In:
Future Oncology, Future Medicine Ltd, Vol. 15, No. 19 ( 2019-07), p. 2303-2317
Abstract:
Aim: To provide clarity surrounding the association between tumor-associated macrophages (TAMs) and esophageal cancer prognosis. Materials & methods: Several databases were searched. The meta-analysis was conducted by using software Stata 12.0 and Revman. Results: Sixteen studies were included in this analysis (2292 samples). CD68 + TAM density was not associated with overall survival (OS; hazard ratio [HR]: 0.88, 95% CI: 0.67–1.15; p = 0.33) and disease-free survival (HR: 1.25, 95% CI: 0.66–2.35; p = 0.49). M2-like TAMs were associated with poor overall survival (HR: 1.47, 95% CI: 1.10–1.98; p = 0.01), Tumor, Node, Metastasis staging and vessel metastasis. Conclusion: CD68 + TAM density is not associated with esophageal cancer progression, while CD163 + M2-like TAMs is a potential risk factor.
Type of Medium:
Online Resource
ISSN:
1479-6694
,
1744-8301
DOI:
10.2217/fon-2018-0669
Language:
English
Publisher:
Future Medicine Ltd
Publication Date:
2019
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