In:
Synlett, Georg Thieme Verlag KG, Vol. 33, No. 19 ( 2022-12), p. 1917-1924
Abstract:
A novel method for assembling pyrrolidine-2,4-diones from 1,5-enenitriles and acetone/acetonitrile via a cyclization/hydrolysis has been established under metal-catalyst- and base-free conditions, with Oxone as a green oxidant and H2O as an additive at 90–110 ℃. This strategy is highlighted by cyclization/hydrolysis of alkyl cyanides, achieving direct C(sp3)–H oxidative functionalization, and giving full conversion of the substrates with excellent functional group compatibility.
Type of Medium:
Online Resource
ISSN:
0936-5214
,
1437-2096
Language:
English
Publisher:
Georg Thieme Verlag KG
Publication Date:
2022
detail.hit.zdb_id:
1009657-7
detail.hit.zdb_id:
2042012-2
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