In:
Epigenomics, Future Medicine Ltd, Vol. 11, No. 6 ( 2019-05), p. 605-617
Abstract:
Aim: To provide a breast cancer (BC) methylotype classification by genome-wide CpG islands bisulfite DNA sequencing. Materials & methods: XmaI-reduced representation bisulfite sequencing DNA methylation sequencing method was used to profile DNA methylation of 110 BC samples and 6 normal breast samples. Intrinsic DNA methylation BC subtypes were elicited by unsupervised hierarchical cluster analysis, and cluster-specific differentially methylated genes were identified. Results & conclusion: Overall, six distinct BC methylotypes were identified. BC cell lines constitute a separate group extremely highly methylated at the CpG islands. In turn, primary BC samples segregate into two major subtypes, highly and moderately methylated. Highly and moderately methylated superclusters, each incorporate three distinct epigenomic BC clusters with specific features, suggesting novel perspectives for personalized therapy.
Type of Medium:
Online Resource
ISSN:
1750-1911
,
1750-192X
DOI:
10.2217/epi-2018-0213
Language:
English
Publisher:
Future Medicine Ltd
Publication Date:
2019
SSG:
12
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