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  • Frontiers Media SA  (24)
  • 1
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    Platycodon grandiflorus polysaccharides deeply participate in the anti-chronic bronchitis effects of platycodon grandiflorus decoction, a representative of “the lung and intestine are related”
    Frontiers Media SA ; 2022
    In:  Frontiers in Pharmacology Vol. 13 ( 2022-9-7)
    Details
    In: Frontiers in Pharmacology, Frontiers Media SA, Vol. 13 ( 2022-9-7)
    Abstract: Platycodon grandiflorus (Jacq.) A. DC. (PG) root is one of the most commonly used medicine-food materials for respiratory discomfort in Asia, usually in the form of a decoction or leaching solution. As everyone knows, both of decoction and leaching solution is a polyphase dispersion system, containing low-molecular-weight water-soluble active ingredients and hydrophilic macromolecules. This study aimed to discuss the synergistic effect of Platycodon grandiflorus polysaccharide (PGP) and platycodin D (PD) in PG decoction against chronic bronchitis (CB) and the mechanism underlying. A series of PGP, PD, and PGD + PD suspensions were administrated to CB model rats, on the levels of whole animal and in situ intestinal segment with or without mesenteric lymphatic vessels ligation. It exhibited that PGP exhibited synergistic effects with PD, on improving the histopathological abnormity, mucus secretion excess, and immunological imbalance in lung of CB model rat, closely associated with its modulations on the mucosal immunity status in small intestine. The polysaccharide macromolecules in PG decoction or leaching solution should be responsible for the modulation of pulmonary immune state, possibly through the common mucosal immune between small intestine and lung. These results might be a new perspective that illustrates the classical theory of “the lung and intestine are related” in traditional Chinese medicine.
    Type of Medium: Online Resource
    ISSN: 1663-9812
    URL: Article
    DOI: 10.3389/fphar.2022.927384
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2022
    detail.hit.zdb_id: 2587355-6
    SSG: 15,3
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  • 2
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    Table_1.docx
    Frontiers Media SA ; 2022
    In:  Frontiers in Immunology Vol. 13 ( 2022-7-8)
    Details
    In: Frontiers in Immunology, Frontiers Media SA, Vol. 13 ( 2022-7-8)
    Abstract: Coronary atherosclerotic heart disease (CAD) is a chronic inflammatory cardiovascular disease with high morbidity and mortality. Growing data indicate that many immune cells are involved in the development of atherosclerosis. However, the immunological roles of γδ T cells in the initiation and progression of CAD are not fully understood. Here, we used flow cytometry to determine phenotypical changes of γδ T cells and their subpopulations in peripheral blood samples collected from 37 CAD patients. The Pearson correlation coefficient was used to analyze the relationship between the clinical parameter (serum LDL-C level) and the changes of immunophenotypes of γδ T cells. Our results demonstrated that the frequencies and absolute numbers of total γδ T cells and Vδ2 + T cells were significantly decreased in CAD patients when compared to healthy individuals. However, the proportion of Vδ1 + T cells was much lower in CAD patients than that of healthy individuals. Most importantly, a significant alteration of the Vδ1/Vδ2 ratio was found in CAD patients. In addition, a series of surface markers that are associated with costimulatory signals (CD28, CD40L, CD80, CD86), activation levels (CD69, CD25, HLA-DR), activating NK cell receptors (NKp30, NKp46, NKG2D) and inhibitory receptors (PD-1, CTLA-4, PD-1, Tim-3) were determined and then analyzed in the total γδ T cells, Vδ2 + T cells and Vδ2 - T cells of CAD patients and healthy individuals. The data demonstrated that immunological activities of total γδ T cells, Vδ2 + T cells, and Vδ2 - T cells of CAD patients were much lower than those in healthy individuals. Moreover, we found that there were positive correlations between the serum LDL-C levels and frequencies of CD3 + γδ + T cells, CD69 + Vδ2 + T cells, NKG2D + Vδ2 + T cells, and NKp46 + Vδ2 + T cells. By contrast, there was an inverse correlation between the levels of serum LDL-C and the frequencies of CD69 + Vδ2 - T cells and NKp46 + Vδ2 - T cells. Accordingly, these findings could help us to better understand the roles of γδ T cells in the CAD, and shed light on the development of novel diagnostic techniques and therapeutic strategies by targeting γδ T cells for CAD patients.
    Type of Medium: Online Resource
    ISSN: 1664-3224
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    DOI: 10.3389/fimmu.2022.900334
    DOI: 10.3389/fimmu.2022.900334.s001
    DOI: 10.3389/fimmu.2022.900334.s002
    DOI: 10.3389/fimmu.2022.900334.s003
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2022
    detail.hit.zdb_id: 2606827-8
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  • 3
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    Table8.xls
    Frontiers Media SA ; 2022
    In:  Frontiers in Genetics Vol. 13 ( 2022-10-4)
    Details
    In: Frontiers in Genetics, Frontiers Media SA, Vol. 13 ( 2022-10-4)
    Abstract: Long non-coding RNAs (lncRNAs) have been extensively studied as important regulators of tumor development in various cancers. Tumor protein 53 target gene 1 (TP53TG1) is a newly identified lncRNA in recent years, and several studies have shown that TP53TG1 may play oncogenic or anti-oncogenic roles in different cancers. Nevertheless, the role of TP53TG1 in the development of cervical cancer is unclear. In our study, pan-cancer analysis showed that high expression of TP53TG1 was significantly associated with a better prognosis. We then constructed a TP53TG1 overexpression model in HeLa cell line to explore its functions and molecular targets. We found that TP53TG1 overexpression significantly inhibited cell proliferation and induced apoptosis, demonstrating that TP53TG1 may be a novel anti-oncogenic factor in cervical cancer. Furthermore, overexpression of TP53TG1 could activate type I interferon signaling pathways and inhibit the expression of genes involved in DNA damage responses. Meanwhile, TP53TG1 could affect alternative splicing of genes involved in cell proliferation or apoptosis by regulating the expression of many RNA-binding protein genes. Competing endogenous RNA (ceRNA) network analysis demonstrated that TP53TG1 could act as the sponge of several miRNAs to regulate the expression level of target genes. In conclusion, our study highlights the essential role of lncRNA TP53TG1 in the development of cervical cancer and suggests the potential regulatory mechanisms.
    Type of Medium: Online Resource
    ISSN: 1664-8021
    URL: Article
    URL: Article
    URL: Article
    URL: Article
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    DOI: 10.3389/fgene.2022.981030
    DOI: 10.3389/fgene.2022.981030.s001
    DOI: 10.3389/fgene.2022.981030.s002
    DOI: 10.3389/fgene.2022.981030.s003
    DOI: 10.3389/fgene.2022.981030.s004
    DOI: 10.3389/fgene.2022.981030.s005
    DOI: 10.3389/fgene.2022.981030.s006
    DOI: 10.3389/fgene.2022.981030.s007
    DOI: 10.3389/fgene.2022.981030.s008
    DOI: 10.3389/fgene.2022.981030.s009
    DOI: 10.3389/fgene.2022.981030.s010
    DOI: 10.3389/fgene.2022.981030.s011
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2022
    detail.hit.zdb_id: 2606823-0
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  • 4
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    Data_Sheet_1.xlsx
    Frontiers Media SA ; 2022
    In:  Frontiers in Plant Science Vol. 13 ( 2022-5-11)
    Details
    In: Frontiers in Plant Science, Frontiers Media SA, Vol. 13 ( 2022-5-11)
    Abstract: Crop biofortification with inorganic selenium (Se) fertilizer is a feasible strategy to improve the health of residents in Se-deficient areas. For eco-friendly crop Se biofortification, a comprehensive understanding of the effects of Se on crop and soil nematodes is vital. In this study, a rice pot experiment was carried out to test how selenite supply (untreated control (0), 5, 10, 15, 20, 25, 30, 35, 40, 45, 50, 100, or 200 mg Se kg −1 ) in soil affected rice growth, rice Se accumulation, and soil nematode abundance and composition. The results showed that selenite supply (5–200 mg kg −1 ) generally increased the number of rice tillers, rice yield, and Se concentrations in rice grains. In soil under 10 mg kg −1 Se treatment, the genus composition of nematodes changed significantly compared with that in the control soil. With increased Se level ( & gt; 10 mg kg −1 ), soil nematode abundance decreased significantly. Correlation analysis also demonstrated the positive relationships between soil Se concentrations (total Se and bioavailable Se) with rice plant parameters (number of rice tillers, rice yield, and grain Se concentration) and negative relationships between soil Se concentrations (total Se and bioavailable Se) with soil nematode indexes (nematode abundance and relative abundance of Tobrilus ). This study provides insight into balancing Se biofortification of rice and soil nematode community protection and suggests the effective concentrations for total Se (1.45 mg kg −1 ) and bioavailable Se (0.21 mg kg −1 ) to soil nematode abundances at 20% level (EC20) as soil Se thresholds. At Se concentrations below these thresholds, rice plant growth and Se accumulation in the grain will still be promoted, but the disturbance of the soil nematodes would be negligible.
    Type of Medium: Online Resource
    ISSN: 1664-462X
    URL: Article
    URL: Article
    DOI: 10.3389/fpls.2022.889459
    DOI: 10.3389/fpls.2022.889459.s001
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2022
    detail.hit.zdb_id: 2687947-5
    detail.hit.zdb_id: 2613694-6
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  • 5
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    Table_6.xlsx
    Frontiers Media SA ; 2022
    In:  Frontiers in Endocrinology Vol. 13 ( 2022-6-1)
    Details
    In: Frontiers in Endocrinology, Frontiers Media SA, Vol. 13 ( 2022-6-1)
    Abstract: Diabetes-associated cognitive decline (DCD), is one of the complications of diabetes, which is characterized by a series of neurophysiological and pathological abnormalities. However, the exact pathogenesis of DCD is still unknown. Single-cell RNA sequencing (scRNA-seq) could discover unusual subpopulations, explore functional heterogeneity and identify signaling pathways and potential markers. The aim of this research was to provide deeper opinion into molecular and cellular changes underlying DCD, identify different cellular types of the diabetic mice hippocampus at single-cell level, and elucidate the factors mediating the pathogenesis of DCD. To elucidate cell specific gene expression changes in the hippocampus of diabetic encephalopathy. Single-cell RNA sequencing of hippocampus from db/m and db/db mice was carried out. Subclustering analysis was performed to further describe microglial cell subpopulations. Interestingly using immunohistochemistry, these findings were confirmed at the protein level. Single cell analysis yielded transcriptome data for 14621 hippocampal cells and defined 11 different cell types. Analysis of differentially expressed genes in the microglia compartments indicated that infection- and immune system process- associated terms, oxidative stress and inflammation play vital roles in the progression of DCD. Compared with db/m mouse, experiments at the protein level supported the activation of microglia, increased expression of inflammatory factors and oxidative stress damage in the hippocampus of db/db mouse. In addition, a major finding of our research was the subpopulation of microglia that express genes related to pro-inflammatory disease-associated microglia (DAM). Our research reveals pathological alterations of inflammation and oxidative stress mediated hippocampal damage in the db/db mice, and may provide potential diagnostic biomarkers and therapeutic interventions for DCD.
    Type of Medium: Online Resource
    ISSN: 1664-2392
    URL: Article
    URL: Article
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    DOI: 10.3389/fendo.2022.891039
    DOI: 10.3389/fendo.2022.891039.s001
    DOI: 10.3389/fendo.2022.891039.s002
    DOI: 10.3389/fendo.2022.891039.s003
    DOI: 10.3389/fendo.2022.891039.s004
    DOI: 10.3389/fendo.2022.891039.s005
    DOI: 10.3389/fendo.2022.891039.s006
    DOI: 10.3389/fendo.2022.891039.s007
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2022
    detail.hit.zdb_id: 2592084-4
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  • 6
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    DataSheet_3.pdf
    Frontiers Media SA ; 2019
    In:  Frontiers in Genetics Vol. 10 ( 2019-12-17)
    Details
    In: Frontiers in Genetics, Frontiers Media SA, Vol. 10 ( 2019-12-17)
    Type of Medium: Online Resource
    ISSN: 1664-8021
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    DOI: 10.3389/fgene.2019.01255
    DOI: 10.3389/fgene.2019.01255.s001
    DOI: 10.3389/fgene.2019.01255.s002
    DOI: 10.3389/fgene.2019.01255.s003
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2019
    detail.hit.zdb_id: 2606823-0
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  • 7
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    Data_Sheet_1.docx
    Frontiers Media SA ; 2022
    In:  Frontiers in Cardiovascular Medicine Vol. 9 ( 2022-4-18)
    Details
    In: Frontiers in Cardiovascular Medicine, Frontiers Media SA, Vol. 9 ( 2022-4-18)
    Abstract: Using a newly released National Health and Nutrition Examination Survey (NHANES) data of serum Klotho, this study aimed to explore the relationship between Klotho and specific cardiovascular diseases (CVD), as well as the mediation effect of renal function, among middle-aged and older individuals within the general population. Methods This nationally representative cross-sectional study analyzed data from the 2007–2016 NHANES. A total of 13,765 participants, who aged 40 years or older, from the general population were examined. Klotho were divided into four groups based on median and interquartile range. The associations among Klotho (exposure), congestive heart failure (CHF; outcome), and renal function markers [estimated glomerular filtration rate (eGFR), blood urea nitrogen (BUN), uric acid (UA), and urine albumin-to-creatinine ratio (UACR); mediators] were investigated using mediation analysis. Results In comparison to the lowest quartile, Klotho in the highest quartile was independently associated with the prevalence of CHF (OR 0.59; 95% CI 0.46–0.77, p for trend = 0.001), but not with other individual CVDs. Klotho had a significant direct effect on the prevalence of CHF (all p & lt; 0.001), while eGFR, BUN, UA, and UACR partly mediated the indirect effect of Klotho on the prevalence of CHF (all p & lt; 0.05), explaining 19.51, 6.98, 13.93, and 0.71% of the association between Klotho and CHF, respectively. Additionally, restricted cubic spline regression demonstrated a linear association and negative correlation between Klotho level and CHF. Conclusion These findings suggest that Klotho is closely linked to CHF and renal function may be a key mediator of this association.
    Type of Medium: Online Resource
    ISSN: 2297-055X
    URL: Article
    URL: Article
    DOI: 10.3389/fcvm.2022.802287
    DOI: 10.3389/fcvm.2022.802287.s001
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2022
    detail.hit.zdb_id: 2781496-8
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  • 8
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    4D Printing of Lead Zirconate Titanate Piezoelectric Composites Transducer Based on Direct Ink Writing
    Frontiers Media SA ; 2021
    In:  Frontiers in Materials Vol. 8 ( 2021-5-28)
    Details
    In: Frontiers in Materials, Frontiers Media SA, Vol. 8 ( 2021-5-28)
    Abstract: Lead zirconate titanate (PZT) piezoelectric composites used in transducers were fabricated via direct ink writing (DIW) combined with furnace sintering and resin impregnation. A ceramic slurry with a volume fraction of 52 vol% and suitable viscoelasticity was prepared. After post-process, the PZT ceramic specimens showed a nanoscale grain size with a density of 7.63 g/cm 3 , accounting for 97.8% of the theoretical density. The effects of different printing rod spacing on the electrical properties of composites were evaluated and lucubrated. Finally, an underwater acoustic transducer was assembled by using the PZT piezoelectric composites fabricated by the above method. The electrical signal generated by the underwater acoustic transducer changed autonomously with the acoustic stimulation, which indicated the application mode of 4D printing in functional devices in the future.
    Type of Medium: Online Resource
    ISSN: 2296-8016
    URL: Article
    DOI: 10.3389/fmats.2021.659441
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2021
    detail.hit.zdb_id: 2759394-0
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  • 9
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    Prediction of Radiation Pneumonitis Using Genome-Scale Flux Analysis of RNA-Seq Derived From Peripheral Blood
    Frontiers Media SA ; 2021
    In:  Frontiers in Medicine Vol. 8 ( 2021-8-31)
    Details
    In: Frontiers in Medicine, Frontiers Media SA, Vol. 8 ( 2021-8-31)
    Abstract: Purpose: Radiation pneumonitis (RP) frequently occurs during a treatment course of chest radiotherapy, which significantly reduces the clinical outcome and efficacy of radiotherapy. The ability to easily predict RP before radiotherapy would allow this disease to be avoided. Methods and Materials: This study recruited 48 lung cancer patients requiring chest radiotherapy. For each participant, RNA sequencing (RNA-Seq) was performed on a peripheral blood sample before radiotherapy. The RNA-Seq data was then integrated into a genome-scale flux analysis to develop an RP scoring system for predicting the probability of occurrence of RP. Meanwhile, the clinical information and radiation dosimetric parameters of this cohort were collected for analysis of any statistical associations between these parameters and RP. A non-parametric rank sum test showed no significant difference between the predicted results from the RP score system and the clinically observed occurrence of RP in this cohort. Results: The results of the univariant analysis suggested that the tumor stage, exposure dose, and bilateral lung dose of V5 and V20 were significantly associated with the occurrence of RP. The results of the multivariant analysis suggested that the exposure doses of V5 and V20 were independent risk factors associated with RP and a level of RP ≥ 2, respectively. Thus, our results indicate that our RP scoring system could be applied to accurately predict the risk of RP before radiotherapy because the scores were highly consistent with the clinically observed occurrence of RP. Conclusion: Compared with the standard statistical methods, this genome-scale flux-based scoring system is more accurate, straightforward, and economical, and could therefore be of great significance when making clinical decisions for chest radiotherapy.
    Type of Medium: Online Resource
    ISSN: 2296-858X
    URL: Article
    DOI: 10.3389/fmed.2021.715961
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2021
    detail.hit.zdb_id: 2775999-4
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  • 10
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    Multi-Scale Pore Structure Characterization of Silurian Marine Shale and Its Coupling Relationship With Material Composition: A Case Study in the Northern Guizhou Area
    Frontiers Media SA ; 2022
    In:  Frontiers in Earth Science Vol. 10 ( 2022-7-11)
    Details
    In: Frontiers in Earth Science, Frontiers Media SA, Vol. 10 ( 2022-7-11)
    Abstract: Investigation of pore structure is vital for shale reservoir evaluation and also “sweet spot” prediction. As the strong heterogeneity in pore types, morphology, and size distributions of organic matter-rich shales, it is essential to combine different approaches to comprehensively characterize them.Field emission-scanning electron microscopy (FE-SEM), low-pressure gas (CO2 and N2) adsorption, and high-pressure mercury intrusion (HPMI) were employed to systematically investigate the pore structure of the lower Longmaxi shale reservoirs in the northern Guizhou area. The results show that the shales can be divided into four lithofacies based on mineral composition, namely, siliceous shale (SS), clay shale (CS), carbonate shale (CAS), and mixed shale (MS), among which siliceous shale is the primary lithofacies of the Longmaxi shale. Numerous organic matter (OM)-hosted pores, clay interlayer pores, interparticle pores, and intraparticle pores were identified within shale reservoirs. The specific surface area ranges from 11.3 to 27.4 m 2 /g, with an average of 18.1 m 2 /g. It exhibits a strong positive correlation with TOC contents, suggesting that organic matter is the major contributor to the specific surface areas. A wide range of pore size distribution was measured by integration of gas adsorption and HPMI. It is shown that the pore size is primarily distributed within ∼100 nm, corresponding to micropores, mesopores, and part of macropores. The total pore volume, which is mostly derived from the contribution of micropores and mesopores, remains within a range of 0.11 to 0.025 ml/g, with an average of 0.018 ml/g. Furthermore, the volume of micropores and mesopores is mainly controlled by organic matter contents. The dissolution pore contributes most to the macropore space within shale reservoirs, based on the positive correlation with macropore volume and easily dissolved minerals, including carbonate and feldspar. Also, the total pores volume is mainly dominated by organic matter and carbonate contents. This is possibly attributed to the easily dissolved and rigid features of carbonate, which can protect the primary interparticle pores due to its high compression resistance and is conducive to forming abundant dissolution pores. OM-rich carbonate-bearing mixed shale may be the most favorable lithofacies for gas storage in the northern Guizhou area.
    Type of Medium: Online Resource
    ISSN: 2296-6463
    URL: Article
    DOI: 10.3389/feart.2022.930650
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2022
    detail.hit.zdb_id: 2741235-0
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