In:
Nanomedicine, Future Medicine Ltd, Vol. 12, No. 10 ( 2017-05), p. 1119-1133
Abstract:
Aim: Nanoparticle-based drug carriers hold great promise for the development of targeted therapies in pregnancy with reduced off-target effects. Here, we performed a mechanistic in vitro study on placental localization and penetration of gold nanoparticles (AuNPs) in dependence of particle size and surface modification. Materials & methods: AuNP uptake and penetration in human placental coculture microtissues was assessed by inductively coupled plasma-mass spectrometry, transmission electron microscopy and laser ablation-inductively coupled plasma-mass spectrometry. Results: Higher uptake and deeper penetration was observed for smaller (3–4 nm) or sodium carboxylate-modified AuNPs than for larger (13–14 nm) or PEGylate AuNPs, which barely passed the trophoblast barrier layer. Conclusion: It is possible to steer placental uptake and penetration of AuNPs by tailoring their properties, which is a prerequisite for the development of targeted therapies in pregnancy.
Type of Medium:
Online Resource
ISSN:
1743-5889
,
1748-6963
DOI:
10.2217/nnm-2017-0428
Language:
English
Publisher:
Future Medicine Ltd
Publication Date:
2017
SSG:
15,3
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