GLORIA

GEOMAR Library Ocean Research Information Access

X

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Online Resource
    Online Resource
    Neue amerikanische Leitlinien zur Hypertonie: neue Konsequenzen für uns?
    Georg Thieme Verlag KG ; 2018
    In:  DMW - Deutsche Medizinische Wochenschrift Vol. 143, No. 12 ( 2018-06), p. 907-911
    Details
    In: DMW - Deutsche Medizinische Wochenschrift, Georg Thieme Verlag KG, Vol. 143, No. 12 ( 2018-06), p. 907-911
    Abstract: Following the publication of the new US guidelines, especially the new classifications of hypertension and the general reduction in treatment targets were discussed worldwide. Applying the US guidelines to a recent German cohort study would in practice lead to a significant increase in the diagnosis of “hypertension” in untreated patients. The number of under-adjusted patients would also increase sharply, increasing more than those predicted in the US Guidelines. Affected by an intensified antihypertensive therapy would be particularly elderly patients, in which adverse drug reactions but also occur more frequently. It seems doubtful whether the massive increase in the diagnosis “hypertension” can improve the supply situation: the opposite effect of avoiding therapists and patients could occur. Determining the individual risk with suitable, evaluated instruments certainly makes sense to treat more targeted patients. More important than new blood pressure limits is a more accurate classification of blood pressure. Repeated self-measurements and ambulatory blood pressure measurement lead to a better selection of patients benefiting from a therapy.
    Type of Medium: Online Resource
    ISSN: 0012-0472 , 1439-4413
    URL: Article
    DOI: 10.1055/a-0593-0310
    RVK:
    XA 39100
    RVK:
    XA 10000
    Language: German
    Publisher: Georg Thieme Verlag KG
    Publication Date: 2018
    detail.hit.zdb_id: 2035474-5
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 2
    Online Resource
    Online Resource
    ELITE-Studie – Ernährung, Lebensstil und individuelle Information zur Verhinderung von Schlaganfall, Demenz und Herzinfarkt – Studiendesign und kardiovaskuläre Aufnahmedate
    Georg Thieme Verlag KG ; 2019
    In:  DMW - Deutsche Medizinische Wochenschrift Vol. 144, No. 06 ( 2019-03), p. e42-e50
    Details
    In: DMW - Deutsche Medizinische Wochenschrift, Georg Thieme Verlag KG, Vol. 144, No. 06 ( 2019-03), p. e42-e50
    Abstract: Einleitung Zur Prävention kardiovaskulärer Risikofaktoren (RF) existieren zahlreiche Empfehlungen von Fachgesellschaften, die sich auf die persönliche Lebensweise von Menschen beziehen (z. B. Ernährung/Diät, körperliche Aktivität, Stressabbau etc.). Die Umsetzung dieser Empfehlungen ist bislang mangelhaft. In der ELITE-Studie sollen in der Region Oldenburger Münsterland prospektiv Daten zu RF, Ernährungsverhalten, körperlicher Aktivität und Lebensqualität erhoben und durch individuelle Information verbessert werden. Gründe für fehlende Umsetzung von Präventionsmaßnahmen sollen erkannt werden. Methoden Die Studie wird als interventionelle Kohorten-Untersuchung durchgeführt (DRKS-Nr.: 00 006 813; Ethikvotum Universität Göttingen). Bis zu 5000 Personen (mit oder ohne Vorerkrankungen) sollten eingeschlossen werden. Alle Teilnehmer erhalten einen computergenerierten Report ihres persönlichen Risikoprofils mit hieraus resultierenden ausführlichen Empfehlungen, die sich an den aktuellen Leitlinien orientieren. Ergänzend wird empfohlen, den Hausarzt aufzusuchen, um die Befunde zu besprechen und ggf. diagnostische oder therapeutische Maßnahmen einzuleiten. Im Jahresabstand erfolgen über bis zu 5 Jahre Follow-Up-Untersuchungen. Ergebnisse Bis zum 31.12.2017 wurden 4602 Teilnehmer (mittleres Alter 51,5 (± 15,7) Jahre; 53,7 % weiblich) aufgenommen. Übergewichtig sind 39 % der Teilnehmer, adipös 20,4 %. Häufigster anamnestischer RF ist Bluthochdruck (31,4 %), mittlerer Blutdruck 138,4 ± 16,6/83,0 ± 9,9 mmHg. 2165 (47,0 %) Teilnehmer weisen hypertone Blutdruckwerte auf. Zweithäufigster anamnestischer RF sind Fettstoffwechselstörungen (16,6 %). Schlussfolgerung Die Häufigkeit von Teilnehmern mit mindestens einem anamnestisch angegebenen kardiovaskulären RF ist sehr hoch (49,5 %; 16,6 % mehrere RF). Die Häufigkeit von RF entspricht anderen epidemiologischen Daten in Deutschland, sodass das ELITE-Kollektiv einen guten Vergleich mit anderen Erhebungen zulässt.
    Type of Medium: Online Resource
    ISSN: 0012-0472 , 1439-4413
    URL: Article
    DOI: 10.1055/a-0714-3835
    RVK:
    XA 39100
    RVK:
    XA 10000
    Language: German
    Publisher: Georg Thieme Verlag KG
    Publication Date: 2019
    detail.hit.zdb_id: 2035474-5
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 3
    Online Resource
    Online Resource
    Gastric NET Subtypes: Do We Need An Additional One?
    Georg Thieme Verlag KG ; 2021
    In:  Zeitschrift für Gastroenterologie Vol. 59, No. 03 ( 2021-03), p. 255-258
    Details
    In: Zeitschrift für Gastroenterologie, Georg Thieme Verlag KG, Vol. 59, No. 03 ( 2021-03), p. 255-258
    Abstract: Depending on etiology, prognosis and malignant potential, recent S2k guideline differentiates gastric neuroendocrine tumors (gNET) in 4 types with different treatment implications. We report on a 55-year-old patient with the accidental finding of a 15 mm gNET. Apart from a prolonged use of proton pump inhibitors (PPI) for 20 years as a treatment for gastroesophageal reflux disease, there were no other associations or risk factors for gNETs. Formally, this patient would have been classified as a type III gNET, implicating gastric surgery. From a pathophysiological point of view, however, the assumed prolonged gastrin hypersecretion would have justified an assignment as a type I gNET. The gNET was resected by ESD, but histology showed an R1 situation. After cessation of PPIs, there is no recurrence so far. Besides, the initially documented numerous and large gland polyps showed an impressive regression only a few weeks after cessation of PPI. This case points to a probably underestimated gap in the present gNET classification. On the basis of present literature, the therapeutic dilemma of PPI-associated gNETs is discussed. A new assignment of PPI associated gNETs as type Ib could help to overcome this dilemma.
    Type of Medium: Online Resource
    ISSN: 0044-2771 , 1439-7803
    URL: Article
    DOI: 10.1055/a-1348-2727
    RVK:
    XA 10000
    Language: English
    Publisher: Georg Thieme Verlag KG
    Publication Date: 2021
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 4
    Online Resource
    Online Resource
    Interleukin-4 differentially regulates osteoprotegerin expression and induces calcification in vascular smooth muscle cells
    Georg Thieme Verlag KG ; 2006
    In:  Thrombosis and Haemostasis Vol. 95, No. 04 ( 2006), p. 708-714
    Details
    In: Thrombosis and Haemostasis, Georg Thieme Verlag KG, Vol. 95, No. 04 ( 2006), p. 708-714
    Abstract: Vascular calcification is characterized by cellular transdifferentiation and expression of bone-related matrix proteins that result in the presence of bone-like structures in the vascular wall. Interleukin (IL)-4, a pleiotropic cytokine, and osteoprotegerin (OPG), an essential regulator of osteoclast biology, have both been linked to vascular disease. Here, we assessed the role of IL-4 and OPG in vascular calcification in vitro. IL-4 induced OPG mRNA levels and protein secretion by 5-fold in a dose-and time-dependent fashion in human coronary artery smooth muscle cells (CASMC). Activation of the transcription factor STAT6 preceded IL-4-induced OPG expression, and blockade of IL-4-induced STAT6 activation by the phospholipase C inhibitor D609 decreased OPG expression. Long-term exposure of IL-4 for 4 weeks resulted in transformation of CASMC towards an osteoblastic phenotype, based on the expression of the transcription factor Cbfa1 and increased mineral deposition. Notably, calcification of CASMC was inhibited by gene silencing of Cbfa1. During osteogenic transformation, IL-4 down-regulated OPG production in CASMC. IL-4 has differential effects in CASMC: While short-term exposure enhances OPG production through a STAT6-dependent mechanism, long-term exposure causes Cbfa1-dependent osteogenic transformation anda decreased production of OPG, an inhibitor of bone resorption.
    Type of Medium: Online Resource
    ISSN: 0340-6245 , 2567-689X
    URL: Article
    DOI: 10.1160/TH05-12-0800
    Language: English
    Publisher: Georg Thieme Verlag KG
    Publication Date: 2006
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 5
    Online Resource
    Online Resource
    Bifunctional Bisamphiphilic Transmembrane Building Blocks for Artificial ­Signal Transduction
    Georg Thieme Verlag KG ; 2008
    In:  Synthesis Vol. 2008, No. 14 ( 2008-7), p. 2247-2256
    Details
    In: Synthesis, Georg Thieme Verlag KG, Vol. 2008, No. 14 ( 2008-7), p. 2247-2256
    Type of Medium: Online Resource
    ISSN: 0039-7881 , 1437-210X
    URL: Article
    DOI: 10.1055/s-2008-1067155
    RVK:
    VA 7380
    Language: English
    Publisher: Georg Thieme Verlag KG
    Publication Date: 2008
    detail.hit.zdb_id: 204080-3
    detail.hit.zdb_id: 2033062-5
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...