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  • 1
    Online Resource
    Online Resource
    Georg Thieme Verlag KG ; 2008
    In:  Indian Journal of Medical and Paediatric Oncology Vol. 29, No. 02 ( 2008-04), p. 44-46
    In: Indian Journal of Medical and Paediatric Oncology, Georg Thieme Verlag KG, Vol. 29, No. 02 ( 2008-04), p. 44-46
    Abstract: Soft tissue and bone secondaries in supraglottic carcinoma are extremely rare. A 55 year old male presented with history of hoarseness of voice, lump in left side of neck and pain in right shoulder region. Patient underwent Radiotherapy to primary as well as metastatic sites. After 10 months of follow-up, patient presented with distant metastasis to left shoulder, lumbar vertebra and sacrum. This case is being reported on account of its rarity.
    Type of Medium: Online Resource
    ISSN: 0971-5851 , 0975-2129
    Language: English
    Publisher: Georg Thieme Verlag KG
    Publication Date: 2008
    detail.hit.zdb_id: 2181724-8
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  • 2
    Online Resource
    Online Resource
    Georg Thieme Verlag KG ; 2010
    In:  Indian Journal of Medical and Paediatric Oncology Vol. 31, No. 02 ( 2010-04), p. 58-61
    In: Indian Journal of Medical and Paediatric Oncology, Georg Thieme Verlag KG, Vol. 31, No. 02 ( 2010-04), p. 58-61
    Abstract: Pseudomyxoma peritonei is a poorly understood and uncommon tumor that is known for its production of mucin in the abdominal cavity and mucinous implants, diffusely involving the peritoneal surfaces. A 60-year-old female presented to us with post-op complaints of diffuse abdominal pain and distension. On work-up, she was diagnosed as a case of Pseudomyxoma peritonei (with residual disease). She received chemotherapy in the form of oral capecitabine for residual disease. She was totally asymptomatic till the last follow-up. This case is being reported on account of its rarity and to emphasize a simple alternative treatment option as compared to the standard one.
    Type of Medium: Online Resource
    ISSN: 0971-5851 , 0975-2129
    Language: English
    Publisher: Georg Thieme Verlag KG
    Publication Date: 2010
    detail.hit.zdb_id: 2181724-8
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  • 3
    Online Resource
    Online Resource
    Georg Thieme Verlag KG ; 2021
    In:  Indian Journal of Radiology and Imaging Vol. 31, No. 03 ( 2021-07), p. 789-790
    In: Indian Journal of Radiology and Imaging, Georg Thieme Verlag KG, Vol. 31, No. 03 ( 2021-07), p. 789-790
    Type of Medium: Online Resource
    ISSN: 0971-3026 , 1998-3808
    Language: English
    Publisher: Georg Thieme Verlag KG
    Publication Date: 2021
    detail.hit.zdb_id: 2059213-9
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  • 4
    Online Resource
    Online Resource
    Georg Thieme Verlag KG ; 2020
    In:  Indian Journal of Radiology and Imaging Vol. 30, No. 03 ( 2020-07), p. 294-303
    In: Indian Journal of Radiology and Imaging, Georg Thieme Verlag KG, Vol. 30, No. 03 ( 2020-07), p. 294-303
    Abstract: Context: Pancreatic masses are routinely encountered on imaging and often present as a diagnostic dilemma. These masses range from benign inflammatory masses, requiring no intervention to malignant masses, which carry grave prognosis and hence require aggressive management. Aims: Compare the diagnostic accuracy of 256 multislice CT and endoscopic ultrasound (EUS) in characterization and assessment of resectability of pancreatic masses and compare the multidetector computed tomography (MDCT) and EUS findings with histopathological findings. Settings and Design: Prospective study. Subjects and Methods: 36 patients with pancreatic masses were included who underwent dual phase CT using pancreatic protocol and EUS using 5–13 MHz transducer. Fine needle aspiration cytology (FNAC) was done wherever feasible. Parameters regarding tumor size, location, imaging morphology, and vessel involvement were recorded. Findings were compared with histopathological/operative diagnosis/clinical follow-up. Statistical Analysis Used: Descriptive statistics with percentages and proportions and Chi-square test. Results: Multidetector computed tomography (MDCT) and EUS established diagnosis consistent with tissue diagnosis in 30 (83%) and 22 (61%) patients, respectively. However, the best results were obtained with the combined use of MDCT and EUS. The number of patients categorized as inconclusive by MDCT were lower compared to EUS. Assessing resectability for pancreatic adenocarcinoma, MDCT showed specificity and positive predictive value (PPV) of 100% compared to EUS, which had specificity and PPV of 75% and 92.3%, respectively. MDCT is the first-line imaging modality in detection, characterization of pancreatic masses, and assessment of resectability in malignant neoplasms. EUS is beneficial in the detection of masses 〈 2 cm in size causing pancreatic contour deformity on CT, for guiding FNAC. MDCT and EUS with EUS-guided FNA are complementary not competitive tools in preoperative imaging of pancreatic masses.
    Type of Medium: Online Resource
    ISSN: 0971-3026 , 1998-3808
    Language: English
    Publisher: Georg Thieme Verlag KG
    Publication Date: 2020
    detail.hit.zdb_id: 2059213-9
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  • 5
    Online Resource
    Online Resource
    Georg Thieme Verlag KG ; 2019
    In:  Synthesis Vol. 51, No. 10 ( 2019-05), p. 2171-2182
    In: Synthesis, Georg Thieme Verlag KG, Vol. 51, No. 10 ( 2019-05), p. 2171-2182
    Abstract: N-Arylation of sulfoximines with different arylboronic acids, including sterically hindered boronic acids, is achieved using copper(I) iodide and 4-DMAP at room temperature. Moreover, N-arylation of biologically relevant l-methionine sulfoximine is demonstrated for the first time. All these reactions provided the desired products in excellent yields within a short span of time. The optimized reaction conditions are well suited to the task of N-vinylation of sulfoximine with trans-2-phenylvinylboronic acid.
    Type of Medium: Online Resource
    ISSN: 0039-7881 , 1437-210X
    RVK:
    Language: English
    Publisher: Georg Thieme Verlag KG
    Publication Date: 2019
    detail.hit.zdb_id: 204080-3
    detail.hit.zdb_id: 2033062-5
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  • 6
    Online Resource
    Online Resource
    Georg Thieme Verlag KG ; 2020
    In:  Annals of the National Academy of Medical Sciences (India) Vol. 56, No. 01 ( 2020-01), p. 30-37
    In: Annals of the National Academy of Medical Sciences (India), Georg Thieme Verlag KG, Vol. 56, No. 01 ( 2020-01), p. 30-37
    Abstract: Subclinical hypothyroid men characterized by a rise in only thyroid stimulating hormone (TSH) levels, and normal thyroid hormone levels showed a fall in their serum progesterone and testosterone levels. This suggested a role of TSH in regulating Leydig cell steroidogenesis. Therefore, we investigated the direct role of TSH on steroid production and secretion using a mouse Leydig tumor cell line-1 (MLTC-1). MLTC-1 cells were treated with different doses of TSH isolated from porcine pituitary as well as recombinant TSH. Steroid secretion was measured by radioimmunoassay (RIA). The mRNA levels of steroidogenic enzymes were quantitated by real-time polymerase chain reaction (RT-PCR), whereas the corresponding protein levels were determined by western blot. In MLTC-1 cells, pituitary TSH as well as recombinant TSH inhibited progesterone and testosterone secretion in a dose-dependent manner. The inhibitory action of TSH on steroid secretion was unique and not mimicked by other anterior pituitary hormones including follicle stimulating hormone and adrenocorticotropic hormone. Recombinant TSH showed no effect on steroidogenic acute regulatory protein and CYP11A1, the enzymes catalyzing the nonsteroidogenic and steroidogenic rate-limiting steps of steroid synthesis, respectively. Recombinant TSH was shown to inhibit steroidogenesis in MLTC-1 cells by inhibiting the 3-β hydroxy steroid dehydrogenase mRNA and protein levels, the enzyme that catalyzes the conversion of pregnenolone to progesterone. This inhibitory effect of TSH is probably direct as both mRNA and protein of the TSH receptor were shown to be present in the MLTC-1 cells.
    Type of Medium: Online Resource
    ISSN: 0379-038X , 2454-5635
    Language: English
    Publisher: Georg Thieme Verlag KG
    Publication Date: 2020
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