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  • Georg Thieme Verlag KG  (5)
  • 1
    Online Resource
    Online Resource
    Erratum to: Aberrant DNA Methylation in Bladder Cancer among Saudi Arabia Population
    Georg Thieme Verlag KG ; 2022
    In:  Journal of Health and Allied Sciences NU Vol. 12, No. 02 ( 2022-05), p. 221-221
    Details
    In: Journal of Health and Allied Sciences NU, Georg Thieme Verlag KG, Vol. 12, No. 02 ( 2022-05), p. 221-221
    Type of Medium: Online Resource
    ISSN: 2582-4287 , 2582-4953
    URL: Article
    DOI: 10.1055/s-0042-1742782
    Language: English
    Publisher: Georg Thieme Verlag KG
    Publication Date: 2022
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  • 2
    Online Resource
    Online Resource
    Aberrant DNA Methylation in Bladder Cancer among Saudi Arabia Population
    Georg Thieme Verlag KG ; 2021
    In:  Journal of Health and Allied Sciences NU Vol. 11, No. 03 ( 2021-09), p. 164-169
    Details
    In: Journal of Health and Allied Sciences NU, Georg Thieme Verlag KG, Vol. 11, No. 03 ( 2021-09), p. 164-169
    Abstract: Tumor biomarkers developed based on the aberrant deoxyribonucleic acid (DNA) methylation patterns in bladder cancer (BC) hold great promise due to their stability, specificity, and known associations with the disease. No study has investigated DNA methylation patterns in BC patients from Saudi population. We analyzed DNA methylation levels of 48 tumor suppressor genes loci in 24 bladder tissues (19 BC and 5 control samples) using Human Tumour Suppressor Genes EpiTect Methyl II Complete PCR Array (Qiagen, Hilden, Germany). We identified significant difference in DNA hypermethylation levels at E2F1, ERBB2, HIC1, OPCML, SFN, SFRP1, SFRP2, SPARC, and TERT gene loci between controls and cancerous samples. SCGB3A1 was differentially methylated in nonmuscle invasive versus muscle invasive BC samples. Results suggest that these aberrant DNA methylation patterns in BC are disease and population specific and can be developed as distinct DNA methylation-based biomarkers for BC detection.
    Type of Medium: Online Resource
    ISSN: 2582-4287 , 2582-4953
    URL: Article
    DOI: 10.1055/s-0041-1726685
    Language: English
    Publisher: Georg Thieme Verlag KG
    Publication Date: 2021
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  • 3
    Online Resource
    Online Resource
    Immunomodulatory Effects of Vitamin D and Vitamin C to Improve Immunity in COVID-19 Patients
    Georg Thieme Verlag KG ; 2022
    In:  Journal of Health and Allied Sciences NU Vol. 12, No. 01 ( 2022-01), p. 1-6
    Details
    In: Journal of Health and Allied Sciences NU, Georg Thieme Verlag KG, Vol. 12, No. 01 ( 2022-01), p. 1-6
    Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS-COV2) infection causes life-threatening respiratory illness, which has caused significant mortality and morbidity around the globe. Coronavirus disease 2019 (COVID-19) causes mild respiratory illness in most infected individuals; however, in some patients it may progress to sepsis, acute respiratory distress syndrome (ARDS), cytokine release syndrome (CRS), and multiorgan dysfunction (MODS), which results in intensive care unit (ICU) admissions and increased fatalities. Recent evidence shows that most of these comorbidities associated with COVID-19 infection are associated with dysregulation of the host immune response. Vitamins C and D have been shown to regulate immune response by decreasing the proinflammatory cytokine release from immune cells and inducing proliferation of other immune cells to robustly fight infection. This review critically evaluates the current literature on vitamins C and D in modulating an immune response in different diseases and their potential therapeutic effects in preventing complications in COVID-19 infection.
    Type of Medium: Online Resource
    ISSN: 2582-4287 , 2582-4953
    URL: Article
    DOI: 10.1055/s-0041-1730084
    Language: English
    Publisher: Georg Thieme Verlag KG
    Publication Date: 2022
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  • 4
    Online Resource
    Online Resource
    3D Models as an Adjunct for Models in Studying Alzheimer's Disease
    Georg Thieme Verlag KG ; 2022
    In:  Journal of Health and Allied Sciences NU Vol. 12, No. 02 ( 2022-05), p. 179-185
    Details
    In: Journal of Health and Allied Sciences NU, Georg Thieme Verlag KG, Vol. 12, No. 02 ( 2022-05), p. 179-185
    Abstract: Alzheimer's disease (AD) is one of the most common causes of dementia. Disease progression is marked by cognitive decline and memory impairment due to neurodegenerative processes in the brain stemming from amyloid-β (Aβ) deposition and formation of neurofibrillary tangles. Pathogenesis in AD is dependent on two main neurological processes: formation of intracellular neurofibrillary tangles (NFTs) composed of hyperphosphorylated tau protein and deposition of extracellular senile Aβ peptides. Given the nature of the disease, the pathology and progression of AD in vivo in humans have been difficult to study in vivo. To this degree, models can help to study the disease pathogenesis, biochemistry, immunological functions, genetics, and potential pharmacotherapy. While animal and two-dimensional (2D) cell culture models have facilitated significant progress in studying the disease, more recent application of novel three-dimensional (3D) culture models has exhibited several advantages. Herein, we describe a brief background of AD, and how current animal, 2D, and 3D models facilitate the study of this disease and associated therapeutics.
    Type of Medium: Online Resource
    ISSN: 2582-4287 , 2582-4953
    URL: Article
    DOI: 10.1055/s-0041-1731864
    Language: English
    Publisher: Georg Thieme Verlag KG
    Publication Date: 2022
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  • 5
    Online Resource
    Online Resource
    NET-Mediated Pathogenesis of COVID-19: The Role of NETs in Hepatic Manifestations
    Georg Thieme Verlag KG ; 2022
    In:  Journal of Health and Allied Sciences NU Vol. 12, No. 03 ( 2022-07), p. 235-242
    Details
    In: Journal of Health and Allied Sciences NU, Georg Thieme Verlag KG, Vol. 12, No. 03 ( 2022-07), p. 235-242
    Abstract: Some coronavirus disease-2019 (COVID-19) patients exhibit multi-organ failure, which often includes the liver. Indeed, liver disease appears to be an emerging feature of COVID-19 infections. However, the exact mechanism behind this remains unknown. Neutrophil extracellular traps (NETs) have increasingly been attributed as major contributors to various liver pathologies, including sepsis, ischemic-reperfusion (I/R) injury, and portal hypertension in the setting of chronic liver disease. Although vital in normal immunity, excessive NET formation can drive inflammation, particularly of the endothelium. Collectively, we propose that NETs observed to be elevated in severe COVID-19 infection play principal roles in liver injury in addition to acute lung injury. Herein, we discuss the potential mechanisms underlying COVID-induced liver injury including cytopathic effects from direct liver infection, systemic inflammatory response syndrome, and hypoxic injury, encompassing I/R injury and coagulopathy. Further research is required to further elucidate the role of NETs in COVID. This holds potential therapeutic significance, as inhibition of NETosis could alleviate the symptoms of acute respiratory distress syndrome and liver injury, as well as other organs.
    Type of Medium: Online Resource
    ISSN: 2582-4287 , 2582-4953
    URL: Article
    DOI: 10.1055/s-0041-1741418
    Language: English
    Publisher: Georg Thieme Verlag KG
    Publication Date: 2022
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