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  • 1
    Online Resource
    Online Resource
    Video_2.mp4
    Frontiers Media SA ; 2022
    In:  Frontiers in Marine Science Vol. 9 ( 2022-5-10)
    Details
    In: Frontiers in Marine Science, Frontiers Media SA, Vol. 9 ( 2022-5-10)
    Abstract: Anthropogenic greenhouse gas emissions are triggering changes in global climate and warming the ocean. This will affect many marine organisms, particularly those with high site fidelity and habitat temperature preferences, such as humpback whales on their breeding grounds. To study the impacts of a warming ocean on marine organisms, large-scale projections of climatic variables are crucial. Global models are of 0.25 - 1° (~25-100 km) resolution, and not ideal to predict localized changes. Here, we provide 0.05° resolution (~5 km) sea surface temperature (SST) projections, statistically downscaled using the delta method. We illustrate the shifting isotherms of the critical 21 and 28°C boundaries, which border the climatic envelope that humpback whales prefer for their breeding grounds, over the course of the 21st century on a decadal temporal resolution. Results show by the end of the 21st century, 35% of humpback whale breeding areas will experience SSTs above or within 1°C of current thresholds if present-day social, economic, and technological trends continue (‘middle of the road’ CMIP6 greenhouse gas trajectory SSP2-RCP4.5). This number rises to 67% under the scenario describing rapid economic growth in carbon-intensive industries (‘fossil-fueled development’ CMIP6 greenhouse gas trajectory SSP5-RCP8.5). These projections highlight the importance of reducing global greenhouse gas emissions and minimizing further SST increases to preserve ecological integrity of humpback whale breeding areas. In this context, our results emphasize the need to focus on protection of critical ocean habitat and to provide high-resolution climate data for this purpose.
    Type of Medium: Online Resource
    ISSN: 2296-7745
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    DOI: 10.3389/fmars.2022.837772
    DOI: 10.3389/fmars.2022.837772.s001
    DOI: 10.3389/fmars.2022.837772.s002
    DOI: 10.3389/fmars.2022.837772.s003
    DOI: 10.3389/fmars.2022.837772.s004
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2022
    detail.hit.zdb_id: 2757748-X
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  • 2
    Online Resource
    Online Resource
    COVID-19 stressors for Hispanic/Latino patients living with type 2 diabetes: a qualitative study
    Frontiers Media SA ; 2023
    In:  Frontiers in Clinical Diabetes and Healthcare Vol. 4 ( 2023-4-28)
    Details
    In: Frontiers in Clinical Diabetes and Healthcare, Frontiers Media SA, Vol. 4 ( 2023-4-28)
    Abstract: During the early stages of the COVID-19 pandemic, nationwide lockdowns caused disruption in the diets, physical activities, and lifestyles of patients with type 2 diabetes. Previous reports on the possible association between race/ethnicity, COVID-19, and mortality have shown that Hispanic/Latino patients with type 2 diabetes who are socioeconomically disadvantaged are disproportionately affected by this novel virus. The aim of this study was to explore stressors associated with changes in diabetes self-management behaviors. Our goal was to highlight the health disparities in these vulnerable racial/ethnic minority communities and underscore the need for effective interventions. Methods and participants Participants were enrolled in part of a larger randomized controlled trial to compare diabetes telehealth management (DTM) with comprehensive outpatient management (COM) in terms of critical patient-centered outcomes among Hispanic/Latino patients with type 2 diabetes. We conducted a thematic analysis using patient notes collected from two research nurses between March 2020 and March 2021. Two authors read through the transcripts independently to identify overarching themes. Once the themes had been identified, both authors convened to compare themes and ensure that similar themes were identified within the transcripts. Any discrepancies were discussed by the larger study team until a consensus was reached. Results Six themes emerged, each of which can be categorized as either a source or an outcome of stress. Sources of stress associated with the COVID-19 pandemic were (1) fear of contracting COVID-19, (2) disruptions from lockdowns, and (3) financial stressors (e.g., loss of income). Outcomes of COVID-19 stressors were (1) reduced diabetes management (e.g., reduced diabetes monitoring and physical activity), (2) suboptimal mental health outcomes (e.g., anxiety and depression), and (3) outcomes of financial stressors. Conclusion The findings indicated that underserved Hispanic/Latino patients with type 2 diabetes encountered a number of stressors that led to the deterioration of diabetes self-management behaviors during the pandemic.
    Type of Medium: Online Resource
    ISSN: 2673-6616
    URL: Article
    DOI: 10.3389/fcdhc.2023.1070547
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2023
    detail.hit.zdb_id: 3101070-2
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  • 3
    Online Resource
    Online Resource
    Plasmacytoid Dendritic Cells as Cell-Based Therapeutics: A Novel Immunotherapy to Treat Human Immunodeficiency Virus Infection?
    Frontiers Media SA ; 2020
    In:  Frontiers in Cellular and Infection Microbiology Vol. 10 ( 2020-5-26)
    Details
    In: Frontiers in Cellular and Infection Microbiology, Frontiers Media SA, Vol. 10 ( 2020-5-26)
    Type of Medium: Online Resource
    ISSN: 2235-2988
    URL: Article
    DOI: 10.3389/fcimb.2020.00249
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2020
    detail.hit.zdb_id: 2619676-1
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  • 4
    Online Resource
    Online Resource
    Presentation_1.PPTX
    Frontiers Media SA ; 2021
    In:  Frontiers in Microbiology Vol. 12 ( 2021-11-26)
    Details
    In: Frontiers in Microbiology, Frontiers Media SA, Vol. 12 ( 2021-11-26)
    Abstract: The chemokine receptor CCR5 is expressed on multiple cell types, including macrophages, dendritic cells, and T cells, and is the major co-receptor used during HIV transmission. Using a standard αCD3/CD28 in vitro stimulation protocol to render CD4+ T cells from PBMCs permissive to HIV infection, we discovered that the percentage of CCR5 + T cells was significantly elevated in CD4+ T cells when stimulated in the presence of peripheral blood mononuclear cells (PBMCs) as compared to when stimulated as purified CD4+ T cells. This indicated that environmental factors unique to the T-PBMCs condition affect surface expression of CCR5 on CD4+ T cells. Conditioned media from αCD3/CD28-stimulated PBMCs induced CCR5 expression in cultures of unstimulated cells. Cytokine profile analysis of these media suggests IL-12 as an inducer of CCR5 expression. Mass cytometric analysis showed that stimulated T-PBMCs exhibited a uniquely activated phenotype compared to T-Pure. In line with increased CCR5 expression and activation status in stimulated T-PBMCs, CD4+ T cells from these cultures were more susceptible to infection by CCR5-tropic HIV-1 as compared with T-Pure cells. These results suggest that in order to increase ex vivo infection rates of blood-derived CD4+ T cells, standard stimulation protocols used in HIV infection studies should implement T-PBMCs or purified CD4+ T cells should be supplemented with IL-12.
    Type of Medium: Online Resource
    ISSN: 1664-302X
    URL: Article
    URL: Article
    DOI: 10.3389/fmicb.2021.763030
    DOI: 10.3389/fmicb.2021.763030.s001
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2021
    detail.hit.zdb_id: 2587354-4
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