In:
Future Virology, Future Medicine Ltd, Vol. 15, No. 2 ( 2020-02), p. 101-126
Abstract:
Graphical abstract The proposed impact of Mycobacterium tuberculosis ( Mtb) coinfection (solid lines) on the life-course progression of HIV-1 infection (dotted lines). In addition to enhancing the speed of AIDS progression and tuberculosis development in those HIV-1 infected, Mtb infection increases myeloid and T-cell immune activation and the susceptibility of cells to HIV-1 infection and HIV-1 replication in infected and bystander cells. Following antiretroviral therapy initiation, a larger pool of reservoir cells harboring HIV-1 and higher immune activation status has the potential to result in more frequent blips in viremia above the level of clinical detection (thin line). [Formula: see text]
Type of Medium:
Online Resource
ISSN:
1746-0794
,
1746-0808
DOI:
10.2217/fvl-2019-0069
Language:
English
Publisher:
Future Medicine Ltd
Publication Date:
2020
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