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  • Frontiers Media SA  (3)
  • 1
    Online Resource
    Online Resource
    Frontiers Media SA ; 2022
    In:  Frontiers in Earth Science Vol. 10 ( 2022-5-10)
    In: Frontiers in Earth Science, Frontiers Media SA, Vol. 10 ( 2022-5-10)
    Abstract: The Tibetan Plateau suffers from various types of geohazards (collapses, landslides, and debris flows.) due to abrupt changes in complex topography and weather conditions. Global warming and frequent high-intensity earthquakes in recent years have exacerbated the situation. Collapses and landslides provide vast amount of soil and debris which are conveyed downstream by runoff caused by extreme rainfalls to form large-scale debris flows; then, the debris flows block rivers and finally form dam-break floods, that is, a hazard chain triggered by debris flows. Along the evolution direction of the hazard chain, the affected areas are constantly amplified. This study first summarizes the related research studies on river blockage, debris-flow dam failure, and the hazard chain triggered by debris flows and then points out the drawbacks of existing research studies. Overall, the research (including mechanism, risk assessment, key prevention, and control technologies) on the hazard chain triggered by debris flows is still in its infancy and is disconnected among single hazard types in the hazard chain; meanwhile, the understanding of the mechanism of debris flow blocking the river is not enough; the established model and discriminant have minimal application scope, and there is no empirical model and dynamic model of debris-flow dam failure. Finally, several key scientific issues of this field were raised: 1) it is necessary to elaborate the coupling mechanism of debris-flow dam formation and construct the discriminant and numerical model of debris flow blocking the river with high precision and a wide application range. 2) It is necessary to further study the failure mechanism of a debris-flow dam, construct the numerical model of the failure process of a debris-flow dam, and accurately simulate the outburst flood hydrograph. 3) It is necessary to clarify the critical transformation conditions and dynamic evolution process of the hazard chain caused by debris flows, complete the accurate quantitative simulation of the whole disaster chain process, then establish a complete risk assessment system of the hazard chain, and finally develop some key prevention and control technologies suitable for the hazard chain.
    Type of Medium: Online Resource
    ISSN: 2296-6463
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2022
    detail.hit.zdb_id: 2741235-0
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  • 2
    In: Frontiers in Physics, Frontiers Media SA, Vol. 10 ( 2022-3-29)
    Abstract: We demonstrate an ultrafast humidity micro-fiber sensor based on molybdenum disulfide (MoS 2 ) cladding with three dimensional network structure. The high surface-to-volume rations and porous mesh structure improve the interaction of between MoS 2 and water molecules, further enhancing the performance of the humidity sensor. The results demonstrated that the sensor can perform in a wide relative humidity (RH) range between 10%RH to 90%RH with rapid dynamic behavior (response and recovery time are 0.090 and 0.130 s respectively). The sum of response and recovery time (total time) is 0.220 s, which is the fastest in the reported MoS 2 -based humidity sensors. The sensitivity of this sensor is up to -1.501 dB/%RH in the RH range (77%RH–90%RH). Such a high performance RH sensor will have a wide range of application potential in chemical processing, various medical diagnostics, and so on.
    Type of Medium: Online Resource
    ISSN: 2296-424X
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2022
    detail.hit.zdb_id: 2721033-9
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  • 3
    Online Resource
    Online Resource
    Frontiers Media SA ; 2024
    In:  Frontiers in RNA Research Vol. 2 ( 2024-4-3)
    In: Frontiers in RNA Research, Frontiers Media SA, Vol. 2 ( 2024-4-3)
    Abstract: Ribosome biogenesis is essential for cell growth, proliferation, and animal development. Its deregulation leads to various human disorders such as ribosomopathies and cancer. Thus, tight regulation of ribosome biogenesis is crucial for normal cell homeostasis. Emerging evidence suggests that posttranslational modifications such as ubiquitination and SUMOylation play a crucial role in regulating ribosome biogenesis. Our recent studies reveal that USP36, a nucleolar deubiquitinating enzyme (DUB), acts also as a SUMO ligase to regulate nucleolar protein group SUMOylation, thereby being essential for ribosome biogenesis. Here, we provide an overview of the current understanding of the SUMOylation regulation of ribosome biogenesis and discuss the role of USP36 in nucleolar SUMOylation.
    Type of Medium: Online Resource
    ISSN: 2813-7116
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2024
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