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  • 1
    In: Frontiers in Psychiatry, Frontiers Media SA, Vol. 13 ( 2022-10-6)
    Abstract: Lack of motivation is widely acknowledged as a significant factor in treatment discontinuity and poor treatment outcomes in eating disorders. Treatment adherence is lower in internet-based treatment. The current study aimed to assess the relationship between treatment motivation and treatment outcomes in an internet-based therapist-guided intervention for Binge Eating Disorder (BED). Method Adults ( N = 153) with mild to moderate symptoms of BED participated in a 10-session internet-based treatment program. Baseline and between-session scores of “Readiness to change” and “Belief in change” were used to predict treatment completion and eating disorder symptom reduction (EDE-Q Global, BED-Q, and weekly number of binge eating episodes) at post-treatment. Results Baseline treatment motivation could not predict treatment completion or symptom reduction. Early measures of treatment motivation (regression slope from sessions 1–5) significantly predicted both treatment completion and post-treatment symptom reduction. “Belief in change” was the strongest predictor for completing treatment (OR = 2.18, 95%-CI: 1.06, 4.46) and reducing symptoms (EDE-Q Global: B = −0.53, p = 0.001; number of weekly binge eating episodes: B = 0.81, p & lt; 0.01). Discussion The results indicated that patients entering online treatment for BED feel highly motivated. However, baseline treatment motivation could not significantly predict treatment completion, which contradicts previous research. The significant predictive ability of early measures of treatment motivation supports the clinical relevance of monitoring the development of early changes to tailor and optimize individual patient care. Further research is needed to examine treatment motivation in regard to internet-based treatment for BED with more validated measures.
    Type of Medium: Online Resource
    ISSN: 1664-0640
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2022
    detail.hit.zdb_id: 2564218-2
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  • 2
    In: Frontiers in Psychiatry, Frontiers Media SA, Vol. 13 ( 2022-11-4)
    Abstract: Online treatment for binge eating disorder (BED) is an easily available option for treatment compared to most standard treatment procedures. However, little is known about how motivation types characterize this population and how these impact treatment adherence and effect in an online setting. Therefore, we aimed to investigate a sample of written motivation statements from BED patients, to learn more about how treatment and online treatment in particular, presents in this population. Methods Using self-determination theory in a mixed methods context, we investigated which types of motivation were prevalent in our sample, how this was connected with patient sentiment, and how these constructs influence treatment and adherence. Results Contrary to what most current literature suggests, we found that in our sample ( n = 148), motivation type was not connected with treatment outcome. We did find a strong association between sentiment scores and motivation types, indicating the model is apt at detecting effects. We found that when comparing an adult and young adult population, they did not differ in motivation type and the treatment was equally effective in young adults and adults. In the sentiment scores there was a difference between sentiment score and adherence in the young adult group, as the more positive the young adults were, the less likely they were to complete the program. Discussion Because motivation type does not influence online treatment to the same degree as it would in face-to-face treatment it indicates that the typical barriers to treatment may be less crucial in an online setting. This should be considered during intake; as less motivated patients may be able to adhere better to online treatment, because the latter imposes fewer barriers of the kind that only strong motivation can overcome. The fact that motivation type and sentiment score of the written texts are strongly associated, indicate a potential for automated models to detect motivation based on sentiment.
    Type of Medium: Online Resource
    ISSN: 1664-0640
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2022
    detail.hit.zdb_id: 2564218-2
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  • 3
    Online Resource
    Online Resource
    Frontiers Media SA ; 2024
    In:  Frontiers in Virtual Reality Vol. 5 ( 2024-6-13)
    In: Frontiers in Virtual Reality, Frontiers Media SA, Vol. 5 ( 2024-6-13)
    Abstract: A large proportion of individuals with anxiety-related disorders refrain from seeking treatment. This may be because traditional exposure treatments induce anxiety. However, advances in exposure using virtual reality technology may encourage more individuals to seek treatment. Furthermore, using biomarkers with VR-based exposure may enable clinicians to assess anxiety levels objectively and collect data in a naturalistic setting. Methods: Here, we conduct a systematic review of the literature on the use of biomarkers in VR-based exposure treatment for anxiety. Twenty-seven studies were included, with a total of 1046 participants. Results We found that heart rate was the only biomarker that tentatively could identify changes within (75% of instances) and between sessions (60% of instances). The levels of synchrony between the findings for overall biomarkers and the results from questionnaires showed inconclusive results. Regarding the levels of synchrony between the findings for particular biomarkers and the results from questionnaires, only skin conductance level was highly synchronous for differences between groups (87% of instances). Conclusion Based on the present review, biomarkers cannot yet be used reliably to distinguish differences in self-reported symptoms of anxiety in VR-based exposure treatments.
    Type of Medium: Online Resource
    ISSN: 2673-4192
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2024
    detail.hit.zdb_id: 3017831-9
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  • 4
    In: Frontiers in Cardiovascular Medicine, Frontiers Media SA, Vol. 9 ( 2023-1-6)
    Abstract: Pulmonary arterial hypertension (PAH) is a disease characterized by elevated pulmonary vascular resistance and pulmonary artery pressure. Mortality remains high in severe cases despite significant advances in management and pharmacotherapy. Since currently approved PAH therapies are unable to significantly reverse pathological vessel remodeling, novel disease-modifying, targeted therapeutics are needed. Pathogenetically, PAH is characterized by vessel wall cell dysfunction with consecutive remodeling of the pulmonary vasculature and the right heart. Transcription factors (TFs) regulate the process of transcribing DNA into RNA and, in the pulmonary circulation, control the response of pulmonary vascular cells to macro- and microenvironmental stimuli. Often, TFs form complex protein interaction networks with other TFs or co-factors to allow for fine-tuning of gene expression. Therefore, identification of the underlying molecular mechanisms of TF (dys-)function is essential to develop tailored modulation strategies in PAH. This current review provides a compendium-style overview of TFs and TF complexes associated with PAH pathogenesis and highlights their potential as targets for vasculoregenerative or reverse remodeling therapies.
    Type of Medium: Online Resource
    ISSN: 2297-055X
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2023
    detail.hit.zdb_id: 2781496-8
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