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  • 1
    Publication Date: 2015-01-17
    Description: BACKGROUND Familial dysautonomia (FD) is a rare hereditary disease characterized by loss of afferent autonomic neural fiber signaling and consequent profound impairment of arterial baroreflex function and blood pressure regulation. Whether vascular endothelial dysfunction contributes to defective vasomotor control in this form of afferent autonomic failure is not known. METHODS We assessed blood pressure response to orthostatic stress and vascular endothelial function with brachial artery reactivity testing in 34 FD subjects with afferent autonomic failure and 34 healthy control subjects. RESULTS Forty-four percent of the afferent autonomic failure subjects had uncontrolled hypertension at supine rest (median systolic blood pressure = 148mm Hg, interquartile range (IQR) = 144–155mm Hg; median diastolic blood pressure = 83mm Hg, IQR = 78–105mm Hg), and 88% had abnormal response to orthostatic stress (median decrease in systolic blood pressure after upright tilt = 48mm Hg, IQR = 29–61mm Hg). Flow-mediated brachial artery reactivity did not differ in subjects with afferent autonomic failure vs. healthy control subjects (median = 6.00%, IQR = 1.86–11.77%; vs. median = 6.27%, IQR = 4.65–9.34%; P = 0.75). In afferent autonomic failure subjects, brachial artery reactivity was not associated with resting blood pressure or the magnitude of orthostatic hypotension but was decreased in association with reduced glomerular filtration rate ( r = 0.62; P 〈 0.001). CONCLUSIONS Brachial artery reactivity was preserved in subjects with afferent autonomic failure despite the presence of marked blood pressure dysregulation. Comorbid renal dysfunction was associated with reduced brachial artery reactivity.
    Print ISSN: 0895-7061
    Electronic ISSN: 1879-1905
    Topics: Medicine
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  • 2
    Publication Date: 2020-02-12
    Description: The scope of the Science Plan is to describe the scientific background, applications, and activities related to the Environmental Mapping and Analysis Program (EnMAP) mission. Primarily, the document addresses scientists and funding institutions, but it may also be of interest for environmental stakeholders and governmental bodies. It is conceived to be a living document that will be updated throughout the entire mission. Chapter 1 provides a brief overview of the principles and current state of imaging spectroscopy. This is followed by an introduction to the EnMAP mission, including its objectives and potential impact on international programs as well as major environmental and societal challenges to their understanding and management EnMAP can contribute. Chapter 2 describes the EnMAP system together with data products and access, calibration/validation issues, and synergies with other missions. Chapter 3 gives an overview of the relevance, current lines of research, and potential contributions of EnMAP for major fields of application, such as vegetation, geology and soils, coastal and inland waters, cryosphere, urban areas, atmosphere and hazards to address the environmental and societal challenges presented in Chapter 1. Finally, Chapter 4 outlines the scientific exploitation strategy, which includes the strategy for community building and training, preparatory flight campaigns and software developments. A list of abbreviations is provided in the annex to this document, while an extended glossary of terms and abbreviations is available at the EnMAP website.
    Language: English
    Type: info:eu-repo/semantics/report
    Format: application/pdf
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  • 3
    Publication Date: 2020-02-12
    Description: The scope of this Science Plan is to describe the scientific background, applications, and activities related to the EnMAP mission. Primarily, the Science Plan addresses scientists and funding institutions, but it may also be of interest for environmental stakeholders and governmental bodies. It is conceived to be a living document that will be updated throughout the whole mission. Current global challenges call for interdisciplinary approaches. Hence, the science plan is not structured in the traditional disciplinary way. Instead, it builds on overarching research themes to which EnMAP can contribute. This Science Plan comprises the following five chapters presenting the significance, background, framework, applications, and strategy of the EnMAP mission: Chapter 2 highlights the need for EnMAP data with respect to major environmental issues and various stakeholders. This chapter states the mission’s main objectives and provides a list of research themes addressing global challenges to whose understanding and management EnMAP can contribute. Chapter 3 presents an overview of the EnMAP mission from a scientific point of view including a brief description of the mission parameters, data products and access, and calibration/validation issues. Chapter 4 provides an overview of hyperspectral remote sensing regarding its principles, development, and current state and synergies to other satellite missions. Chapter 5 describes current lines of research and EnMAP applications to address the research themes presented in Chapter 2. Finally, Chapter 6 outlines the scientific exploitation strategy, which includes the strategy for community building, dissemination of knowledge and increasing public awareness.
    Language: English
    Type: info:eu-repo/semantics/report
    Format: application/pdf
    Format: application/pdf
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  • 4
    Publication Date: 2022-12-06
    Description: The scope of the Science Plan is to describe the scientific background, applications, and activities of the Environmental Mapping and Analysis Program (EnMAP) imaging spectroscopy mission. Primarily, this document addresses scientists and funding institutions, but it may also be of interest to environmental stakeholders and governmental agencies. It is designed to be a living document that will be updated throughout the entire mission lifetime. Chapter 1 provides a brief overview of the principles and current state of imaging spectroscopy. This is followed by an introduction to the EnMAP mission, including its objectives and impact on international programs as well as major environmental and societal challenges. Chapter 2 describes the EnMAP system together with data products and access, calibration/validation, and synergies with other missions. Chapter 3 gives an overview of the major fields of application such as vegetation and forests, geology and soils, coastal and inland waters, cryosphere, urban areas, atmosphere and hazards. Finally, Chapter 4 outlines the scientific exploitation strategy, which includes the strategy for community building and training, preparatory flight campaigns and software developments. A list of abbreviations is provided in the annex to this document and an extended glossary of terms and abbreviations is available on the EnMAP website.
    Language: English
    Type: info:eu-repo/semantics/report
    Format: application/pdf
    Location Call Number Limitation Availability
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  • 5
    Publication Date: 2020-02-12
    Type: info:eu-repo/semantics/workingPaper
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