In:
Synthesis, Georg Thieme Verlag KG, Vol. 51, No. 18 ( 2019-09), p. 3419-3430
Abstract:
This paper describes a concise, easy-operation, high-yielding method for the synthesis of 3-sulfonyl-2-aryl-2H-chromenes by a one-pot, straightforward two-step synthetic route, which includes (i) Cu(OAc)2/PyBOP-mediated intermolecular [4+2] annulation of substituted salicylic acids with β-sulfonylstyrenes in the presence of DMAP in refluxing DMF, and (ii) sequential O-alkylation of the resulting sulfonylflavanones with n-butyl bromide. A plausible mechanism is proposed and discussed. This protocol provides a highly effective annulation via one carbon–oxygen (C–O) and one carbon–carbon (C–C) bond formations.
Type of Medium:
Online Resource
ISSN:
0039-7881
,
1437-210X
DOI:
10.1055/s-0039-1689973
Language:
English
Publisher:
Georg Thieme Verlag KG
Publication Date:
2019
detail.hit.zdb_id:
204080-3
detail.hit.zdb_id:
2033062-5
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