In:
Frontiers in Cellular Neuroscience, Frontiers Media SA, Vol. 17 ( 2023-7-20)
Abstract:
Inhibitory γ-aminobutyric acid (GABA)-ergic interneurons mediate inhibition in neuronal circuitry and support normal brain function. Consequently, dysregulation of inhibition is implicated in various brain disorders. Parvalbumin (PV) and somatostatin (SST) interneurons, the two major types of GABAergic inhibitory interneurons in the hippocampus, exhibit distinct morpho-physiological properties and coordinate information processing and memory formation. However, the molecular mechanisms underlying the specialized properties of PV and SST interneurons remain unclear. This study aimed to compare the transcriptomic differences between these two classes of interneurons in the hippocampus using the ribosome tagging approach. The results revealed distinct expressions of genes such as voltage-gated ion channels and GABA A receptor subunits between PV and SST interneurons. Gabrd and Gabra6 were identified as contributors to the contrasting tonic GABAergic inhibition observed in PV and SST interneurons. Moreover, some of the differentially expressed genes were associated with schizophrenia and epilepsy. In conclusion, our results provide molecular insights into the distinct roles of PV and SST interneurons in health and disease.
Type of Medium:
Online Resource
ISSN:
1662-5102
DOI:
10.3389/fncel.2023.1146278
DOI:
10.3389/fncel.2023.1146278.s001
DOI:
10.3389/fncel.2023.1146278.s002
DOI:
10.3389/fncel.2023.1146278.s003
DOI:
10.3389/fncel.2023.1146278.s004
DOI:
10.3389/fncel.2023.1146278.s005
DOI:
10.3389/fncel.2023.1146278.s006
DOI:
10.3389/fncel.2023.1146278.s007
DOI:
10.3389/fncel.2023.1146278.s008
DOI:
10.3389/fncel.2023.1146278.s009
DOI:
10.3389/fncel.2023.1146278.s010
Language:
Unknown
Publisher:
Frontiers Media SA
Publication Date:
2023
detail.hit.zdb_id:
2452963-1
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