A pathway on the expression of integrins α1β1 and α5β1, which are known to mediate physiological and pathological angiogenesis. Our results showed that increased expression of α1, α5, and β1 was observed during angiogenesis of differentiated MSCs, and the Rho/MRTF-A signaling pathway was demonstrated to be involved in regulating the expression of integrins α1, α5, and β1. Luciferase reporter assay and ChIP assay determined that MRTF-A could bind to and transactivate the integrin α1 and α5 promoters. Treatment with the Rho inhibitor C3 transferase, the Rho-associated protein kinase (ROCK) inhibitor Y27632 or with shMRTF-A inhibited both the upregulation of α1, α5, and β1 as well as angiogenesis. Furthermore, in human umbilical vein endothelial cells (HUVECs), MRTF-A deletion led to marked reductions in cell migration and vessel network formation compared with the control. These data demonstrate that Rho/MRTF-A signaling is an important mediator that controls integrin gene expression during MSC-mediated angiogenic processes.
    Electronic ISSN: 1687-9678
    Topics: Medicine
    Published by Hindawi
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  • 2
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    Using Software Dependency to Bug Prediction (2013)
    Hindawi
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    Publication Date: 2013-10-02
    Description: Software maintenance, especially bug prediction, plays an important role in evaluating software quality and balancing development costs. This study attempts to use several quantitative network metrics to explore their relationships with bug prediction in terms of software dependency. Our work consists of four main steps. First, we constructed software dependency networks regarding five dependency scenes at the class-level granularity. Second, we used a set of nine representative and commonly used metrics—namely, centrality, degree, PageRank, and HITS, as well as modularity—to quantify the importance of each class. Third, we identified how these metrics were related to the proneness and severity of fixed bugs in Tomcat and Ant and determined the extent to which they were related. Finally, the significant metrics were considered as predictors for bug proneness and severity. The result suggests that there is a statistically significant relationship between class’s importance and bug prediction. Furthermore, betweenness centrality and out-degree metric yield an impressive accuracy for bug prediction and test prioritization. The best accuracy of our prediction for bug proneness and bug severity is up to 54.7% and 66.7% (top 50, Tomcat) and 63.8% and 48.7% (top 100, Ant), respectively, within these two cases.
    Print ISSN: 1024-123X
    Electronic ISSN: 1563-5147
    Topics: Mathematics , Technology
    Published by Hindawi
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  • 3
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    Sliding Mode Control for Mass Moment Aerospace Vehicles Using Dynamic Inversion Approach (2013)
    Hindawi
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    Publication Date: 2013-10-29
    Description: The moving mass actuation technique offers significant advantages over conventional aerodynamic control surfaces and reaction control systems, because the actuators are contained entirely within the airframe geometrical envelope. Modeling, control, and simulation of Mass Moment Aerospace Vehicles (MMAV) utilizing moving mass actuators are discussed. Dynamics of the MMAV are separated into two parts on the basis of the two time-scale separation theory: the dynamics of fast state and the dynamics of slow state. And then, in order to restrain the system chattering and keep the track performance of the system by considering aerodynamic parameter perturbation, the flight control system is designed for the two subsystems, respectively, utilizing fuzzy sliding mode control approach. The simulation results describe the effectiveness of the proposed autopilot design approach. Meanwhile, the chattering phenomenon that frequently appears in the conventional variable structure systems is also eliminated without deteriorating the system robustness.
    Print ISSN: 1024-123X
    Electronic ISSN: 1563-5147
    Topics: Mathematics , Technology
    Published by Hindawi
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  • 4
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    Substitution Pattern Reverses the Fluorescence Response of Coumarin Glycoligands upon Coordination with Silver (I) (2014)
    Nature Publishing Group (NPG)
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    Publication Date: 2014-03-04
    Description: Development of sugar-based fluorescence (FL) chemo-probes is of much interest since sugars are biocompatible, water-soluble and structurally rigid natural starting materials. We report here that fluorescent glycoligands with two triazolyl coumarin moieties installed onto the different positions of an identical glucosyl nucleus exert completely reversed optical response to a metal ion. C3,4-, C2,3- and C4,6-di-substituted coumarin glucosides synthesized by a click reaction similarly showed a selective FL variation in the presence of silver (I) among a range of metal cations in an aqueous solution. However, the variation was determined to be converse: the FL of the C3,4-ligand was quenched whereas that of the C2,3/C4,6-ligand tangibly enhanced. FL and NMR titrations suggested that this divergence was due to the distinct complexation modes of the conformationally constrained ligands with the ion. The optimal motifs of the ligand-ion complexation were predicted by a computational simulation. Finally, the C2,3-ligand was determined to be of low cytotoxicity and applicable in the FL imaging of silver ions internalized by live cells. Scientific Reports 4 doi: 10.1038/srep04252
    Electronic ISSN: 2045-2322
    Topics: Natural Sciences in General
    Published by Nature Publishing Group (NPG)
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  • 5
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    Capturing intercellular sugar-mediated ligand-receptor recognitions via a simple yet highly biospecific interfacial system (2013)
    Nature Publishing Group (NPG)
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    Publication Date: 2013-07-30
    Description: Intercellular ligand-receptor recognitions are crucial natural interactions that initiate a number of biological and pathological events. We present here the simple construction of a unique class of biomimetic interfaces based on a graphene-mediated self-assembly of glycosyl anthraquinones to a screen-printed electrode for the detection of transmembrane glycoprotein receptors expressed on a hepatoma cell line. We show that an electroactive interface confined with densely clustered galactosyl ligands is able to ingeniously recognize the asialoglycoprotein receptors on live Hep-G2 cells employing simple electrochemical techniques. The only facility used is a personal laptop in connection with a cheap and portable electrochemical workstation. Scientific Reports 3 doi: 10.1038/srep02293
    Electronic ISSN: 2045-2322
    Topics: Natural Sciences in General
    Published by Nature Publishing Group (NPG)
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  • 6
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    Iodine isotopes species fingerprinting environmental conditions in surface water along the northeastern Atlantic Ocean (2013)
    Nature Publishing Group (NPG)
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    Publication Date: 2013-11-29
    Description: Concentrations and species of iodine isotopes (127I and 129I) provide vital information about iodine geochemistry, environmental conditions and water masses exchange in oceans. Despite extensive investigations of anthropogenic 129I in the Arctic Ocean and the Nordic Seas, concentrations of the isotope in the Atlantic Ocean are, however, still unknown. We here present first data on 129I and 127I, and their species (iodide and iodate) in surface water transect along the northeastern Atlantic between 30° and 50°N. The results show iodate as the predominant species in the analyzed marine waters for both 127I and 129I. Despite the rather constant ratios of 127I−/127IO3−, the 129I−/129IO3− values reveal variations that apparently response to sources, environmental conditions and residence time. These findings provide a new tracer approach that will strongly enhance the application of anthropogenic 129I in ocean environments and impact on climate at the ocean boundary layer. Scientific Reports 3 doi: 10.1038/srep02685
    Electronic ISSN: 2045-2322
    Topics: Natural Sciences in General
    Published by Nature Publishing Group (NPG)
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  • 7
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    Research on adaptability of unbalanced three-phase pv after asynchronous networking (2018)
    Institute of Physics (IOP)
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    Publication Date: 2018-10-12
    Description: After the asynchronous network of Yunnan Power Grid and China Southern Power Grid, the characteristics of small capacity and poor anti-disturbance capability of Yunnan Power Grid are highlighted. Changes in the power grid environment make the problem of three-phase voltage imbalance more likely to occur and may deteriorate. This paper studies the ability of photovoltaic three-phase unbalanced adaptability after asynchronous networking. A double-synchronized reference coordinate model for PV in the three-phase unbalanced condition was established. The influence of the voltage negative-sequence component of the grid on the DC voltage, output current and power of the inverter was studied. A scheme for suppressing oscillation by adding a notch filter is proposed. In Matlab/Simulink, the whole process simulation of wind turbine adaptability under three-phase unbalanced change is realized. The simulation results verify the correctness of the theoretical analysis and the effectiveness ...
    Print ISSN: 1755-1307
    Electronic ISSN: 1755-1315
    Topics: Geography , Geosciences , Physics
    Published by Institute of Physics (IOP)
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  • 8
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    Delivery of inhibitor of growth 4 (ING4) gene significantly inhibits proliferation and invasion and promotes apoptosis of human osteosarcoma cells (2014)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2014-12-10
    Description: Growing evidence has suggested that inhibitor of growth 4 (ING4), a novel member of ING family proteins, plays a critical role in the development and progression of different tumors via multiple pathways. However, the function of ING4 in human osteosarcoma remains unclear. To understand its potential roles and mechanisms in inhibiting osteosarcoma, we constructed an expression vector pEGFP-ING4 and transfected the human osteosarcoma cells using this vector. We then studied the effects of over-expressed ING4 in the transfected cells on the proliferation, apoptosis and invasion of the osteosarcoma cells. The up-regulation of ING4 in the osteosarcoma cells, arising from the stable pEGFP-ING4 gene transfection, was found to significantly inhibit the cell proliferation by the cell cycle alteration with S phase reduction and G0/G1 phase arrest, induce cell apoptosis via the activation of the mitochondria pathway, and suppress cell invasion through the down-regulation of the matrix metalloproteinase 2 (MMP-2) and MMP-9 expression. In addition, increased ING4 level evoked the blockade of NF-κB signaling pathway and down-regulation of its target proteins. Our work suggests that ING4 can suppress osteosarcoma progression through signaling pathways such as mitochondria pathway and NF-κB signaling pathway and ING4 gene therapy is a promising approach to treating osteosarcoma. Scientific Reports 4 doi: 10.1038/srep07380
    Electronic ISSN: 2045-2322
    Topics: Natural Sciences in General
    Published by Nature Publishing Group (NPG)
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  • 9
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    A ‘Clicked’ Tetrameric Hydroxamic Acid Glycopeptidomimetic Antagonizes Sugar-Lectin Interactions On The Cellular Level (2014)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2014-07-02
    Description: A tetrameric N-acetyl galactosaminyl (GalNAc) peptidomimetic was constructed by N-acetylation of repeating proline-based hydroxamic acid units, followed by a convergent ‘click chemistry’ coupling. This novel glycopeptidomimetic was determined to effectively antagonize the interaction between a transmembrane hepatic lectin and GalNAc on the cellular level. Scientific Reports 4 doi: 10.1038/srep05513
    Electronic ISSN: 2045-2322
    Topics: Natural Sciences in General
    Published by Nature Publishing Group (NPG)
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  • 10
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    An Algorithm for Identifying the Isomorphism of Planar Multiple Joint and Gear Train Kinematic Chains (2016)
    Hindawi
    Details
    Publication Date: 2016-04-01
    Description: Isomorphism identification of kinematic chains is one of the most important and challenging mathematical problems in the field of mechanism structure synthesis. In this paper, a new algorithm to identify the isomorphism of planar multiple joint and gear train kinematic chains has been presented. Firstly, the topological model (TM) and the corresponding weighted adjacency matrix (WAM) are introduced to describe the two types of kinematic chains, respectively. Then, the equivalent circuit model (ECM) of TM is established and solved by using circuit analysis method. The solved node voltage sequence (NVS) is used to determine the correspondence of vertices in two isomorphism identification kinematic chains, so an algorithm to identify two specific types of isomorphic kinematic chains has been obtained. Lastly, some typical examples are carried out to prove that it is an accurate, efficient, and easy mathematical algorithm to be realized by computer.
    Print ISSN: 1024-123X
    Electronic ISSN: 1563-5147
    Topics: Mathematics , Technology
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