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  • 1
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    Image_4.JPEG
    Frontiers Media SA ; 2021
    In:  Frontiers in Neuroscience Vol. 15 ( 2021-2-18)
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    In: Frontiers in Neuroscience, Frontiers Media SA, Vol. 15 ( 2021-2-18)
    Abstract: Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by impairment in communication and social interaction, repetitive or stereotypical behaviors, altered sensory perception, and sleep disorders. In general, the causes of ASD remain unknown, but in Phelan–McDermid syndrome, it is known that the disorder is related to the haploinsufficiency of the Shank3 gene. We used an autism model with compromised glutamatergic signaling, the Shank3 +/– mouse, to study the circadian rhythm architecture of locomotion behavior and its entrainment to light. We also analyzed the synapse between the retinohypothalamic tract (RHT) and the suprachiasmatic nucleus (SCN), employing tract tracing and immunohistochemical techniques. We found that Shank3 +/– mice were not impaired in the SCN circadian clock, as indicated by a lack of differences between groups in the circadian architecture in entrained animals to either long or short photoperiods. Circadian rhythm periodicity (tau) was unaltered between genotypes in constant darkness (DD, dim red light). Similar results were obtained in the re-entrainment to shifts in the light–dark cycle and in the entrainment to a skeleton photoperiod from DD. However, Shank3 +/– mice showed larger phase responses to light pulses, both delays and advances, and rhythm disorganization induced by constant bright light. Immunohistochemical analyses indicated no differences in the RHT projection to the SCN or the number of SCN neurons expressing the N -methyl- D -aspartate (NMDA) receptor subunit NR2A, whereas the Shank3 +/– animals showed decreased c-Fos induction by brief light pulses at CT14, but increased number of vasoactive intestinal polypeptide (VIP)-positive neurons. These results indicate alterations in light sensitivity in Shank3 +/– mice. Further studies are necessary to understand the mechanisms involved in such increased light sensitivity, probably involving VIP neurons.
    Type of Medium: Online Resource
    ISSN: 1662-453X
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    DOI: 10.3389/fnins.2021.604165
    DOI: 10.3389/fnins.2021.604165.s001
    DOI: 10.3389/fnins.2021.604165.s002
    DOI: 10.3389/fnins.2021.604165.s003
    DOI: 10.3389/fnins.2021.604165.s004
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2021
    detail.hit.zdb_id: 2411902-7
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  • 2
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    DataSheet_1.docx
    Frontiers Media SA ; 2021
    In:  Frontiers in Oncology Vol. 11 ( 2021-11-5)
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    In: Frontiers in Oncology, Frontiers Media SA, Vol. 11 ( 2021-11-5)
    Abstract: Acute lymphoblastic leukemia (ALL) is characterized by an abnormal proliferation of immature lymphocytes, in whose development involves both environmental and genetic factors. It is well known that single nucleotide polymorphisms (SNPs) in coding and noncoding genes contribute to the susceptibility to ALL. This study aims to determine whether SNPs in miR-146a , miR-196a-2 , miR-499a , and miR-612 genes are associated with the risk to ALL in pediatric Mexican population. Methods A multicenter case-control study was carried out including patients with de novo diagnosis of ALL and healthy subjects as control group. The DNA samples were obtained from saliva and peripheral blood, and the genotyping of rs2910164, rs12803915, rs11614913, and rs3746444 was performed using the 5′exonuclease technique. Gene-gene interaction was evaluated by the multifactor dimensionality reduction (MDR) software. Results miR-499a rs3746444 showed significant differences among cases and controls. The rs3746444G allele was found as a risk factor to ALL (OR, 1.6 [95% CI, 1.05–2.5]; p = 0.028). The homozygous GG genotype of rs3746444 confers higher risk to ALL than the AA genotype (OR, 5.3 [95% CI, 1.23–23.4]; p = 0.01). Moreover, GG genotype highly increases the risk to ALL in male group (OR, 17.6 [95% CI, 1.04–298.9]; p = 0.00393). In addition, an association in a gender-dependent manner among SNPs located in miR-146a and miR-196a-2 genes and ALL susceptibility was found. Conclusion Our findings suggest that SNP located in miR-499a , miR-146a , and miR-196a-2 genes confer risk to ALL in Mexican children. Experimental analysis to decipher the role of these SNPs in human hematopoiesis could improve our understanding of the molecular mechanism underlying the development of ALL.
    Type of Medium: Online Resource
    ISSN: 2234-943X
    URL: Article
    URL: Article
    DOI: 10.3389/fonc.2021.762063
    DOI: 10.3389/fonc.2021.762063.s001
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2021
    detail.hit.zdb_id: 2649216-7
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  • 3
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    Table_1.docx
    Frontiers Media SA ; 2022
    In:  Frontiers in Endocrinology Vol. 13 ( 2022-8-24)
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    In: Frontiers in Endocrinology, Frontiers Media SA, Vol. 13 ( 2022-8-24)
    Abstract: Non-alcoholic fatty liver disease (NAFLD) is the most prevalent chronic liver disease in developed countries, with its incidence growing parallel to the epidemics of obesity and type 2 diabetes mellitus (T2DM). Sodium-glucose co-transporter-2 inhibitors (SGLT2i) are becoming a cornerstone in the management of cardiovascular health and some studies suggest the potential role in NAFLD. However, patients under treatment with SGLT2i are at risk of developing genitourinary fungal infections (GFIs). Moreover, both NAFLD and SGLT2i have a strong influence on the immune system, and therefore the risk of infections other than GFIs could be increased in NAFLD patients treated with SGLT2i. We aimed to examine the possible association of SGLT2i with infections and hepatic outcomes in NAFLD patients. Methods We conducted a case-control study including NAFLD patients with T2DM visited at the Liver Unit outpatient clinic from 2016 to 2021 with a minimum follow-up of 6 months by selecting 65 patients receiving SGLT2i and 130 matched patients with other types of antidiabetic treatment. Results During follow-up, GFIs were significantly higher in the SGLT2i group (15.4% vs. 3.8%; p=0.008), whereas there were no differences in the occurrence of overall infections (41.5% vs. 30%; p=0.1) nor in other types of specific infections. In the multivariable analysis, treatment with SGLT2i was not independently associated with higher odds of overall infection. On the other hand, SGLT2i patients showed a significantly lower incidence of hepatic events (1.5% vs. 10.7%; p=0.02). There were no significant different in all-cause mortality between cases and controls. Conclusions NAFLD patients with T2DM receiving SGLT2i more frequently presented GFIs, whereas the incidence of other types of infections was not found to be higher than in other patients with NAFLD and T2DM treated with other drugs. Moreover, SGLT2i-treated patients had a lower occurrence of hepatic events. Further studies are warranted to validate our data.
    Type of Medium: Online Resource
    ISSN: 1664-2392
    URL: Article
    URL: Article
    DOI: 10.3389/fendo.2022.945626
    DOI: 10.3389/fendo.2022.945626.s001
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2022
    detail.hit.zdb_id: 2592084-4
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  • 4
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    Table_1.XLS
    Frontiers Media SA ; 2021
    In:  Frontiers in Ecology and Evolution Vol. 9 ( 2021-3-17)
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    In: Frontiers in Ecology and Evolution, Frontiers Media SA, Vol. 9 ( 2021-3-17)
    Abstract: The Andes are a unique geological and biogeographic feature of South America. From the perspective of human geography, this mountain range provides ready access to highly diverse altitudinally arranged ecosystems. The combination of a geologically and ecologically diverse landscape provides an exceptional context to explore the potential of strontium isotopes to track the movements of people and the conveyance of material culture. Here we develop an isotopic landscape of bioavailable strontium (87Sr/86Sr) that is applied to reconstruct human paleogeography across time in the southern Andes of Argentina and Chile (31°–34°S). These results come from a macro-regional sampling of rodents ( N = 65) and plants ( N = 26) from modern and archeological contexts. This “Southern Andean Strontium Transect” extends over 350 km across the Andes, encompassing the main geological provinces between the Pacific coast (Chile) and the eastern lowlands (Argentina). We follow a recently developed approach to isoscape construction based on Random Forest regression and GIS analysis. Our results suggest that bioavailable strontium is tightly linked with bedrock geology and offers a highly resolved proxy to track human paleogeography involving the levels of territories or daily mobility and anomalous events that disrupt home ranges, such as migration. The southern Andes provide an ideal geological setting to develop this approach, since the geological variation in rock age and composition produces distinctive isotopic signatures for each main biogeographical region. Finally, we apply this framework to a set of results from human remains from the Uspallata Valley in Mendoza (Argentina), to assess the incidence of migration in the key period of the consolidation of agropastoral economies between AD 800 and 1400. The application of the isoscape to the values from human remains confirms the persistence of human groups with relatively restricted territories encompassing Uspallata and the adjacent Precordillera between AD 800 and 1500. We also identify a pulse of human migration between AD 1280 and 1420, shortly preceding the Inka conquest. Looking forward, we expect to converge with ongoing efforts in South America to build a continental research framework to track the movement of people, animals, and artifacts across space and time.
    Type of Medium: Online Resource
    ISSN: 2296-701X
    URL: Article
    URL: Article
    URL: Article
    DOI: 10.3389/fevo.2021.584325
    DOI: 10.3389/fevo.2021.584325.s001
    DOI: 10.3389/fevo.2021.584325.s002
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2021
    detail.hit.zdb_id: 2745634-1
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