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  • 1
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    Factor VII and Fibrinogen Levels Examined by Age, Sex, and other Atherosclerotic Risk Factors in a Japanese Population : The Jichi Medical School Cohort Study
    Georg Thieme Verlag KG ; 1997
    In:  Thrombosis and Haemostasis Vol. 77, No. 05 ( 1997), p. 0890-0893
    Details
    In: Thrombosis and Haemostasis, Georg Thieme Verlag KG, Vol. 77, No. 05 ( 1997), p. 0890-0893
    Abstract: Factor VII coagulant activity (FVIIc) and fibrinogen (Fbg) levels have been investigated as cardiovascular risk factors. We studied these two factors with stratification for age, sex and blood pressure, and the relation with other atherosclerotic risk factors in a Japanese general population. The subjects were 3,139 Japanese (1,315 males and 1,824 females) aged 30 to 89 in 1992 and 1993. A linear increase with age was observed in the levels of Fbg in both men and women, but no differences were observed between men and women in each age group. A linear increase with age was also seen in the levels of FVIIc in women, but the levels of FVIIc in men were significantly higher for the age group 40-49 years than for any other age group. The levels of FVIIc in women were significantly higher than in men at age ≥60 years. As concerning the effect of alcohol intake status, Fbg had a tendency to decrease with alcohol intake. Fbg and FVIIc levels were associated with an increase in smoking status in men, but no association was seen in women in either Fbg or FVIIc. FVIIc was positively correlated with age, body mass index, total cholesterol, triglycerides and fasting insulin level. Fbg was positively correlated with age, systolic blood pressure, diastolic blood pressure, total cholesterol, LDL-cholesterol and triglycerides in women, but Fbg had few positive correlations with risk factors in men. A comparison with previous Western studies showed that the Fbg levels of our Japanese population were lower than those of the Caucasians studied, but the present FVIIc levels were nearly the same level or slightly higher than theirs. The association of Fbg and FVIIc and with other cardiovascular risk factors in Japanese was similar to those observed in Caucasians.
    Type of Medium: Online Resource
    ISSN: 0340-6245 , 2567-689X
    URL: Article
    DOI: 10.1055/s-0038-1656073
    Language: English
    Publisher: Georg Thieme Verlag KG
    Publication Date: 1997
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  • 2
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    Marked Increase of Activated Factor VII in Uremic Patients
    Georg Thieme Verlag KG ; 1995
    In:  Thrombosis and Haemostasis Vol. 73, No. 05 ( 1995), p. 763-767
    Details
    In: Thrombosis and Haemostasis, Georg Thieme Verlag KG, Vol. 73, No. 05 ( 1995), p. 763-767
    Abstract: We investigated plasma activated factor VII (FVIIa) levels in uremic patients (nondialysis group: n = 38; dialysis group: n = 36) and healthy controls (n = 32). We also measured the plasma levels of thrombomodulin (an indicator of endothelial cell injury) and tissue factor. Plasma FVIIa showed a marked increase in the nondialysis group (mean [95% confidence interval]: 4.6 [4.1-5.1] ng/ml, p 〈 0.0001) with the progressive impairment of renal function, as indicated by the serum creatinine level, when compared with the 32 controls (2.8 [2.5-3.1] ng/ml), and was further increased in the dialysis group (6.1 [5.5-6.8] ng/ml, p 〈 0.001 vs. nondialysis group). Plasma levels of thrombomodulin and tissue factor were also higher in the nondialysis group than the control group, and were further increased in the dialysis group. Plasma tissue factor levels did not show any correlation with FVIIa or thrombomodulin in both the nondialysis and dialysis groups. Thus, circulating tissue factor appears to be released by a different mechanism from thrombomodulin and may not contribute to the direct activation of factor VII in uremic patients. On the other hand, the plasma level of thrombomodulin was positively correlated with that of FVIIa in the nondialysis group, and this correlation was independent of renal function. Thus, enhanced conversion of factor VII zymogen to FVIIa, probably related to endothelial cell injury, may be a risk factor for cardiovascular events in uremic patients.
    Type of Medium: Online Resource
    ISSN: 0340-6245 , 2567-689X
    URL: Article
    DOI: 10.1055/s-0038-1653865
    Language: English
    Publisher: Georg Thieme Verlag KG
    Publication Date: 1995
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  • 3
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    Increased Incidence of Cardiovascular Attacks in the Epicenter Just After the Hanshin-Awaji Earthquake
    Georg Thieme Verlag KG ; 1995
    In:  Thrombosis and Haemostasis Vol. 74, No. 04 ( 1995), p. 1207-1207
    Details
    In: Thrombosis and Haemostasis, Georg Thieme Verlag KG, Vol. 74, No. 04 ( 1995), p. 1207-1207
    Type of Medium: Online Resource
    ISSN: 0340-6245 , 2567-689X
    URL: Article
    DOI: 10.1055/s-0038-1649912
    Language: English
    Publisher: Georg Thieme Verlag KG
    Publication Date: 1995
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  • 4
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    High Lipoprotein (a) Levels in Chronic Hemodialysis Patients are Closely Related to the Acute Phase Reaction
    Georg Thieme Verlag KG ; 1995
    In:  Thrombosis and Haemostasis Vol. 74, No. 04 ( 1995), p. 1020-1024
    Details
    In: Thrombosis and Haemostasis, Georg Thieme Verlag KG, Vol. 74, No. 04 ( 1995), p. 1020-1024
    Abstract: To study the mechanism underlying the high lipoprotein (a) [Lp(a)] level in uremic patients on chronic hemodialysis, we investigated the levels of Lp(a), acute phase reactants (C-reactive protein and sialic acid), and interleukin-6 (IL-6) in 54 dialysis patients. The mean [95% Cl] Lp(a) level was increased in the hemodialysis patients compared with the 30 controls (30 [25-36] vs. 18 [14-23] mg/dl, p 〈 0.005). Among dialysis patients, 46% had an Lp(a) level 〉 30 mg/dl, which was significantly higher than the percentage in the control group (17%). The levels of C-reactive protein, sialic acid, and IL-6 were also increased in dialysis subjects compared with controls (200 [134-299] vs. 37 [24-58] μg/dl, p 〈 0.0001; 63 [59-66] vs. 54 [52-56] mg/dl, p 〈 0.002; and 9.2 [7.8-11] vs. 5.5 [5.0-6.1] pg/ml, p 〈 0.0005, respectively). The Lp(a) level was positively correlated with that of C-reactive protein (r = 0.415, p 〈 0.002), sialic acid (r = 0.426, p 〈 0.002), and IL-6 (r = 0.298, p 〈 0.05) in the hemodialysis patients, but not in the controls or non-dialysis uremic patients. The Lp(a) level in the dialysis patients was also positively correlated with activation markers of coagulation (thrombin-antithrombin III complex and plasmin-α2-plasmin inhibitor complex, p 〈 0.005). These results indicate that the Lp(a) level is closely related to the acute phase reaction and hypercoagulability in chronic hemodialysis patients.
    Type of Medium: Online Resource
    ISSN: 0340-6245 , 2567-689X
    URL: Article
    DOI: 10.1055/s-0038-1649872
    Language: English
    Publisher: Georg Thieme Verlag KG
    Publication Date: 1995
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  • 5
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    Fibrin D-Dimer in Thrombogenic Disorders
    Georg Thieme Verlag KG ; 2000
    In:  Seminars in Thrombosis and Hemostasis Vol. Volume 26, No. Number 01 ( 2000), p. 101-107
    Details
    In: Seminars in Thrombosis and Hemostasis, Georg Thieme Verlag KG, Vol. Volume 26, No. Number 01 ( 2000), p. 101-107
    Type of Medium: Online Resource
    ISSN: 0094-6176 , 1098-9064
    URL: Article
    DOI: 10.1055/s-2000-9811
    Language: Unknown
    Publisher: Georg Thieme Verlag KG
    Publication Date: 2000
    detail.hit.zdb_id: 2072469-X
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  • 6
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    Studies on Congenital Protein C Deficiency in Japanese: Prevalence, Genetic Analysis, and Relevance to the Onset of Arterial Occlusive Diseases
    Georg Thieme Verlag KG ; 2000
    In:  Seminars in Thrombosis and Hemostasis Vol. Volume 26, No. Number 01 ( 2000), p. 011-016
    Details
    In: Seminars in Thrombosis and Hemostasis, Georg Thieme Verlag KG, Vol. Volume 26, No. Number 01 ( 2000), p. 011-016
    Type of Medium: Online Resource
    ISSN: 0094-6176 , 1098-9064
    URL: Article
    DOI: 10.1055/s-2000-9796
    Language: Unknown
    Publisher: Georg Thieme Verlag KG
    Publication Date: 2000
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  • 7
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    Cardiovascular events occur independently of high on-aspirin platelet reactivity and residual COX-1 activity in stable cardiovascular patients
    Georg Thieme Verlag KG ; 2016
    In:  Thrombosis and Haemostasis Vol. 116, No. 08 ( 2016-02), p. 356-368
    Details
    In: Thrombosis and Haemostasis, Georg Thieme Verlag KG, Vol. 116, No. 08 ( 2016-02), p. 356-368
    Abstract: Several studies have indicated that approximately 25% of patients treated with aspirin exhibit high on-treatment platelet reactivity (HTPR), which is potentially associated with cardiovascular events (CVEs). However, this association is still controversial, since the mechanisms by which HTPR contributes to CVEs remain unclear and a no standardised definition of HTPR has been established. To determine whether HTPR is associated with CVE recurrence and what type of assay would best predict CVE recurrence, we conducted a multicentre prospective cohort study of 592 stable cardiovascular outpatients treated with aspirin monotherapy for secondary prevention. Their HTPR was determined by arachidonic acid- or collagen-induced aggregation assays using two different agonist concentrations. Residual cyclooxygenase (COX)-1 activity was assessed by measuring serum thromboxane (TX)B2 or urinary 11-dehydro TXB2. Shear-induced platelet thrombus formation was also examined. We followed all patients for two years to evaluate how these seven indexes were related to the recurrence of CVEs (cerebral infarction, transient ischaemic attack, myocardial infarction, unstable angina, revascularisation, other arterial thrombosis, or cardiovascular death). Of 583 patients eligible for the analysis, CVEs occurred in 69 (11.8%). A Cox regression model identified several classical risk factors associated with CVEs. However, neither HTPR nor high residual COX-1 activity was significantly associated with CVEs, even by applying cut-off values suggested in previous reports or a receiver-operating characteristic analysis. In conclusion, recurrence of CVEs occurred independently of HTPR and residual COX-1 activity. Thus, our findings do not support the use of platelet or COX-1 functional testing for predicting clinical outcomes in stable cardiovascular patients. Supplementary Material to this article is available at www.thrombosis-online.com.
    Type of Medium: Online Resource
    ISSN: 0340-6245 , 2567-689X
    URL: Article
    DOI: 10.1160/TH15-11-0864
    Language: English
    Publisher: Georg Thieme Verlag KG
    Publication Date: 2016
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  • 8
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    Increased Tissue Factor Pathway Inhibitor Levels in Uremic Patients on Regular Hemodialysis
    Georg Thieme Verlag KG ; 1994
    In:  Thrombosis and Haemostasis Vol. 71, No. 03 ( 1994), p. 275-279
    Details
    In: Thrombosis and Haemostasis, Georg Thieme Verlag KG, Vol. 71, No. 03 ( 1994), p. 275-279
    Abstract: We investigated tissue factor pathway inhibitor (TFPI) levels in 44 non-dialysis uremic patients and 36 chronic dialysis patients, as well as the changes of TFPI levels during hemodialysis sessions using heparin (n = 14), low molecular weight heparin (n = 7), nafamostat mesilate (n = 5), and argatroban (n = 2). In non-dialysis uremic patients, TFPI levels increased (mean ± SD: 178 ± 37% of control pooled plasma) along with the impairment of renal function. In chronic hemodialysis patients, TFPI levels were even higher (265 ± 72%) before dialysis, but did not depend on the etiology of renal failure (diabetic or non-diabetic), the interval between dialysis sessions (twice or three times a week), and the duration of hemodialysis. During hemodialysis sessions using heparin, TFPI levels increased 1.2-to 3.5-fold compared with the level before hemodialysis and the degree of increase in TFPI was correlated with the heparin concentration (r = 0.648, p = 0.0001, n = 29). During dialysis sessions using low molecular weight heparin, TFPI levels also increased, but the change was less marked than during dialysis with heparin. TFPI levels did not change during dialysis sessions using nafamostat mesilate or argatroban. In conclusion, TFPI levels were increased by renal failure and by long-term repeated injection of heparin, but the hemodialysis procedure itself did not alter the TFPI level.
    Type of Medium: Online Resource
    ISSN: 0340-6245 , 2567-689X
    URL: Article
    DOI: 10.1055/s-0038-1642429
    Language: English
    Publisher: Georg Thieme Verlag KG
    Publication Date: 1994
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  • 9
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    Increased plasma plasminogen activator inhibitor-1 levels caused by additional aspirin treatment
    Georg Thieme Verlag KG ; 2006
    In:  Thrombosis and Haemostasis Vol. 95, No. 05 ( 2006), p. 906-907
    Details
    In: Thrombosis and Haemostasis, Georg Thieme Verlag KG, Vol. 95, No. 05 ( 2006), p. 906-907
    Type of Medium: Online Resource
    ISSN: 0340-6245 , 2567-689X
    URL: Article
    DOI: 10.1160/TH06-01-0032
    Language: English
    Publisher: Georg Thieme Verlag KG
    Publication Date: 2006
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  • 10
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    The Strong Positive Correlation between Factor VII Clotting Activity Using Bovine Thromboplastin and the Activated Factor VII Level
    Georg Thieme Verlag KG ; 1995
    In:  Thrombosis and Haemostasis Vol. 73, No. 03 ( 1995), p. 429-434
    Details
    In: Thrombosis and Haemostasis, Georg Thieme Verlag KG, Vol. 73, No. 03 ( 1995), p. 429-434
    Abstract: We compared factor VII clotting activity (FVIIc) assays using different thromboplastins to determine which is the most sensitive for activated FVII (FVIIa) or for FVII antigen (FVIIag). FVIIc levels were measured using thromboplastins derived from bovine brain (FVIIc Bov), human placenta (FVIIc Hum), and rabbit brain (FVIIc Rab). FVIIa levels were measured by fluorogenic assays using human soluble tissue factor (rsTF) or bovine rsTF. We also measured FVII activity by an amidolytic assay (FVIIc:am Hum) using human thromboplastin and a chromogenic substrate for thrombin. FVIIag levels were determined by ELISA. In the FVIIa assay, the reaction time obtained from using bovine rsTF was shorter than that with human rsTF, suggesting that the interaction of plasma FVIIa with bovine rsTF was stronger than with human rsTF. The plasma FVIIa levels measured using human rsTF and bovine rsTF were almost the same (r=0.947, p 〈 0.0001). Among the three FVIIc assays, FVIIc Bov had the strongest positive correlation with the plasma FVIIa level (r=0.886, p 〈 0.000l), but had no correlation with FVIIag. An increase of 1 ng/ml in the plasma FVIIa level yielded a 27.9% increase of FVIIc Bov. Plasma FVIIc Hum and FVIIc:am Hum showed moderate correlations with both FVIIa (r=0.520, p 〈 0.02 and r=0.569, p 〈 0.01, respectively) and FVIIag (r=0.438, p 〈 0.05 and r=0.468, p 〈 0.05, respectively). FVIIc Rab had the lowest correlation with FVIIa (r=0.367, p 〈 0.1), but had a moderate correlation with FVIIag (r=0.436, p 〈 0.05). After in vitro cold activation, FVIIc Bov levels increased the most and FVIIc:am levels showed the least change. These findings indicate that consideration of the thromboplastin used for assay is necessary when assessing the clinical significance of FVII activity as a cardiovascular risk factor.
    Type of Medium: Online Resource
    ISSN: 0340-6245 , 2567-689X
    URL: Article
    DOI: 10.1055/s-0038-1653792
    Language: English
    Publisher: Georg Thieme Verlag KG
    Publication Date: 1995
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