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  • 1
    Electronic Resource
    Electronic Resource
    New York, NY [u.a.] : Wiley-Blackwell
    Molecular Reproduction and Development 27 (1990), S. 93-101 
    ISSN: 1040-452X
    Keywords: Somatomedin ; sis protooncogene ; Menstrual cycle ; Endometrium ; Myometrium ; Leiomyoma ; Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
    Notes: The human uterus repeatedly exhibits cyclic biochemical and cytological changes during the reproductive period of life. These changes are the result of a well-characterized endocrine network involving the hypothalamus, pituitary, and ovary. The exact nature of the mechanism(s) by which the sex steroids act on the uterus remains to be elucidated. Possible local mediators of hormonal action on the uterus include polypeptide growth factors. Using the method of RNA transfer blot hybridization, we have analyzed tissue samples from the cycling human endometrium and tissue samples of human myometrium and myometrial benign tumor (leiomyoma) for the presence of platelet-derived growth factor (PDGF) and insulin-like growth factor (IGF) RNA. All the uterine tissues examined possessed RNA for PDGF-B chain and IGF-I and -II. Two transcripts were observed for PDGF-B chain, four were observed for IGF-I, and eight were observed for IGF-II. Overall, the relative abundance of PDGF-B chain RNA was consistent in all of the uterine tissues examined. In contrast, IGF RNA relative abundance varied. IGF-I RNA was highest in late proliferative stage endometrium, and IGF-II RNA was highest in early proliferative stage endometrium. Both IGF-I and IGF-II RNAs were greater in amount in leiomyoma than in myometrium. The increased IGF-I RNA in late proliferative-stage human endometrium correlates with the known elevation of estradiol secretion by the ovary and the increased concentration of uterine estradiol receptors during this stage of the menstrual cycle. Furthermore, these data are consistent with reports of increased IGF-I RNA in the rat uterus in response to administration of estradiol. Elevated levels of IGF RNA in leiomyomas may be related to the genesis and/or progression of these myometrial tumors.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
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  • 2
    Publication Date: 2020-02-12
    Description: The scope of the Science Plan is to describe the scientific background, applications, and activities related to the Environmental Mapping and Analysis Program (EnMAP) mission. Primarily, the document addresses scientists and funding institutions, but it may also be of interest for environmental stakeholders and governmental bodies. It is conceived to be a living document that will be updated throughout the entire mission. Chapter 1 provides a brief overview of the principles and current state of imaging spectroscopy. This is followed by an introduction to the EnMAP mission, including its objectives and potential impact on international programs as well as major environmental and societal challenges to their understanding and management EnMAP can contribute. Chapter 2 describes the EnMAP system together with data products and access, calibration/validation issues, and synergies with other missions. Chapter 3 gives an overview of the relevance, current lines of research, and potential contributions of EnMAP for major fields of application, such as vegetation, geology and soils, coastal and inland waters, cryosphere, urban areas, atmosphere and hazards to address the environmental and societal challenges presented in Chapter 1. Finally, Chapter 4 outlines the scientific exploitation strategy, which includes the strategy for community building and training, preparatory flight campaigns and software developments. A list of abbreviations is provided in the annex to this document, while an extended glossary of terms and abbreviations is available at the EnMAP website.
    Language: English
    Type: info:eu-repo/semantics/report
    Format: application/pdf
    Location Call Number Limitation Availability
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  • 3
    Publication Date: 2020-02-12
    Description: The scope of this Science Plan is to describe the scientific background, applications, and activities related to the EnMAP mission. Primarily, the Science Plan addresses scientists and funding institutions, but it may also be of interest for environmental stakeholders and governmental bodies. It is conceived to be a living document that will be updated throughout the whole mission. Current global challenges call for interdisciplinary approaches. Hence, the science plan is not structured in the traditional disciplinary way. Instead, it builds on overarching research themes to which EnMAP can contribute. This Science Plan comprises the following five chapters presenting the significance, background, framework, applications, and strategy of the EnMAP mission: Chapter 2 highlights the need for EnMAP data with respect to major environmental issues and various stakeholders. This chapter states the mission’s main objectives and provides a list of research themes addressing global challenges to whose understanding and management EnMAP can contribute. Chapter 3 presents an overview of the EnMAP mission from a scientific point of view including a brief description of the mission parameters, data products and access, and calibration/validation issues. Chapter 4 provides an overview of hyperspectral remote sensing regarding its principles, development, and current state and synergies to other satellite missions. Chapter 5 describes current lines of research and EnMAP applications to address the research themes presented in Chapter 2. Finally, Chapter 6 outlines the scientific exploitation strategy, which includes the strategy for community building, dissemination of knowledge and increasing public awareness.
    Language: English
    Type: info:eu-repo/semantics/report
    Format: application/pdf
    Format: application/pdf
    Location Call Number Limitation Availability
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  • 4
    Publication Date: 2022-12-06
    Description: The scope of the Science Plan is to describe the scientific background, applications, and activities of the Environmental Mapping and Analysis Program (EnMAP) imaging spectroscopy mission. Primarily, this document addresses scientists and funding institutions, but it may also be of interest to environmental stakeholders and governmental agencies. It is designed to be a living document that will be updated throughout the entire mission lifetime. Chapter 1 provides a brief overview of the principles and current state of imaging spectroscopy. This is followed by an introduction to the EnMAP mission, including its objectives and impact on international programs as well as major environmental and societal challenges. Chapter 2 describes the EnMAP system together with data products and access, calibration/validation, and synergies with other missions. Chapter 3 gives an overview of the major fields of application such as vegetation and forests, geology and soils, coastal and inland waters, cryosphere, urban areas, atmosphere and hazards. Finally, Chapter 4 outlines the scientific exploitation strategy, which includes the strategy for community building and training, preparatory flight campaigns and software developments. A list of abbreviations is provided in the annex to this document and an extended glossary of terms and abbreviations is available on the EnMAP website.
    Language: English
    Type: info:eu-repo/semantics/report
    Format: application/pdf
    Location Call Number Limitation Availability
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