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  • Hanoi Medical University  (3)
  • 1
    Online Resource
    Online Resource
    Tác dụng hạ glucose máu của giảo cổ lam quả dẹt trên chuột nhắt đái tháo đường typ 2
    Hanoi Medical University ; 2022
    In:  Tạp chí Nghiên cứu Y học Vol. 156, No. 8 ( 2022-08-31), p. 157-163
    Details
    In: Tạp chí Nghiên cứu Y học, Hanoi Medical University, Vol. 156, No. 8 ( 2022-08-31), p. 157-163
    Abstract: Giảo cổ lam là một cây thuốc quý, có nhiều tác dụng dược lý đã được công nhận, bao gồm tác dụng hạ glucose máu. Giảo cổ lam có rất nhiều loài khác nhau, ở Việt Nam hiện có 6 loài đã được phát hiện, trong đó Gynostemma compressum X.X. Chen & D.R. Liang (Giảo cổ lam quả dẹt) vẫn chưa được nghiên cứu. Đề tài nhằm đánh giá tác dụng hạ glucose máu của Giảo cổ lam quả dẹt trên chuột nhắt đái tháo đường typ 2, được thực hiện trên chuột nhắt đái tháo đường typ 2 gây bởi chế độ ăn béo 8 tuần kết hợp STZ. Các thuốc nghiên cứu gồm có: STZ tiêm màng bụng liều 100mg/kg thể trọng, uống gliclazid 80mg/kg thể trọng, Giảo cổ lam quả dẹt 0,96g/kg/ngày và 2,88g/kg/ngày uống liên tục 2 tuần. Giảo cổ lam quả dẹt cả 2 liều có tác dụng hạ glucose máu và giảm tổn thương cấu trúc gan, tụy trên chuột đái tháo đường sau 2 tuần uống thuốc.
    Type of Medium: Online Resource
    ISSN: 2354-080X , 2354-080X
    URL: Issue
    URL: Article
    DOI: 10.52852/tcncyh.v156i8
    DOI: 10.52852/tcncyh.v156i8.927
    Language: Unknown
    Publisher: Hanoi Medical University
    Publication Date: 2022
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    Online Resource
  • 2
    Online Resource
    Online Resource
    Acute and sub-chronic oral toxicities of DA.AMLODEPON HVD hard capsule in experimental animals
    Hanoi Medical University ; 2021
    In:  Tạp chí Nghiên cứu Y học Vol. 148, No. 12 ( 2021-12-31), p. 58-67
    Details
    In: Tạp chí Nghiên cứu Y học, Hanoi Medical University, Vol. 148, No. 12 ( 2021-12-31), p. 58-67
    Abstract: Assessment of toxicities of DA.AMLODEPON HVD hard capsule on experimental animals. The acute toxicity of DA.AMLODEPON HVD was assessed on Swiss mice according to World Health Organization Guidance, and LD50 determination according to the method of Litchfield – Wilcoxon. The sub-chronic toxicity study of DA.AMLODEPON HVD at two doses (0.42 g/kg/day and 1.26g/kg/day) was conducted in rats for four consecutive weeks. After administration, general conditions and the body weight of rats were evaluated. Blood samples were collected for analyzing serum parameters before treatment (T0), second week (T1), and fourth week (T2). Histopathological analysis of livers and kidneys was observed at the end of the experiment. The results revealed that mice were taken up to a maximum dose of 39.15 g/kg with no symptoms of acute toxicity, LD50 of DA.AMLODEPON HVD has not been determined. The sub-chronic toxicity study at two doses did not change the body weight of rats, general conditions. The parameters for structures and functions of livers and kidneys and microscopic of the livers and kidneys are in a normal range during the study period.
    Type of Medium: Online Resource
    ISSN: 2354-080X , 2354-080X
    URL: Issue
    URL: Article
    DOI: 10.52852/tcncyh.v148i12
    DOI: 10.52852/tcncyh.v148i12.432
    Language: Unknown
    Publisher: Hanoi Medical University
    Publication Date: 2021
    Location Call Number Limitation Availability
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    Online Resource
  • 3
    Online Resource
    Online Resource
    The study of acute and subchronic toxicities of Da Dai Trang HVD capsules in experimental animals
    Hanoi Medical University ; 2021
    In:  Tạp chí Nghiên cứu Y học Vol. 148, No. 12 ( 2021-12-31), p. 7-15
    Details
    In: Tạp chí Nghiên cứu Y học, Hanoi Medical University, Vol. 148, No. 12 ( 2021-12-31), p. 7-15
    Abstract: The purpose of this research is to evaluate the acute and subchronic toxicities of DA DAI TRANG HVD capsules through oral administration in experimental animals. The acute toxicity was determined by the method of Litchfield Wilcoxon in Swiss mice. The subchronic toxicity was evaluated by the recommendation of WHO and OECD in Wistar rats with oral doses of 1.44 g/kg/day (equal to recommended human dose) and 4.32 g/kg/day (3 times as high as recommended human dose) in 4 consecutive weeks. As a result, DA DAI TRANG HVD capsules at the highest dose used for mice (99.9 g materials/kg) did not express acute toxicity in mice. In term of the subchonic toxicity test, DA DAI TRANG HVD had no deleterious effect on hematological parameters, hepato-renal functions, macroscopic and microscopic images of livers and kidneys of rats. In conclusion, DA DAI TRANG HVD capsules did not produce the acute and subchronic toxicities in Swiss mice and Wistar rats.
    Type of Medium: Online Resource
    ISSN: 2354-080X , 2354-080X
    URL: Issue
    URL: Article
    DOI: 10.52852/tcncyh.v148i12
    DOI: 10.52852/tcncyh.v148i12.773
    Language: Unknown
    Publisher: Hanoi Medical University
    Publication Date: 2021
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
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