In:
Future Neurology, Future Medicine Ltd, Vol. 13, No. 2 ( 2018-05), p. 87-99
Abstract:
Pathological remodeling, degeneration and reactivity of astrocytes are fundamental astrogliopathies contributing to all neurological diseases. In neurodegenerative disorders (including Alzheimer's disease [AD]) astroglia undergo complex changes that range from atrophy with loss of function to accumulation of reactive cells around disease-specific lesions (senile plaques in the case of AD). The cellular pathology of astroglia in the context of human AD remains enigmatic; mainly because of the severe limitations of animal models, which, although reproducing some pathological features of the disease, do not mimic its progression in full. Human-induced plu ripotent stem cells technology creates a novel and potentially revolutionizing platform for studying fundamental mechanisms of the disease and for screening to identify new therapeutic compounds.
Type of Medium:
Online Resource
ISSN:
1479-6708
,
1748-6971
DOI:
10.2217/fnl-2017-0029
Language:
English
Publisher:
Future Medicine Ltd
Publication Date:
2018
detail.hit.zdb_id:
2254603-0
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