In:
Journal of Atherosclerosis Prevention and Treatment, Hellenic Atherosclerosis Society, ( 2020-05-03), p. 39-47
Abstract:
Aim: The sex-specific effect of lipid-related biomarkers on 10-year first fatal/non fatal cardiovascular disease (CVD) incidence was evaluated. Material and Methods: ATTICA study was conducted during 2001-2012. N=1,514 men and n=1,528 women ( 〉 18 years) from greater Athens area, Greece were recruited. Follow-up (2011-2012) was achieved in n=2,020 participants.Baseline lipid profile was measured. In particular, total cholesterol (TC), high density lipoprotein cholesterol (HDL-C) and triglycerides (TGL), apolipoprotein B100 and A1 (ApoB100 and ApoA1) were measured. Low density lipoprotein cholesterol (LDL-C) was assessed through the Friedewald formula. Results: Overall CVD event was 15.5% (n=317) (19.7% in men and 11.7% in women, p 〈 0.001). HDL-C and TGL were independently associated with CVD in women; per 10mg/dL HDL-C increase, Hazard Ratio (HR)=0.73,95% Confidence Interval (95%CI)(0.53, 1.00) and per 10mg/dLTGL increase, HR=1.10,95%CI(1.00, 1.21). ApoA1 (per 10mg/dL increase, HR=0.90,95%CI(0.81, 0.99)) was inversely associated with CVD in women while a positive association with apoB100 was observed only in men (per 10mg/dL increase, HR=1.10,95%CI(1.00, 1.21)). Conclusions: Beyond the common cholesterol-adjusted risk scores, reclassifying total CVD risk according to other lipid markers may contribute to early CVD prevention.
Type of Medium:
Online Resource
ISSN:
2654-0843
DOI:
10.53590/japt.02.1009
Language:
Unknown
Publisher:
Hellenic Atherosclerosis Society
Publication Date:
2020
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