In:
Journal of Atherosclerosis Prevention and Treatment, Hellenic Atherosclerosis Society, ( 2020-05-03), p. 67-75
Abstract:
Both the innate and adaptive arms of the immune system partake in various steps of atherogenesis. Recent studies have unraveled proatherogenic properties to clonal hematopoiesis of indeterminate potential (CHIP). Krüppel-like factors (KLFs) are transcription factors regulating pathways that confer atheroresistant and anti-inflammatory effects. Pharmaceutical targeting of inflammatory cascades could be beneficial in battling atheromatosis. Statins, aspirin, and other anti-platelet medication have off-target immune-modulatory effects. Canakinumab, a monoclonal antibody targeting IL-1β significantly reduces major adverse cardiovascular events. Nevertheless, according to the CANTOS study this does come with an increased risk of sepsis. As shown in the LoDoCo and COLCOT trials, low-dose colchicine also exerts substantial cardiovascular protection without predisposing to infections. Targeting other pathways has yet to provide an evidence of cardiovascular benefit.
Type of Medium:
Online Resource
ISSN:
2654-0843
DOI:
10.53590/japt.02.1012
Language:
Unknown
Publisher:
Hellenic Atherosclerosis Society
Publication Date:
2020
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