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  • Frontiers Media SA  (23)
  • 1
    Online Resource
    Online Resource
    Wearable Electrocardiogram Quality Assessment Using Wavelet Scattering and LSTM
    Frontiers Media SA ; 2022
    In:  Frontiers in Physiology Vol. 13 ( 2022-6-30)
    Details
    In: Frontiers in Physiology, Frontiers Media SA, Vol. 13 ( 2022-6-30)
    Abstract: As the fast development of wearable devices and Internet of things technologies, real-time monitoring of ECG signals is quite critical for cardiovascular diseases. However, dynamic ECG signals recorded in free-living conditions suffered from extremely serious noise pollution. Presently, most algorithms for ECG signal evaluation were designed to divide signals into acceptable and unacceptable. Such classifications were not enough for real-time cardiovascular disease monitoring. In the study, a wearable ECG quality database with 50,085 recordings was built, including A/B/C (or high quality/medium quality/low quality) three quality grades (A: high quality signals can be used for CVD detection; B: slight contaminated signals can be used for heart rate extracting; C: heavily polluted signals need to be abandoned). A new SQA classification method based on a three-layer wavelet scattering network and transfer learning LSTM was proposed in this study, which can extract more systematic and comprehensive characteristics by analyzing the signals thoroughly and deeply. Experimental results ( mACC = 98.56%, mF 1 = 98.55%, Se A = 97.90%, Se B = 98.16%, Se C = 99.60%, + P A = 98.52%, + P B = 97.60%, + P C = 99.54%, F 1A = 98.20%, F 1B = 97.90%, F 1C = 99.60%) and real data validations proved that this proposed method showed the high accuracy, robustness, and computationally efficiency. It has the ability to evaluate the long-term dynamic ECG signal quality. It is advantageous to promoting cardiovascular disease monitoring by removing contaminating signals and selecting high-quality signal segments for further analysis.
    Type of Medium: Online Resource
    ISSN: 1664-042X
    URL: Article
    DOI: 10.3389/fphys.2022.905447
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2022
    detail.hit.zdb_id: 2564217-0
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  • 2
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    Video2.MP4
    Frontiers Media SA ; 2022
    In:  Frontiers in Physiology Vol. 13 ( 2022-11-9)
    Details
    In: Frontiers in Physiology, Frontiers Media SA, Vol. 13 ( 2022-11-9)
    Abstract: Aims: This study investigated the feasibility and accuracy of real-time three-dimensional (3D) echocardiographic transilluminated imaging (TrueVue Glass) in left atrial appendage (LAA) anatomical morphology and artificial intelligence (AI)-assisted 3D automated LAA measurement (3D Auto LAA) software in the preoperative evaluation of LAA occlusion (LAAO) in patients with atrial fibrillation (AF). Method and results: Thirty-seven patients with AF were selected. Two-dimensional (2D) and real-time 3D transesophageal echocardiography (RT3D-TEE) were performed preoperatively, using conventional 3D, the new 3D TrueVue Glass mode, and cardiac computed tomography angiography (CCTA) to assess and type the morphology of LAA. Physiological parameters were measured using traditional 2D and 3D manual (3D Manual LAA), 3D Auto LAA, and CCTA. TrueVue Glass for LAA outer contour display was compared with CCTA. Comparisons were based on correlation and consistency in measuring the maximum diameter (LZ max), minimum diameter (LZ min), area (LZ area), and circumference (LZ cir) of LAA landing zone (LZ). Times and variabilities were compared. The concordance rate for external shape of LAA was 97.14% between TrueVue Glass and CCTA. 3D Auto LAA and 3D Manual LAA have a stronger correlation and higher consistency in all parameters. 3D Auto LAA showed higher intra- and interobserver reproducibility and allowed quicker analysis ( p & lt; 0.05). LAAO was performed in 35 patients (94.59%), and none of which had serious adverse events. Conclusion: TrueVue Glass is the first non-invasive and radiation-free visualization of the overall external contour of LAA and its adjacent structures. 3D Auto LAA simplifies the measurement, making the preoperative assessment more efficient and convenient while ensuring the accuracy and reproducibility. A combination of the two is feasible for accurate and rapid assessment of LAA anatomy and physiology in AF patients and has practical application in LAAO.
    Type of Medium: Online Resource
    ISSN: 1664-042X
    URL: Article
    URL: Article
    URL: Article
    DOI: 10.3389/fphys.2022.1043551
    DOI: 10.3389/fphys.2022.1043551.s001
    DOI: 10.3389/fphys.2022.1043551.s002
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2022
    detail.hit.zdb_id: 2564217-0
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  • 3
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    Video3.MP4
    Frontiers Media SA ; 2022
    In:  Frontiers in Physiology Vol. 13 ( 2022-9-6)
    Details
    In: Frontiers in Physiology, Frontiers Media SA, Vol. 13 ( 2022-9-6)
    Abstract: Aims: This study explored the advantages and limitations of novel series of three-dimensional (3D) echocardiographic techniques and summarized their application methods for congenital heart diseases (CHDs). Method and result: Two-dimensional (2D), traditional 3D echocardiography, and TrueVue plus light and/or Glass novel 3D technologies were performed on 62 patients with CHD, and a clinical survey was designed to judge whether the novel 3D images were more helpful for understanding the cardiac condition and guide treatment than traditional 3D images. TrueVue increased the visual resolution and simulated the true texture of cardiac tissue, significantly improving the display ability of abnormal anatomical structures in CHDs. TrueVue Glass displayed the blood channel and the internal structure of cardiac cavity more intuitively, indicating a new observation aspect not shown by conventional echocardiography. The clinical survey results showed that the new 3D imaging methods effectively increased the diagnostic confidence of echocardiographers, enabled surgeons to better understand the details of lesions, promoted efficient communication, and improved the confidence of both doctors and patients in treatment. Conclusion: The combined application of TrueVue, TrueVue Light, and TrueVue Glass more closely simulated real anatomical features, showed more comprehensive and subtle blood flow in the lumen, not only increased the visual effect but also provided more useful diagnostic information, improved the accuracy of evaluation and treatment of CHD when compared to traditional imaging techniques, indicating that this combined application has significant clinical value.
    Type of Medium: Online Resource
    ISSN: 1664-042X
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    DOI: 10.3389/fphys.2022.1000007
    DOI: 10.3389/fphys.2022.1000007.s001
    DOI: 10.3389/fphys.2022.1000007.s002
    DOI: 10.3389/fphys.2022.1000007.s003
    DOI: 10.3389/fphys.2022.1000007.s004
    DOI: 10.3389/fphys.2022.1000007.s005
    DOI: 10.3389/fphys.2022.1000007.s006
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2022
    detail.hit.zdb_id: 2564217-0
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  • 4
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    The relationship between social creativity and aggressive behavior among Chinese junior high school students: The moderating role of hostile attribution bias
    Frontiers Media SA ; 2022
    In:  Frontiers in Psychology Vol. 13 ( 2022-11-24)
    Details
    In: Frontiers in Psychology, Frontiers Media SA, Vol. 13 ( 2022-11-24)
    Abstract: Recently, research has begun to pay attention to the dark side of creativity. This research attempted to explore the association between social creativity and aggressive behavior as well as the moderating role of hostile attribution bias. Data were obtained from 496 junior high school students in two cities in China using a convenience sampling technique. The results showed that different aspects of social creativity were different related to aggressive behavior. Specifically, appropriateness was negatively, and harmfulness was positively related to aggressive behavior; However, the relation between originality and aggressive behavior was not significant. In addition, hostile attribution bias moderated the relationships between appropriateness/harmfulness and aggressive behavior. Specifically, the negative relation between appropriateness and aggressive behavior as well as the positive relation between harmfulness and aggressive behavior became non-significant when hostile attribution bias was low. Implications of this study are also discussed.
    Type of Medium: Online Resource
    ISSN: 1664-1078
    URL: Article
    DOI: 10.3389/fpsyg.2022.953361
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2022
    detail.hit.zdb_id: 2563826-9
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  • 5
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    Data_Sheet_1.docx
    Frontiers Media SA ; 2023
    In:  Frontiers in Psychiatry Vol. 14 ( 2023-3-23)
    Details
    In: Frontiers in Psychiatry, Frontiers Media SA, Vol. 14 ( 2023-3-23)
    Abstract: Burnout and depression have overlapping symptoms, but the extent of overlap remains unclear, and the complex relationship between burnout and depression in pharmacists is rarely explored. Methods We investigated burnout and depression in 1,322 frontline pharmacists, and explored the complex relationship between burnout and depression in those pharmacists using network analysis. Results Network analysis showed that there were 5 communities. A partial overlap was found between burnout and depressive symptoms in pharmacists. The nodes MBI-6 (I have become more callous toward work since I took this job), D18 (My life is meaningless), and D10 (I get tired for no reason) had the highest expected influence value. D1 (I feel down-hearted and blue) and D14 (I have no hope for the future) were bridge symptoms connected with emotional exhaustion and reduced professional efficacy, respectively. Conclusion A partial overlap exists between burnout and depressive symptoms in pharmacists, mainly in the connection between the emotional exhaustion and reduced professional efficacy and the depressive symptoms. Potential core targets identified in this study may inform future prevention and intervention.
    Type of Medium: Online Resource
    ISSN: 1664-0640
    URL: Article
    URL: Article
    DOI: 10.3389/fpsyt.2023.1145606
    DOI: 10.3389/fpsyt.2023.1145606.s001
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2023
    detail.hit.zdb_id: 2564218-2
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  • 6
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    Cardiorespiratory Fitness, Age, and Multiple Aspects of Executive Function Among Preadolescent Children
    Frontiers Media SA ; 2020
    In:  Frontiers in Psychology Vol. 11 ( 2020-6-10)
    Details
    In: Frontiers in Psychology, Frontiers Media SA, Vol. 11 ( 2020-6-10)
    Type of Medium: Online Resource
    ISSN: 1664-1078
    URL: Article
    DOI: 10.3389/fpsyg.2020.01198
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2020
    detail.hit.zdb_id: 2563826-9
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  • 7
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    Table_1.xlsx
    Frontiers Media SA ; 2021
    In:  Frontiers in Oncology Vol. 11 ( 2021-9-27)
    Details
    In: Frontiers in Oncology, Frontiers Media SA, Vol. 11 ( 2021-9-27)
    Abstract: The extracellular matrix (ECM) plays a central role in the formation of the tumor microenvironment. The deposition of the ECM is associated with poor prognosis in a variety of tumors. Aberrant ECM deposition could undermine the effect of chemotherapy and immunotherapy. However, there is no systematic analysis on the relationship between the ECM and prognosis or chemotherapy effect. In the present study, we applied the gene set variation analysis (GSVA) algorithm to score 2199 canonical pathways in 2125 cases of probe or sequencing data and identified the core matrisome as the driving factor in gastric cancer progression. We classified gastric cancer samples into three clusters according to the composition of the ECM and evaluated clinical and multi-omics characterization of ECM phenotypes. The ECM score was evaluated by GSVA score of core matrisome and a higher ECM score predicted poor prognosis of gastric cancer [Hazard Ratio (HR), 2.084; p-value & lt; 2 × 10 −16 ]. In The Cancer Genome Atlas (TCGA) cohort and KUGH, YUSH, and KUCM cohorts, we verified that patients with a low ECM score could benefit from chemotherapy. By contrast, patients with a high ECM score did not achieve satisfactory response from chemotherapy. Determining the characteristics of the ECM microenvironment might help to predict the prognosis and chemotherapy response of patients with gastric cancer, and help to resolve the enigma of chemoresistance acquisition, as well as providing inspiration to develop combination therapy.
    Type of Medium: Online Resource
    ISSN: 2234-943X
    URL: Article
    URL: Article
    URL: Article
    DOI: 10.3389/fonc.2021.753330
    DOI: 10.3389/fonc.2021.753330.s001
    DOI: 10.3389/fonc.2021.753330.s002
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2021
    detail.hit.zdb_id: 2649216-7
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  • 8
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    Table_3.docx
    Frontiers Media SA ; 2022
    In:  Frontiers in Endocrinology Vol. 13 ( 2022-6-17)
    Details
    In: Frontiers in Endocrinology, Frontiers Media SA, Vol. 13 ( 2022-6-17)
    Abstract: Endoscopic bariatric and metabolic therapies (EBMTs) are emerging minimally invasive therapeutic options for obesity and its related complications, including non-alcoholic fatty liver disease (NAFLD). This study aimed to evaluate the effects of EBMTs on NALFD in patients with obesity. Methods Four databases were searched until Nov 2021. Randomized controlled trials (RCTs) and observational studies reporting liver-related outcomes following Food and Drug Administration (FDA)-approved and non-FDA-approved EBMTs were included. Liver parameters, metabolic parameters, and weight loss were evaluated. Risk of bias was assessed using the “risk of bias” tool in the Cochrane Collaboration for RCTs and the Methodological Index for Non-Randomized Studies criteria for observational studies. Results Thirty-three studies with 1710 individuals were included. Regarding the effects of EBMTs on liver fibrosis, a significant decline of NAFLD Fibrosis Score, but not transient elastography-detected liver stiffness or Fibrosis-4 Index, was observed. EBMTs significantly improved liver steatosis (control attenuation parameter and Hepatic Steatosis Index), NAFLD Activity Score, and Homeostasis Model Assessment of Insulin Resistance. EBMTs reduced serum levels of alanine transaminase, aspartate aminotransferase, and gamma-glutamyl transpeptidase considerably. Moreover, EBMTs had reducing effects on the serum levels of triglycerides and total cholesterol as well as body weight. Conclusions Our meta-analysis suggested that EBMTs could ameliorate NAFLD based on the evidence of improved liver steatosis, liver function, and insulin resistance. Large-scale, prospective, long-term studies are warranted to clarify the role of EBMTs in patients with different stages of NAFLD.
    Type of Medium: Online Resource
    ISSN: 1664-2392
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    DOI: 10.3389/fendo.2022.931519
    DOI: 10.3389/fendo.2022.931519.s001
    DOI: 10.3389/fendo.2022.931519.s002
    DOI: 10.3389/fendo.2022.931519.s003
    DOI: 10.3389/fendo.2022.931519.s004
    DOI: 10.3389/fendo.2022.931519.s005
    DOI: 10.3389/fendo.2022.931519.s006
    DOI: 10.3389/fendo.2022.931519.s007
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2022
    detail.hit.zdb_id: 2592084-4
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  • 9
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    A Novel Cold-Adaptive Endo-1,4-β-Glucanase From Burkholderia pyrrocinia JK-SH007: Gene Expression and Characterization of the Enzyme and Mode of Action
    Frontiers Media SA ; 2020
    In:  Frontiers in Microbiology Vol. 10 ( 2020-1-22)
    Details
    In: Frontiers in Microbiology, Frontiers Media SA, Vol. 10 ( 2020-1-22)
    Type of Medium: Online Resource
    ISSN: 1664-302X
    URL: Article
    DOI: 10.3389/fmicb.2019.03137
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2020
    detail.hit.zdb_id: 2587354-4
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  • 10
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    Image5.TIF
    Frontiers Media SA ; 2022
    In:  Frontiers in Genetics Vol. 13 ( 2022-6-8)
    Details
    In: Frontiers in Genetics, Frontiers Media SA, Vol. 13 ( 2022-6-8)
    Abstract: Gastric cancer (GC) is a highly fatal and common malignancy of the digestive system. Recent therapeutic advancements have significantly improved the clinical outcomes in GC, but due to the unavailability of suitable molecular targets, a large number of patients do not respond to the immune checkpoint inhibitors (ICI) therapy. To identify and validate potential therapeutic and prognostic targets of gastric cancer, we used the “inferCNV” R package for analyzing single-cell sequencing data (GSE112302) of GC and normal epithelial cells. First, by using LASSO, we screened genes that were highly correlated with copy number variations (CNVs). Therefrom, five gene signature ( CPVL , DDC , GRTP1 , ONECUT2 , and PRSS21 ) was selected by cross-validating the prognosis and risk management with the GC RNA-seq data obtained from GEO and TCGA. Moreover, the correlation analyses between CNVs of these genes and immune cell infiltration in gastric cancer identified CPVL as a potential prognostic marker. Finally, CPVL showed high expression in gastric cancer samples and cell lines, then siRNA-mediated silencing of CPVL expression in gastric cancer cells showed significant proliferation arrest in MGC803 cells. Here, we conclude that CNVs are key regulators of the immune cells infiltration in gastric TME as well as cancer development, and CPVL could potentially be used as a prognostic and therapeutic marker in gastric cancer.
    Type of Medium: Online Resource
    ISSN: 1664-8021
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    DOI: 10.3389/fgene.2022.869967
    DOI: 10.3389/fgene.2022.869967.s001
    DOI: 10.3389/fgene.2022.869967.s002
    DOI: 10.3389/fgene.2022.869967.s003
    DOI: 10.3389/fgene.2022.869967.s004
    DOI: 10.3389/fgene.2022.869967.s005
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2022
    detail.hit.zdb_id: 2606823-0
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