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  • Frontiers Media SA  (7)
  • 1
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    Image_2.tif
    Frontiers Media SA ; 2023
    In:  Frontiers in Neurology Vol. 14 ( 2023-2-21)
    Details
    In: Frontiers in Neurology, Frontiers Media SA, Vol. 14 ( 2023-2-21)
    Abstract: To understand the varieties, evaluation, treatment, and prognosis of severe neurological diseases using the third NCU survey in China. Design A cross-sectional questionnaire study. The study was completed in three main steps: filling in the questionnaire, sorting out the survey data, and analyzing the survey data. Results Of 206 NCUs, 165 (80%) provided relatively complete information. It was estimated that 96,201 patients with severe neurological diseases were diagnosed and treated throughout the year, with an average fatality rate of 4.1%. The most prevalent severe neurological disease was cerebrovascular disease (55.2%). The most prevalent comorbidity was hypertension (56.7%). The most prevalent complication was hypoproteinemia (24.2%). The most common nosocomial infection was hospital-acquired pneumonia (10.6%). The GCS, APACHE II, EEG, and TCD were the most commonly used (62.4–95.2%). The implementation rate of the five nursing evaluation techniques reached 55.8–90.9%. Routinely raising the head of the bed by 30°, endotracheal intubation and central venous catheterization were the mostprevalent treatment strategies (97.6, 94.5, and 90.3%, respectively). Traditional tracheotomy, invasive mechanical ventilation and nasogastric tube feeding (75.8, 95.8, and 95.8%, respectively) were more common than percutaneous tracheotomy, non-invasive mechanical ventilation and nasogastric tube insertion (57.6, 57.6, and 66.7%, respectively). Body surface hypothermia brain protection technology was more commonly used than intravascular hypothermia technology (67.3 & gt; 6.1%). The rates of minimally invasive hematoma removal and ventricular puncture were only 40.0 and 45.5%, respectively. Conclusion In addition to traditional recognized basic life assessment and support technology, it is necessary to the use of promote specialized technology for neurological diseases, according to the characteristics of critical neurological diseases.
    Type of Medium: Online Resource
    ISSN: 1664-2295
    URL: Article
    URL: Article
    URL: Article
    DOI: 10.3389/fneur.2023.1114204
    DOI: 10.3389/fneur.2023.1114204.s001
    DOI: 10.3389/fneur.2023.1114204.s002
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2023
    detail.hit.zdb_id: 2564214-5
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  • 2
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    Data_Sheet_1.ZIP
    Frontiers Media SA ; 2020
    In:  Frontiers in Veterinary Science Vol. 7 ( 2020-12-3)
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    In: Frontiers in Veterinary Science, Frontiers Media SA, Vol. 7 ( 2020-12-3)
    Abstract: Avian-origin H3N2 canine influenza viruses (CIVs) cause severe contagious respiratory disease in dogs, and quickly adapt to new environments. To further understand the mechanism of virus infection and host-virus interactions, we characterized the complete phosphoproteome of dogs infected with H3N2 CIV. Nine-week-old Beagle dogs were inoculated intranasally with 10 6 EID 50 of A/canine/Guangdong/04/2014 (H3N2) virus. Lung sections were harvested at 5 days post-inoculation (dpi) and processed for global and quantitative analysis of differentially expressed phosphoproteins. A total of 1,235 differentially expressed phosphorylated proteins were identified in the dog lung after H3N2 CIV infection, and 3,016 modification sites were identified among all differentially expressed proteins. We then performed an enrichment analysis of functional annotations using Kyoto Encyclopedia of Genes and Genomes (KEGG) and gene ontology (GO) database analyses to predict the functions of the identified differential phosphoproteins. Our data indicate that H3N2 CIV infection causes dramatic changes in the host protein phosphorylation of dog lungs. To our knowledge, this is the first study to assess the effect of H3N2 CIV infection on the phosphoproteome of beagles. These data provide novel insights into H3N2-CIV-triggered regulatory phosphorylation circuits and signaling networks and may improve our understanding of the mechanisms underlying CIV pathogenesis in dogs.
    Type of Medium: Online Resource
    ISSN: 2297-1769
    URL: Article
    URL: Article
    DOI: 10.3389/fvets.2020.585071
    DOI: 10.3389/fvets.2020.585071.s001
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2020
    detail.hit.zdb_id: 2834243-4
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  • 3
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    Table_3.docx
    Frontiers Media SA ; 2022
    In:  Frontiers in Cardiovascular Medicine Vol. 9 ( 2022-2-15)
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    In: Frontiers in Cardiovascular Medicine, Frontiers Media SA, Vol. 9 ( 2022-2-15)
    Abstract: There are conflicting data concerning the prognostic significance of syncope in acute pulmonary embolism (PE). This study aimed to investigate the impact of syncope on clinical outcomes of acute PE, and determine the clinical phenotypes of PE patients with syncope and their correlation with prognosis. Methods In the ongoing, national, multicenter, registry study, the China pUlmonary thromboembolism REgistry Study (CURES) enrolling consecutive patients with acute PE, patients with and without syncope were investigated. Principal component analysis (PCA) was performed using nine variables relevant to syncope and PE, including age, sex, body mass index, history of cardiovascular disease, recent surgery or trauma, malignancy, pulse, systolic blood pressure, and respiratory rate. Patient classification was performed using cluster analysis based on the PCA-transformed data. The clinical presentation, disease severity and outcomes were compared among the phenotypes. Results In 7,438 patients with acute PE, 777 (10.4%) had syncope, with younger age, more females and higher body mass index. Patients with syncope had higher frequency of precordial pain, palpitation, and elevated cardiac biomarkers, as well as higher D-Dimer level. In the syncope group, more patients had right ventricular/left ventricular ratio & gt; 0.9 in ultrasonic cardiogram and these patients had higher estimated pulmonary arterial systolic pressure compared with patients without syncope. As the initial antithrombotic treatment, more patients with syncope received systemic thrombolysis. Despite a higher prevalence of hemodynamic instability (OR 7.626, 95% CI 2.960–19.644, P & lt; 0.001), syncope did not increase in-hospital death. Principal component analysis revealed that four independent components accounted for 60.3% of variance. PE patients with syncope were classified into four phenotypes, in which patients with high pulse and respiratory rate had markedly higher all-cause mortality during admission. Conclusion Syncope was associated with hemodynamic instability and more application of thrombolysis, without increasing in-hospital deaths. Different clinical phenotypes existed in PE patients with syncope, which might be caused by various mechanisms and thus correlated with clinical outcomes.
    Type of Medium: Online Resource
    ISSN: 2297-055X
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    DOI: 10.3389/fcvm.2022.836850
    DOI: 10.3389/fcvm.2022.836850.s001
    DOI: 10.3389/fcvm.2022.836850.s002
    DOI: 10.3389/fcvm.2022.836850.s003
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2022
    detail.hit.zdb_id: 2781496-8
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  • 4
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    Table_1.XLSX
    Frontiers Media SA ; 2020
    In:  Frontiers in Earth Science Vol. 8 ( 2020-9-16)
    Details
    In: Frontiers in Earth Science, Frontiers Media SA, Vol. 8 ( 2020-9-16)
    Type of Medium: Online Resource
    ISSN: 2296-6463
    URL: Article
    URL: Article
    DOI: 10.3389/feart.2020.00367
    DOI: 10.3389/feart.2020.00367.s001
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2020
    detail.hit.zdb_id: 2741235-0
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  • 5
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    An Eco-Friendly Phosphogypsum-Based Cementitious Material: Performance Optimization and Enhancing Mechanisms
    Frontiers Media SA ; 2022
    In:  Frontiers in Physics Vol. 10 ( 2022-5-10)
    Details
    In: Frontiers in Physics, Frontiers Media SA, Vol. 10 ( 2022-5-10)
    Abstract: Little published data were effective in decreasing the setting time and improving the strength development of phosphogypsum-based supersulfate cement (P-SSC) containing an excess of 40% phosphogypsum to achieve adequate field working and mechanical properties. This study aimed to optimize the application performance of P-SSC by wet grinding, the enhancement mechanism of which was discussed further. The wet grinding mainly refined and dispersed the phosphogypsum with the large particle size, improving the formation of ettringite by increasing the supersaturation of phosphogypsum. However, the release of impurities prolonged the setting time of P-SSC pastes, leading to a lower early strength. Short-time wet grinding destroyed the surface structure of slag with the small particle size, presenting a higher hydration degree. It seemed to have a more significant improvement of generated C-(A)-S-H gel, while treating P-SSC by wet grinding slightly enhanced strength development. Increasing the aluminate concentration by incorporating active aluminum phases in this process significantly promoted the generation rate of ettringite and weakened the negative effect of impurity release. Therefore, a feasible and effective method to prepare P-SSC pastes was proposed to realize the large-scale application of phosphogypsum in the building materials industry.
    Type of Medium: Online Resource
    ISSN: 2296-424X
    URL: Article
    DOI: 10.3389/fphy.2022.892037
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2022
    detail.hit.zdb_id: 2721033-9
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  • 6
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    Table1.XLSX
    Frontiers Media SA ; 2023
    In:  Frontiers in Environmental Science Vol. 10 ( 2023-1-11)
    Details
    In: Frontiers in Environmental Science, Frontiers Media SA, Vol. 10 ( 2023-1-11)
    Abstract: Soil salinity is well known heterogeneous and various within natural soil environment. In Songnen grassland of Northeast China, grazing aggravates the saline-alkali heterogeneity in soil habitat, which led to dominant clonal plant species forming a variety of adaptive strategies. However, based on the previous studies of morphological plasticity and clonal integration in clonal plants, there was a lack of mechanism research on the spatial expansion strategy of clonal plants population subjected to clipping in saline-alkali heterogeneity soil patches. To address this knowledge gap, we carried out an experiment by applying different clipping intensities (0%, 35%, 70% of the above-ground biomass removed) to explore the spatial expansion strategy and morphological plasticity of Leymus chinensis and their belowground rhizomes in different heterogeneous saline-alkali patches. We found that, clipping significantly decreased the plant average height and above-ground biomass in homogeneous patches, especially heavy clipping had a significant adverse impact on plant belowground (rhizome, fine root) biomass and leaf area. However, there was no significant difference in the biomass, average height, and leaf area among the clipping treatments in low saline-alkali heterogeneous patches. In addition, the number of leaves, daughter plants and rhizome internode buds were significantly affected by saline-alkali heterogeneity alone, and low saline-alkali heterogeneity had a positive effect on these parameters. Biomass accumulation and rhizome expansion were gradually inhibited by the increasing of clipping intensity in a homogeneous environment, but the inhibitory effect of clipping was not significant in saline-alkali patches soil. We concluded that L. chinensis can respond to grazing or mowing disturbance by increasing tiller and daughter-plant numbers in a saline-alkali heterogeneous environment. The saline-alkali patches promoted clonal plant population spatial expansion more than grazing or mowing disturbance did. This study emphasizes saline-alkali heterogeneity distribution patterns in grassland soil environment were the primary and important driving factor promoting the spatial expansion of L. chinensis .
    Type of Medium: Online Resource
    ISSN: 2296-665X
    URL: Article
    URL: Article
    URL: Article
    DOI: 10.3389/fenvs.2022.1106825
    DOI: 10.3389/fenvs.2022.1106825.s001
    DOI: 10.3389/fenvs.2022.1106825.s002
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2023
    detail.hit.zdb_id: 2741535-1
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  • 7
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    Table_1.xlsx
    Frontiers Media SA ; 2021
    In:  Frontiers in Neuroscience Vol. 15 ( 2021-12-9)
    Details
    In: Frontiers in Neuroscience, Frontiers Media SA, Vol. 15 ( 2021-12-9)
    Abstract: Background: Neurodegenerative diseases (NDDs) are the leading cause of disability worldwide while their metabolic pathogenesis is unclear. Genome-wide association studies (GWASs) offer an unprecedented opportunity to untangle the relationship between metabolites and NDDs. Methods: By leveraging two-sample Mendelian randomization (MR) approaches and relying on GWASs summary statistics, we here explore the causal association between 486 metabolites and five NDDs including Alzheimer’s Disease (AD), amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), Parkinson’s disease (PD), and multiple sclerosis (MS). We validated our MR results with extensive sensitive analyses including MR-PRESSO and MR-Egger regression. We also performed linkage disequilibrium score regression (LDSC) and colocalization analyses to distinguish causal metabolite-NDD associations from genetic correlation and LD confounding of shared causal genetic variants. Finally, a metabolic pathway analysis was further conducted to identify potential metabolite pathways. Results: We detected 164 metabolites which were suggestively associated with the risk of NDDs. Particularly, 2-methoxyacetaminophen sulfate substantially affected ALS (OR = 0.971, 95%CIs: 0.961 ∼ 0.982, FDR = 1.04E-4) and FTD (OR = 0.924, 95%CIs: 0.885 ∼ 0.964, FDR = 0.048), and X-11529 (OR = 1.604, 95%CIs: 1.250 ∼ 2.059, FDR = 0.048) and X-13429 (OR = 2.284, 95%CIs: 1.457 ∼ 3.581, FDR = 0.048) significantly impacted FTD. These associations were further confirmed by the weighted median and maximum likelihood methods, with MR-PRESSO and the MR-Egger regression removing the possibility of pleiotropy. We also observed that ALS or FTD can alter the metabolite levels, including ALS and FTD on 2-methoxyacetaminophen sulfate. The LDSC and colocalization analyses showed that none of the identified associations could be driven by genetic correlation or confounding by LD with common causal loci. Multiple metabolic pathways were found to be involved in NDDs, such as “urea cycle” ( P = 0.036), “arginine biosynthesis” ( P = 0.004) on AD and “phenylalanine, tyrosine and tryptophan biosynthesis” ( P = 0.046) on ALS. Conclusion: our study reveals robust bidirectional causal associations between servaral metabolites and neurodegenerative diseases, and provides a novel insight into metabolic mechanism for pathogenesis and therapeutic strategies of these diseases.
    Type of Medium: Online Resource
    ISSN: 1662-453X
    URL: Article
    URL: Article
    URL: Article
    DOI: 10.3389/fnins.2021.680104
    DOI: 10.3389/fnins.2021.680104.s001
    DOI: 10.3389/fnins.2021.680104.s002
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2021
    detail.hit.zdb_id: 2411902-7
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