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  • Frontiers Media SA  (71)
  • 1
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    Table_4.docx
    Frontiers Media SA ; 2022
    In:  Frontiers in Veterinary Science Vol. 9 ( 2022-9-2)
    Details
    In: Frontiers in Veterinary Science, Frontiers Media SA, Vol. 9 ( 2022-9-2)
    Abstract: The Yangtze finless porpoise ( Neophocaena phocaenoides asiaeorientalis ) inhabiting the Yantze River, China is critically endangered because of the influences of infectious disease, human activity, and water contamination. Viral diseases are one of the crucial factors that threatening the health of Yangtze finless porpoise. However, there are few studies which elaborate the viral diversity of Yangtze finless. Therefore, this study was performed to investigate the viral diversity of Yangtze finless by metagenomics. Results indicated that a total of 12,686,252 high-quality valid sequences were acquired and 2,172 virus reads were recognized. Additionally, we also obtained a total of 10,600 contigs. Phages was the most abundant virus in the samples and the ratio of DNA and RNA viruses were 69.75 and 30.25%, respectively. Arenaviridae, Ackermannviridae and Siphoviridae were the three most predominant families in all the samples. Moreover, the majority of viral genus were Mammarenavirus, Limestonevirus and Lambdavirus . The results of gene prediction indicated that these viruses play vital roles in biological process, cellular component, molecular function, and disease. To the best of our knowledge, this is the first report on the viral diversity of Yangtze finless porpoise, which filled the gaps in its viral information. Meanwhile, this study can also provide a theoretical basis for the establishment of the prevention and protection system for virus disease of Yangtze finless porpoise.
    Type of Medium: Online Resource
    ISSN: 2297-1769
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    DOI: 10.3389/fvets.2022.922623
    DOI: 10.3389/fvets.2022.922623.s001
    DOI: 10.3389/fvets.2022.922623.s002
    DOI: 10.3389/fvets.2022.922623.s003
    DOI: 10.3389/fvets.2022.922623.s004
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2022
    detail.hit.zdb_id: 2834243-4
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  • 2
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    Functional Preservation and Reorganization of Brain during Motor Imagery in Patients with Incomplete Spinal Cord Injury: A Pilot fMRI Study
    Frontiers Media SA ; 2016
    In:  Frontiers in Human Neuroscience Vol. 10 ( 2016-02-15)
    Details
    In: Frontiers in Human Neuroscience, Frontiers Media SA, Vol. 10 ( 2016-02-15)
    Type of Medium: Online Resource
    ISSN: 1662-5161
    URL: Article
    DOI: 10.3389/fnhum.2016.00046
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2016
    detail.hit.zdb_id: 2425477-0
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  • 3
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    Table_1.DOCX
    Frontiers Media SA ; 2020
    In:  Frontiers in Human Neuroscience Vol. 14 ( 2020-12-2)
    Details
    In: Frontiers in Human Neuroscience, Frontiers Media SA, Vol. 14 ( 2020-12-2)
    Abstract: Background : Functional magnetic resonance imaging (fMRI) has been widely used to assess neural activity changes in gray matter (GM) in patients with multiple sclerosis (MS); however, brain function alterations in white matter (WM) relatively remain under-explored. Purpose : This work aims to identify the functional connectivity in both the WM and the GM of patients with MS using fMRI and the correlations between these functional changes and cumulative disability as well as the lesion ratio. Materials and Methods : For this retrospective study, 37 patients with clinically definite MS and 43 age-matched healthy controls were included between 2010 and 2014. Resting-state fMRI was performed. The WFU Pick and JHU Eve atlases were used to define 82 GM and 48 WM regions in common spaces, respectively. The time courses of blood oxygen level-dependent (BOLD) signals were averaged over each GM or WM region. The averaged time courses for each pair of GM and WM regions were correlated. All 82 × 48 correlations for each subject formed a functional correlation matrix. Results : Compared with the healthy controls, the MS patients had a decreased temporal correlation between the WM and the GM regions. Five WM bundles and four GM regions had significantly decreased mean correlation coefficients (CCs). More specifically, the WM functional alterations were negatively correlated with the lesion volume in the bilateral fornix, and the mean GM-averaged CCs of the WM bundles were inversely correlated with the lesion ratio ( r = −0.36, P = 0.012). No significant correlation was found between WM functional alterations and the paced auditory serial addition test score, Expanded Disease Severity Scale score, and Multiple Sclerosis Severity Score (MSSS) in MS. Conclusions : These findings highlight current gaps in our knowledge of the WM functional alterations in patients with MS and may link WM function with pathological mechanisms.
    Type of Medium: Online Resource
    ISSN: 1662-5161
    URL: Article
    URL: Article
    DOI: 10.3389/fnhum.2020.563048
    DOI: 10.3389/fnhum.2020.563048.s001
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2020
    detail.hit.zdb_id: 2425477-0
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  • 4
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    Table5.XLSX
    Frontiers Media SA ; 2021
    In:  Frontiers in Pharmacology Vol. 12 ( 2021-4-29)
    Details
    In: Frontiers in Pharmacology, Frontiers Media SA, Vol. 12 ( 2021-4-29)
    Abstract: Background: Platinum resistance poses a significant problem for oncology clinicians. As a result, the role of epigenetics and DNA methylation in platinum-based chemoresistance has gained increasing attention from researchers in recent years. A systematic investigation of aberrant methylation patterns related to platinum resistance across various cancer types is urgently needed. Methods: We analyzed the platinum chemotherapy response-related methylation patterns from different perspectives of 618 patients across 13 cancer types and integrated transcriptional and clinical data. Spearman’s test was used to evaluate the correlation between methylation and gene expression. Cox analysis, the Kaplan-Meier method, and log-rank tests were performed to identify potential risk biomarkers based on differentially methylated positions (DMPs) and compare survival based on DMP values. Support vector machines and receiver operating characteristic curves were used to identify the platinum-response predictive DMPs. Results: A total of 3,703 DMPs ( p value & lt; 0.001 and absolute delta beta & gt;0.10) were identified, and the DMP numbers of each cancer type varied. A total of 39.83% of DMPs were hypermethylated and 60.17% were hypomethylated in platinum-resistant patients. Among them, 405 DMPs (Benjamini and Hochberg adjusted p value & lt; 0.05) were found to be associated with prognosis in tumor patients treated with platinum-based regimens, and 664 DMPs displayed the potential to predict platinum chemotherapy response. In addition, we defined six DNA DMPs consisting of four gene members (mesothelin, protein kinase cAMP-dependent type II regulatory subunit beta, msh homeobox 1, and par-6 family cell polarity regulator alpha) that may have favorable prognostic and predictive values for platinum chemotherapy. Conclusion: The methylation-transcription axis exists and participates in the complex biological mechanism of platinum resistance in various cancers. Six DMPs and four associated genes may have the potential to serve as promising epigenetic biomarkers for platinum-based chemotherapy and guide clinical selection of optimal treatment.
    Type of Medium: Online Resource
    ISSN: 1663-9812
    URL: Article
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    DOI: 10.3389/fphar.2021.616529
    DOI: 10.3389/fphar.2021.616529.s001
    DOI: 10.3389/fphar.2021.616529.s002
    DOI: 10.3389/fphar.2021.616529.s003
    DOI: 10.3389/fphar.2021.616529.s004
    DOI: 10.3389/fphar.2021.616529.s005
    DOI: 10.3389/fphar.2021.616529.s006
    DOI: 10.3389/fphar.2021.616529.s007
    DOI: 10.3389/fphar.2021.616529.s008
    DOI: 10.3389/fphar.2021.616529.s009
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2021
    detail.hit.zdb_id: 2587355-6
    SSG: 15,3
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  • 5
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    New Burst-Oscillation Mode in Paced One-Dimensional Excitable Systems
    Frontiers Media SA ; 2022
    In:  Frontiers in Physiology Vol. 13 ( 2022-3-23)
    Details
    In: Frontiers in Physiology, Frontiers Media SA, Vol. 13 ( 2022-3-23)
    Abstract: A new type of burst-oscillation mode (BOM) is reported for the first time, by extensively investigating the response dynamics of a one-dimensional (1D) paced excitable system with unidirectional coupling. The BOM state is an alternating transition between two distinct phases, i.e., the phase with multiple short spikes and the phase with a long interval. The realizable region and the unrealizable region for the evolution of BOM are identified, which is determined by the initial pulse number in the system. It is revealed that, in the realizable region, the initial inhomogeneous BOM will eventually evolve to the homogeneously distributed spike-oscillation mode (SOM), while it can maintain in the unrealizable region. Furthermore, several dynamical features of BOM and SOM are theoretically predicted and have been verified in numerical simulations. The mechanisms of the emergence of BOM are discussed in detail. It is revealed that three key factors, i.e., the linking time, the system length, and the local dynamics, can effectively modulate the pattern of BOM. Moreover, the suitable parameter region of the external pacing ( A, f ) that can produce the new type of BOM, has been explicitly revealed. These results may facilitate a deeper understanding of bursts in nature and will have a useful impact in related fields.
    Type of Medium: Online Resource
    ISSN: 1664-042X
    URL: Article
    DOI: 10.3389/fphys.2022.854887
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2022
    detail.hit.zdb_id: 2564217-0
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  • 6
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    Image_2.PNG
    Frontiers Media SA ; 2022
    In:  Frontiers in Aging Neuroscience Vol. 14 ( 2022-5-19)
    Details
    In: Frontiers in Aging Neuroscience, Frontiers Media SA, Vol. 14 ( 2022-5-19)
    Abstract: In order to deeply understand the specific patterns of volume, microstructure, and functional changes in Multiple System Atrophy patients with cerebellar ataxia syndrome (MSA-c), we perform the current study by simultaneously applying structural (T1-weighted imaging), Diffusion tensor imaging (DTI), functional (BOLD fMRI) and extended Network-Based Statistics (extended-NBS) analysis. Twenty-nine MSA-c type patients and twenty-seven healthy controls (HCs) were involved in this study. First, we analyzed the whole brain changes of volume, microstructure, and functional connectivity (FC) in MSA-c patients. Then, we explored the correlations between significant multimodal MRI features and the total Unified Multiple System Atrophy Rating Scale (UMSARS) scores. Finally, we searched for sensitive imaging biomarkers for the diagnosis of MSA-c using support vector machine (SVM) classifier. Results showed significant grey matter atrophy in cerebellum and white matter microstructural abnormalities in cerebellum, left fusiform gyrus, right precentral gyrus and lingual gyrus. Extended-NBS analysis found two significant different connected components, featuring altered functional connectivity related to left and right cerebellar sub-regions, respectively. Moreover, the reduced fiber bundle counts at right Cerebellum_3 (Cbe3) and decreased fractional anisotropy (FA) values at bilateral Cbe9 were negatively associated with total UMSARS scores. Finally, the significant features at left Cbe9, Cbe1, and Cbe7b were found to be useful as sensitive biomarkers to differentiate MSA-c from HCs according to the SVM analysis. These findings advanced our understanding of the neural pathophysiological mechanisms of MSA from the perspective of multimodal neuroimaging.
    Type of Medium: Online Resource
    ISSN: 1663-4365
    URL: Article
    URL: Article
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    URL: Article
    DOI: 10.3389/fnagi.2022.799251
    DOI: 10.3389/fnagi.2022.799251.s001
    DOI: 10.3389/fnagi.2022.799251.s002
    DOI: 10.3389/fnagi.2022.799251.s003
    DOI: 10.3389/fnagi.2022.799251.s004
    DOI: 10.3389/fnagi.2022.799251.s005
    DOI: 10.3389/fnagi.2022.799251.s006
    DOI: 10.3389/fnagi.2022.799251.s007
    DOI: 10.3389/fnagi.2022.799251.s008
    DOI: 10.3389/fnagi.2022.799251.s009
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2022
    detail.hit.zdb_id: 2558898-9
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  • 7
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    Drainage Development in the Dunhuang Basin, NE Tibet, Controlled by Multi-Segment Fault Growth
    Frontiers Media SA ; 2021
    In:  Frontiers in Earth Science Vol. 9 ( 2021-12-9)
    Details
    In: Frontiers in Earth Science, Frontiers Media SA, Vol. 9 ( 2021-12-9)
    Abstract: The Dongbatu Shan (DBTS, also known as the Nanjie Shan), which interrupts the northern Tibetan foreland in the Dunhuang basin, is an active anticline. It has accommodated the northwestern growth of the eastern Altyn Tagh fault system (ATF). Although several thrust faults have been identified around the DBTS, their evolution history and influence on regional landscape have received little attention during the late-Quaternary. In this study, several geomorphic methods are used to investigate the interaction between drainage development and tectonic movement around DBTS. Based on high-resolution satellite images, field investigation, and cosmogenic nuclide 10 Be dating method, the fluvial landform sequences around DBTS were constructed. Using quantitative geomorphology methods including landscape relief profile, asymmetry factor (AF), and transverse topographic symmetry factor (T), we hypothesize that drainage deflection is controlled by multi-segment fault growth. Combining the results of the above-mentioned methods, we propose that Yulin He, flowing across the DBTS, had gone through several abandonments since the late mid-Pleistocene due to the lateral propagation of DBTS. Affected by the discharge of channel and multi-segment fault growth, our research confirms that the direction of river abandonment may have decoupled with the mountain range propagation trend. Based on the chronology dating, the DBTS has gone through two severe uplifts since ∼208 ka and the shortening rate across the central DBTS is constrained to be ∼1.47 mm/yr since ∼83 ka. Given the fact that thrust faults are widely developed around DBTS, we propose that the flower-like structure formed by the northward growth of the eastern ATF could better explain the development of the secondary subparallel faults.
    Type of Medium: Online Resource
    ISSN: 2296-6463
    URL: Article
    DOI: 10.3389/feart.2021.792504
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2021
    detail.hit.zdb_id: 2741235-0
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  • 8
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    Effective Expression of the Serratia marcescens Phospholipase A1 Gene in Escherichia coli BL21(DE3), Enzyme Characterization, and Crude Rapeseed Oil Degumming via a Free Enzyme Approach
    Frontiers Media SA ; 2019
    In:  Frontiers in Bioengineering and Biotechnology Vol. 7 ( 2019-10-17)
    Details
    In: Frontiers in Bioengineering and Biotechnology, Frontiers Media SA, Vol. 7 ( 2019-10-17)
    Type of Medium: Online Resource
    ISSN: 2296-4185
    URL: Article
    DOI: 10.3389/fbioe.2019.00272
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2019
    detail.hit.zdb_id: 2719493-0
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  • 9
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    DataSheet_2.docx
    Frontiers Media SA ; 2021
    In:  Frontiers in Oncology Vol. 11 ( 2021-10-13)
    Details
    In: Frontiers in Oncology, Frontiers Media SA, Vol. 11 ( 2021-10-13)
    Abstract: To evaluate the efficacy and safety of standard or low-dose chemotherapy followed by HLA-mismatched allogeneic T-cell infusion (allo-TLI) for the treatment of elderly patients with acute myeloid leukemia (AML) and patients with intermediate-2 to high-risk myelodysplastic syndrome (MDS). Methods We carried out a prospective, multicenter, single-arm clinical trial. Totally of 25 patients were enrolled, including 17 AML patients and 8 MDS patients. Each patient received four courses of non-ablative chemotherapy, with HLA-mismatched donor CD3 + allo-TLI 24 h after each course. AML patients received chemotherapy with decitabine, idarubicin, and cytarabine, and MDS patients received decitabine, cytarabine, aclarubicin, and granulocyte colony-stimulating factor. Results A total of 79 procedures were performed. The overall response rates of the AML and MDS patients were 94% and 75% and the 1-year overall survival rates were 88% (61–97%) and 60% (13–88%), respectively. The overall 60-day treatment-related mortality was 8%. Compared with a historical control cohort that received idarubicin plus cytarabine (3 + 7), the study group showed significantly better overall response (94% vs. 50%, P =0.002) and overall survival rates (the 1-year OS rate was 88% vs. 27%, P =0.014). Post-TLI cytokine-release syndrome (CRS) occurred after 79% of allo-TLI operations, and 96% of CRS reactions were grade 1. Conclusion Elderly AML patients and intermediate-2 to high-risk MDS patients are usually insensitive to or cannot tolerate regular chemotherapies, and may not have the opportunity to undergo allogeneic stem cell transplantation. Our study showed that non-ablative chemotherapy followed by HLA-mismatched allo-TLI is safe and effective, and may thus be used as a first-line treatment for these patients. Clinical Trial Registration https://www.chictr.org.cn/showproj.aspx?proj=20112 .
    Type of Medium: Online Resource
    ISSN: 2234-943X
    URL: Article
    URL: Article
    URL: Article
    DOI: 10.3389/fonc.2021.741341
    DOI: 10.3389/fonc.2021.741341.s001
    DOI: 10.3389/fonc.2021.741341.s002
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2021
    detail.hit.zdb_id: 2649216-7
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  • 10
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    Image_5.tif
    Frontiers Media SA ; 2022
    In:  Frontiers in Endocrinology Vol. 13 ( 2022-12-19)
    Details
    In: Frontiers in Endocrinology, Frontiers Media SA, Vol. 13 ( 2022-12-19)
    Abstract: Diabetic kidney disease (DKD) is one of the most prevalent complications of diabetes mellitus (DM) and is associated with gut microbial dysbiosis. We aim to build a diagnostic model to aid clinical practice and uncover a crucial harmful microbial community that contributes to DKD pathogenesis and exacerbation. Design A total of 528 fecal samples from 180 DKD patients and 348 non-DKD populations (138 DM and 210 healthy volunteers) from the First Affiliated Hospital of Zhengzhou University were recruited and randomly divided into a discovery phase and a validation phase. The gut microbial composition was compared using 16S rRNA sequencing. Then, the 180 DKD patients were stratified into four groups based on clinical stages and underwent gut microbiota analysis. We established DKD mouse models and a healthy fecal microbiota transplantation (FMT) model to validate the effects of gut microbiota on DKD and select the potential harmful microbial community. Untargeted metabolome–microbiome combined analysis of mouse models helps decipher the pathogenetic mechanism from a metabolic perspective. Results The diversity of the gut microbiome was significantly decreased in DKD patients when compared with that of the non-DKD population and was increased in the patients with more advanced DKD stages. The DKD severity in mice was relieved after healthy gut microbiota reconstruction. The common harmful microbial community was accumulated in the subjects with more severe DKD phenotypes (i.e., DKD and DKD5 patients and DKD mice). The harmful microbial community was positively associated with the serum injurious metabolites (e.g., cholic acid and hippuric acid). Conclusion The fecal microbial community was altered markedly in DKD. Combining the fecal analysis of both human and animal models selected the accumulated harmful pathogens. Partially recovering healthy gut microbiota can relieve DKD phenotypes via influencing pathogens’ effect on DKD mice’s metabolism.
    Type of Medium: Online Resource
    ISSN: 1664-2392
    URL: Article
    URL: Article
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    URL: Article
    DOI: 10.3389/fendo.2022.964389
    DOI: 10.3389/fendo.2022.964389.s001
    DOI: 10.3389/fendo.2022.964389.s002
    DOI: 10.3389/fendo.2022.964389.s003
    DOI: 10.3389/fendo.2022.964389.s004
    DOI: 10.3389/fendo.2022.964389.s005
    DOI: 10.3389/fendo.2022.964389.s006
    DOI: 10.3389/fendo.2022.964389.s007
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2022
    detail.hit.zdb_id: 2592084-4
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