In:
Therapeutic Delivery, Future Science Ltd, Vol. 11, No. 9 ( 2020-09), p. 557-571
Abstract:
Aim: This work focused on the development of transferrin-conjugated theranostic liposomes consisting of docetaxel (DXL) and upconversion nanoparticles for the diagnosis and treatment of gliomas. Materials & methods: Upconversion nanoparticles and docetaxel-loaded theranostic liposomes were prepared by a solvent injection method. Formulations were analyzed for physicochemical properties, encapsulation efficiency, drug release, elemental analysis, cytotoxicity and fluorescence. Results: The particle size was around 200 nm with spherical morphology and an encapsulation efficiency of up to 75.93%, was achieved for liposomes with an in vitro drug release of 71.10%. The IC 50 values demonstrated enhanced cytotoxicity on C6 glioma cells with targeted liposomes in comparison with nontargeted liposomes. Conclusion: Prepared theranostic liposomes may be promising for clinical validation after an in vitro and in vivo evaluation on cell lines and animals, respectively.
Type of Medium:
Online Resource
ISSN:
2041-5990
,
2041-6008
DOI:
10.4155/tde-2020-0070
Language:
English
Publisher:
Future Science Ltd
Publication Date:
2020
SSG:
15,3
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