GLORIA

GEOMAR Library Ocean Research Information Access

X

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Online Resource
    Online Resource
    Invasive Lidinfektionen durch β-hämolysierende Streptokokken der Serogruppe A
    Georg Thieme Verlag KG ; 2020
    In:  Klinische Monatsblätter für Augenheilkunde Vol. 237, No. 02 ( 2020-02), p. 180-184
    Details
    In: Klinische Monatsblätter für Augenheilkunde, Georg Thieme Verlag KG, Vol. 237, No. 02 ( 2020-02), p. 180-184
    Abstract: Hintergrund Invasive Weichteilinfektionen durch Streptokokken sind schnell fortschreitende und potenziell lebensbedrohliche Infektionserkrankungen. Diese können auch das Augenlid betreffen. Aufgrund aggressiver Virulenzfaktoren und der Synthese von Exotoxinen kann es zu Komplikationen wie der periorbitalen nekrotisierenden Fasziitis (PONF) und dem Streptokokken-Toxic-Shock-Syndrom (STSS) kommen. Anhand von 4 Patienten mit invasiven Lidinfektionen wird das Krankheitsbild charakterisiert. Material und Methode Bei allen Patienten erfolgte eine Fotodokumentation, Bildgebung, Labor- und Abstrichdiagnostik sowie eine intravenöse antibiotische Therapie gemäß den Empfehlungen des Robert Koch-Instituts sowie des lokalen Infektiologieboards. Ergebnisse Bei allen Patienten wurde Streptococcus pyogenes im Abstrich kulturell nachgewiesen. Das Antibiogramm zeigte eine Sensibilität gegenüber den gängigen intravenösen Antibiotika. Das Zeitintervall zwischen Symptombeginn und Vorstellung in der Klinik betrug zwischen 2 Tagen und 1 Woche. Alle Patienten wiesen bei Aufnahme hohe systemische Entzündungsparameter auf: Pat. 1: CRP 259 mg/l, Leukozyten 20,1 Giga/l; Pat. 2: CRP 375 mg/l, Leukozyten 15,6 Giga/l; Pat. 3: CRP 378 mg/l, Leukozyten 38,7 Giga/l; Pat. 4: CRP 483 mg/l, Leukozyten 1,7 Giga/l; Normwerte: CRP 〈  5 mg/l, Leukozyten 4,4 – 11,3 Giga/l. Bei den Pat. 2 und 3 wurde aufgrund der rasch fortschreitenden Nekrosen im Bereich von Kutis und Subkutis und der systemischen Toxizität eine periorbitale nekrotisierende Fasziitis diagnostiziert. Die Pat. 3 und 4 erfüllten die Diagnosekriterien eines STSS. Die Pat. 2, 3 und 4 mussten, trotz unverzüglich begonnener intravenöser antibiotischer Therapie, mit einer Sepsis auf eine Intermediate Care Unit bzw. Intensivstation verlegt werden. Bei Pat. 3 erfolgte ein chirurgisches Wunddébridement während des Aufenthaltes. Dank eines interdisziplinären Managements (Augenheilkunde, Infektiologie, HNO, Innere und Intensivmedizin) konnten schlussendlich alle Patienten in deutlich gebessertem Allgemeinzustand aus unserer stationären Behandlung entlassen werden. Schlussfolgerung Invasive Streptokokkeninfektionen stellen eine Herausforderung im klinischen Alltag eines Ophthalmologen dar. Ein interdisziplinäres Management sowie ein sofortiger Beginn einer hochdosierten intravenösen antibiotischen Therapie sind für den Therapieerfolg entscheidend.
    Type of Medium: Online Resource
    ISSN: 0023-2165 , 1439-3999
    URL: Article
    DOI: 10.1055/a-0972-9835
    RVK:
    XA 10000
    Language: German
    Publisher: Georg Thieme Verlag KG
    Publication Date: 2020
    detail.hit.zdb_id: 2039754-9
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 2
    Online Resource
    Online Resource
    Beidseitige Visusminderung mit Papillenödem bei duraler arteriovenöser Fistel und Sinusvenenthrombose
    Georg Thieme Verlag KG ; 2022
    In:  Klinische Monatsblätter für Augenheilkunde Vol. 239, No. 01 ( 2022-01), p. 103-105
    Details
    In: Klinische Monatsblätter für Augenheilkunde, Georg Thieme Verlag KG, Vol. 239, No. 01 ( 2022-01), p. 103-105
    Type of Medium: Online Resource
    ISSN: 0023-2165 , 1439-3999
    URL: Article
    DOI: 10.1055/a-1327-3439
    RVK:
    XA 10000
    Language: German
    Publisher: Georg Thieme Verlag KG
    Publication Date: 2022
    detail.hit.zdb_id: 2039754-9
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 3
    Online Resource
    Online Resource
    Pigmentierte Bindehautveränderungen
    Georg Thieme Verlag KG ; 2021
    In:  Klinische Monatsblätter für Augenheilkunde Vol. 238, No. 08 ( 2021-08), p. 899-900
    Details
    In: Klinische Monatsblätter für Augenheilkunde, Georg Thieme Verlag KG, Vol. 238, No. 08 ( 2021-08), p. 899-900
    Type of Medium: Online Resource
    ISSN: 0023-2165 , 1439-3999
    URL: Article
    DOI: 10.1055/a-0839-5100
    RVK:
    XA 10000
    Language: German
    Publisher: Georg Thieme Verlag KG
    Publication Date: 2021
    detail.hit.zdb_id: 2039754-9
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 4
    Online Resource
    Online Resource
    Antibiotikaprophylaxe und empirische Antibiotikatherapie bei Primärendoprothetik und periprothetischen Gelenkinfektionen: Aktuelle Praxis und Bedarf an Therapieoptimierung
    Georg Thieme Verlag KG ; 2023
    In:  Zeitschrift für Orthopädie und Unfallchirurgie Vol. 161, No. 06 ( 2023-12), p. 654-659
    Details
    In: Zeitschrift für Orthopädie und Unfallchirurgie, Georg Thieme Verlag KG, Vol. 161, No. 06 ( 2023-12), p. 654-659
    Abstract: The aim of the present work was to survey the situation of healthcare regarding the use of prophylactic and empirical antibiotics in primary arthroplasty and treatment of periprosthetic joint infections (PJI). For this purpose, a survey was conducted at German university and occupational accident hospitals. Survey data was compared to previously published data on the antimicrobial regimes of PJI (n=81) patients (n=81) treated in our department between 2017 and 2020. A homogeneous picture emerged for the prophylactic administration of antibiotics in the context of primary arthroplasty. In 93.2% (elective) and 88.6% (fracture treatment) of the hospitals, first or second generation cephalosporins were administered perioperatively for infection prophylaxis in primary hip arthroplasty. The empirical antibiotic treatment of PJIs showed a clearly inhomogeneous therapeutic picture. Monotherapy with an aminopenicillin plus a beta-lactamase inhibitor is used most frequently (38.7%); first and second generation cephalosporins are used second most frequently as monotherapy (18.2%). In light of the global problem of antibiotic multi-resistance, clinical use of antibiotics has to be reasonable and effective. The present results highlight the further need to improve awareness and following existing guidelines in the administration of empirical antibiotic therapy in PJI.
    Type of Medium: Online Resource
    ISSN: 1864-6697 , 1864-6743
    URL: Article
    DOI: 10.1055/a-1773-1382
    Language: German
    Publisher: Georg Thieme Verlag KG
    Publication Date: 2023
    detail.hit.zdb_id: 2280747-0
    detail.hit.zdb_id: 2304338-6
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 5
    Online Resource
    Online Resource
    Association of Platelet-to-Lymphocyte Ratio and Neutrophil-to-Lymphocyte Ratio with the Risk of Thromboembolism and Mortality in Patients with Cancer
    Georg Thieme Verlag KG ; 2018
    In:  Thrombosis and Haemostasis Vol. 118, No. 11 ( 2018-11), p. 1875-1884
    Details
    In: Thrombosis and Haemostasis, Georg Thieme Verlag KG, Vol. 118, No. 11 ( 2018-11), p. 1875-1884
    Abstract: Patients with cancer are at risk of developing venous and arterial thromboembolism (VTE and ATE). Elevated platelet-to-lymphocyte (PLR) and neutrophil-to-lymphocyte ratios (NLR) have been suggested as potential biomarkers for cancer-associated chronic inflammation, VTE and mortality. We investigated the association between PLR and NLR with VTE, ATE and mortality in patients with cancer. Within a prospective cohort study, we followed-up patients with newly diagnosed or progressing cancer for objectively confirmed, symptomatic VTE, ATE and death. Fine and Gray competing-risk regression was used to model the risk of VTE and ATE. Overall survival was analysed with Kaplan–Meier estimators. From 2003 to 2013, 1,469 patients with solid cancer (median age: 61 years; 47.3% female) were recruited and followed for 2 years. Overall, 128 (8.7%) patients developed VTE, 41 (2.8%) ATE and 643 (43.8%) patients died. The sub-distribution hazard ratios (SHRs) for VTE per doubling of PLR and NLR were 1.0 (95% confidence interval [CI]: 0.8–1.3, p = 0.899) and 1.2 (1.0–1.4, p = 0.059), respectively. For ATE, the SHR per doubling of PLR and NLR were 1.0 (0.7–1.5, p = 0.940) and 1.2 (0.9–1.6, p = 0.191), respectively. A higher PLR (hazard ratio [HR] per doubling = 1.5, 1.4–1.7, p  〈  0.001) and a higher NLR (HR per doubling = 1.5, 1.4–1.7, p  〈  0.001) were associated with an increased risk of mortality after adjusting for age, sex and cancer stage. There was no statistically significant association between NLR and VTE occurrence in patients with cancer. Neither PLR nor NLR were associated with the risk of ATE. Both elevated PLR and NLR were independently associated with a twofold increased risk of mortality.
    Type of Medium: Online Resource
    ISSN: 0340-6245 , 2567-689X
    URL: Article
    DOI: 10.1055/s-0038-1673401
    Language: English
    Publisher: Georg Thieme Verlag KG
    Publication Date: 2018
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 6
    Online Resource
    Online Resource
    Imaging the elastic modulus of human platelets during thrombininduced activation using scanning ion conductance microscopy
    Georg Thieme Verlag KG ; 2015
    In:  Thrombosis and Haemostasis Vol. 113, No. 02 ( 2015-03), p. 305-311
    Details
    In: Thrombosis and Haemostasis, Georg Thieme Verlag KG, Vol. 113, No. 02 ( 2015-03), p. 305-311
    Abstract: Platelet activation plays a critical role in haemostasis and thrombosis. It is well-known that platelets generate contractile forces during activation. However, their mechanical material properties have rarely been investigated. Here, we use scanning ion conductance microscopy (SICM) to visualise morphological and mechanical properties of live human platelets at high spatial resolution. We found that their mean elastic modulus decreases during thrombin-induced activation by about a factor of two. We observed a similar softening of platelets during cytochalasin D-induced cytoskeleton depolymerisation. However, thrombin-induced temporal and spatial modulations of the elastic modulus were substantially different from cytochalasin D-mediated changes. We thereby provide new insights into the mechanics of haemostasis and establish SICM as a novel imaging platform for the ex vivo investigation of the mechanical properties of live platelets.
    Type of Medium: Online Resource
    ISSN: 0340-6245 , 2567-689X
    URL: Article
    DOI: 10.1160/TH14-05-0414
    Language: English
    Publisher: Georg Thieme Verlag KG
    Publication Date: 2015
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 7
    Online Resource
    Online Resource
    Regulation of STIM1/Orai1-dependent Ca2+ signalling in platelets
    Georg Thieme Verlag KG ; 2013
    In:  Thrombosis and Haemostasis Vol. 110, No. 11 ( 2013), p. 925-930
    Details
    In: Thrombosis and Haemostasis, Georg Thieme Verlag KG, Vol. 110, No. 11 ( 2013), p. 925-930
    Abstract: Platelet secretion and aggregation as well as thrombus formation of blood platelets critically depend on increase of cytosolic Ca2+ concentration ([Ca2+]i) mainly resulting from intracellular Ca2+ release followed by store operated Ca2+ entry (SOCE) through Ca2+ release activated channels (CRAC). SOCE is in part accomplished by the pore forming unit Orai and its regulator stromal interaction molecule (STIM). Orai1 and STIM1 transcription is stimulated by NFkB (nuclear factor kappa B). Serum- and glucocorticoid-inducible kinase 1 (SGK1) up-regulates NFkB-activity in megakaryocytes and thus Orai1- expression and SOCE in platelets. SGK1 is thus a powerful regulator of platelet Ca2+-signalling and thrombus formation and presumably participates in the regulation of platelet activation by a variety of hormones as well as clinical conditions (e.g. type 2 diabetes or metabolic syndrome) associated with platelet hyperaggregability and increased risk of thromboocclusive events. SOCE in platelets is further regulated by scaffolding protein Homer and chaperone protein cyclophilin A (CyPA). Additional potential regulators of Orai1/STIM1 and thus SOCE in platelets include AMP activated kinase (AMPK), protein kinase A (PKA), reactive oxygen species, lipid rafts, pH and mitochondrial Ca2+ buffering. Future studies are required defining the significance of those mechanisms for platelet Orai1 abundance and function, for SOCE into platelets and for platelet function in cardiovascular diseases.
    Type of Medium: Online Resource
    ISSN: 0340-6245 , 2567-689X
    URL: Article
    DOI: 10.1160/TH13-02-0176
    Language: English
    Publisher: Georg Thieme Verlag KG
    Publication Date: 2013
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 8
    Online Resource
    Online Resource
    CD44 sensitivity of platelet activation, membrane scrambling and adhesion under high arterial shear rates
    Georg Thieme Verlag KG ; 2016
    In:  Thrombosis and Haemostasis Vol. 115, No. 01 ( 2016-01), p. 99-108
    Details
    In: Thrombosis and Haemostasis, Georg Thieme Verlag KG, Vol. 115, No. 01 ( 2016-01), p. 99-108
    Abstract: CD44 is required for signalling of macrophage migration inhibitory factor (MIF), an anti-apoptotic pro-inflammatory cytokine. MIF is expressed and released from blood platelets, key players in the orchestration of occlusive vascular disease. Nothing is known about a role of CD44 in the regulation of platelet function. The present study thus explored whether CD44 modifies degranulation (P-selectin exposure), integrin activation, caspase activity, phosphatidylserine exposure on the platelet surface, platelet volume, Orai1 protein abundance and cytosolic Ca2+-activity ([Ca2+]i). Platelets from mice lacking CD44 (cd44-/- ) were compared to platelets from corresponding wild-type mice (cd44+/+ ). In resting platelets, P-selectin abundance, αllbβ3 inte-grin activation, caspase-3 activity and phosphatidylserine exposure were negligible in both genotypes and Orai1 protein abundance, [Ca2+] i, and volume were similar in cd44-/- and cd44+/+ platelets. Platelet degranulation and αllbβ3 integrin activation were significantly increased by thrombin (0.02 U/ml), collagen related peptide (CRP, 2 µg/ml and Ca2+-store depletion with thapsigargin (1 µM), effects more pronounced in cd44-/- than in cd44+/+ platelets. Thrombin (0.02 U/ml) increased platelet [Ca2+]i, caspase-3 activity, phosphatidylserine exposure and Orai1 surface abundance, effects again significantly stronger in cd44-/- than in cd44+/+ platelets. Thrombin further decreased forward scatter in cd44-/- and cd44+/+ platelets, an effect which tended to be again more pronounced in cd44-/- than in cd44+/+ platelets. Platelet adhesion and in vitro thrombus formation under high arterial shear rates (1,700 s-1) were significantly augmented in cd44-/- mice. In conclusion, genetic deficiency of CD44 augments activation, apoptosis and prothrombotic potential of platelets.
    Type of Medium: Online Resource
    ISSN: 0340-6245 , 2567-689X
    URL: Article
    DOI: 10.1160/TH14-10-0847
    Language: English
    Publisher: Georg Thieme Verlag KG
    Publication Date: 2016
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 9
    Online Resource
    Online Resource
    Oncologic Panendoscopy: Description of an Optimized Procedure Based on Our Experience
    Georg Thieme Verlag KG ; 2022
    In:  International Archives of Otorhinolaryngology Vol. 26, No. 01 ( 2022-01), p. e125-e131
    Details
    In: International Archives of Otorhinolaryngology, Georg Thieme Verlag KG, Vol. 26, No. 01 ( 2022-01), p. e125-e131
    Abstract: Introduction All patients with a new head and neck squamous cell carcinoma (HNSCC) undergo diagnostic panendoscopy as part of the screening for synchronous second primary tumors. It includes a pharyngolaryngoscopy (PLS), a tracheobronchoscopy and esophagoscopy, and a stomatoscopy. Rigid techniques are risky, with long learning curves. Objective We propose a precise description of the panendoscopy protocol. We include an optimization of the PLS technique that completes the flexible esophagoscopy when rigid esophagoscopy isn't performed. Methods The present retrospective observational study includes 122 consecutive patients with a new primary HNSCC who underwent traditional panendoscopy and the new PLS technique between January 2014 and December 2016. A two-step procedure using a Macintosh laryngoscope and a 30° telescope first exposes panoramically the larynx, the upper trachea, and the oropharynx; then, in a second step, the hypopharynx is exposed down to the upper esophageal sphincter. Broncho-esophagoscopy is performed with a rigid and flexible scope. Results In total, 6 (5%) patients presented synchronous tumors (3 in the esophagus, 2 in the oral cavity, and 1 in the larynx 1). Rigid endoscopy was complicated by 2 (1,6%) dental lesions, and had to be completed with a flexible scope in 38 (33%) cases for exposition reasons. The two-step PLS offered a wide-angle view of the larynx, upper trachea, and oro- and hypopharynx down to the sphincter of the upper esophagus. The procedure was easy, reliable, safe, repeatable, and effectively completed the flexible endoscopies. Conclusion Rigid esophagoscopy remains a difficult procedure. Two-step PLS combined with flexible broncho-esophagoscopy offers good optical control.
    Type of Medium: Online Resource
    ISSN: 1809-9777 , 1809-4864
    URL: Article
    DOI: 10.1055/s-0041-1726049
    Language: English
    Publisher: Georg Thieme Verlag KG
    Publication Date: 2022
    detail.hit.zdb_id: 2578584-9
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 10
    Online Resource
    Online Resource
    SGK1 up-regulates Orai1 expression and VSMC migration during neointima formation after arterial injury
    Georg Thieme Verlag KG ; 2017
    In:  Thrombosis and Haemostasis Vol. 117, No. 05 ( 2017), p. 1002-1005
    Details
    In: Thrombosis and Haemostasis, Georg Thieme Verlag KG, Vol. 117, No. 05 ( 2017), p. 1002-1005
    Abstract: Supplementary Material to this article is available online at www.thrombosis-online.com
    Type of Medium: Online Resource
    ISSN: 0340-6245 , 2567-689X
    URL: Article
    DOI: 10.1160/TH16-09-0690
    Language: English
    Publisher: Georg Thieme Verlag KG
    Publication Date: 2017
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...