In:
Biomarkers in Medicine, Future Medicine Ltd, Vol. 15, No. 5 ( 2021-04), p. 337-345
Abstract:
Aim: The present study observed the relationship between the methylenetetrahydrofolate reductase genotypes and clinical outcome in children with sickle cell disorder. Methodology: A total of 249 children were recruited for the study and evaluated clinically for calculating severity score, homocysteine levels and C677T and A1298C genotyping. Results: The frequencies of variant genotypes were 28.1% CT/TT677 and 69.1% AC/CC1298. Plasma homocysteine was significantly elevated in variant groups (p 〈 0.001). Both the genotypes accorded significant association with homocysteinemia (p 〈 0.001). Vascular crisis (p = 0.04), frequency of hospitalization (p 〈 0.001) and severity score (p = 0.02) revealed association with C677T and not with A1298C. The CT/TT677 genotypes showed 3.39-times (p = 0.032) increase in a higher score for severity. Conclusion: C677T depicted significant association with clinical severity in study population.
Type of Medium:
Online Resource
ISSN:
1752-0363
,
1752-0371
DOI:
10.2217/bmm-2020-0613
Language:
English
Publisher:
Future Medicine Ltd
Publication Date:
2021
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