In:
Future Virology, Future Medicine Ltd, Vol. 12, No. 10 ( 2017-10), p. 593-607
Abstract:
Oncoviruses are collectively responsible for over 1,000,000 new cases of cancer per year; some can integrate into the host's chromosomes. The present work was aimed at assessing the proportion of transcriptionally active viral integrants through a systematic review of the scientific publications present on the MedLine database. From the articles screened, 628 viral integrants overall were retrieved, of which 530.84 were transcriptionally active (84.53%); among the clinical samples, 264 of 323 integrants were active (81.73%). The causes for the silencing were not addressed in the articles analyzed. These findings might highlight a possible risk factor for the insurgence of cancer since some oncovirus integrants could be reactivated by stimuli of disparate nature. Further studies should address such possibility.
Type of Medium:
Online Resource
ISSN:
1746-0794
,
1746-0808
DOI:
10.2217/fvl-2017-0063
Language:
English
Publisher:
Future Medicine Ltd
Publication Date:
2017
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