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  • Future Medicine Ltd  (2)
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  • Future Medicine Ltd  (2)
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  • 1
    Online Resource
    Online Resource
    Comparing different nanofat procedures on scars: role of the stromal vascular fraction and its clinical implications
    Future Medicine Ltd ; 2017
    In:  Regenerative Medicine Vol. 12, No. 8 ( 2017-12), p. 939-952
    Details
    In: Regenerative Medicine, Future Medicine Ltd, Vol. 12, No. 8 ( 2017-12), p. 939-952
    Abstract: Aim: Recently, a new fat grafting technique termed ‘nanofat grafting’ was proposed which improved tissue repair by the stem cells contained in the stromal vascular fraction (SVF) of nanofat. Here, we reported the clinical outcomes of different nanofat procedures in the treatment of scars in relation with SVF cell yield. Methods: Three different modified nanofat grafting procedures (supercharged-, evo- and centrifuged-modified nanofat) were compared with the classic nanofat method, and histological analysis was performed to assess skin regeneration. Residual nanofat samples were analyzed to determine SVF immunophenotype and yield from each procedure. Results: Supercharged-modified nanofat gave the best results in terms of clinical outcome and SVF yield. Histological analysis revealed similar skin regeneration in all treatments. Conclusion: This work suggested a positive correlation between SVF yield and clinical outcomes in the nanofat treatment of scars.
    Type of Medium: Online Resource
    ISSN: 1746-0751 , 1746-076X
    URL: Article
    DOI: 10.2217/rme-2017-0076
    Language: English
    Publisher: Future Medicine Ltd
    Publication Date: 2017
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    Online Resource
  • 2
    Online Resource
    Online Resource
    Adipose-derived stem cells in cartilage regeneration: current perspectives
    Future Medicine Ltd ; 2016
    In:  Regenerative Medicine Vol. 11, No. 7 ( 2016-10), p. 693-703
    Details
    In: Regenerative Medicine, Future Medicine Ltd, Vol. 11, No. 7 ( 2016-10), p. 693-703
    Abstract: Repair of cartilage injuries represents a musculoskeletal medicine criticism because of the poor ability to self-renewal of adult cartilage. Therefore, research focuses on developing new regenerative strategies combining chondrocytes or stem cells, scaffolds and growth factors. Because of the low proliferation capability of explanted chondrocytes, new chondrogenesis models, employing human adipose-derived stem cells (ASCs), have been investigated. ASCs are readily accessible with no morbidity and display the capability to differentiate into several cell lineages, including the spontaneous chondrogenic differentiation when entrapped in collagen gel scaffolds. Recent studies also defined some biomolecular mechanisms involved in ASC chondrogenesis in vitro, and their regenerative properties in bioengineered scaffolds and in the presence of growth factors. However, further investigations are required to validate these exciting preclinical results for the application of bioenginereed ASCs in the clinical practice.
    Type of Medium: Online Resource
    ISSN: 1746-0751 , 1746-076X
    URL: Article
    DOI: 10.2217/rme-2016-0077
    Language: English
    Publisher: Future Medicine Ltd
    Publication Date: 2016
    Location Call Number Limitation Availability
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    Online Resource
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