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  • Frontiers Media SA  (7)
  • 1
    Online Resource
    Online Resource
    Image_2.TIF
    Frontiers Media SA ; 2018
    In:  Frontiers in Microbiology Vol. 9 ( 2018-5-29)
    Details
    In: Frontiers in Microbiology, Frontiers Media SA, Vol. 9 ( 2018-5-29)
    Type of Medium: Online Resource
    ISSN: 1664-302X
    URL: Article
    URL: Article
    URL: Article
    DOI: 10.3389/fmicb.2018.01056
    DOI: 10.3389/fmicb.2018.01056.s001
    DOI: 10.3389/fmicb.2018.01056.s002
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2018
    detail.hit.zdb_id: 2587354-4
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  • 2
    Online Resource
    Online Resource
    Table_7.xlsx
    Frontiers Media SA ; 2023
    In:  Frontiers in Cellular and Infection Microbiology Vol. 13 ( 2023-5-12)
    Details
    In: Frontiers in Cellular and Infection Microbiology, Frontiers Media SA, Vol. 13 ( 2023-5-12)
    Abstract: To identify differences between the composition, abundance, and biological function of the intestinal microbiome of patients with and without lymph-vascular invasion (LVI) colorectal cancer (CRC) and to construct predictive labels to support accurate assessment of LVI in CRC. Method 134 CRC patients were included, which were divided into two groups according to the presence or absence of LVI, and their intestinal microbiomes were sequenced by 16SrRNA and analyzed for differences. The transcriptome sequencing data of 9 CRC patients were transformed into immune cells abundance matrix by CIBERSORT algorithm, and the correlation among LVI-associated differential intestinal microbiomes, immune cells, immune-related genes and LVI-associated differential GO items and KEGG pathways were analyzed. A random forest (RF) and eXtreme Gradient Boosting (XGB) model were constructed to predict the LVI of CRC patients based on the differential microbiome. Result There was no significant difference in α-diversity and β-diversity of intestinal microbiome between CRC patients with and without LVI (P & gt; 0.05). Linear discriminant analysis Effect Size (LEfSe) analysis showed 34 intestinal microbiomes enriched in CRC patients of the LVI group and 5 intestinal microbiomes were significantly enriched in CRC patients of the non-lymph-vascular invasion (NLVI) group. The RF and XGB prediction models constructed with the top 15% of the LVI-associated differential intestinal microbiomes ranked by feature significance had good efficacy. Conclusions There are 39 intestinal flora with significantly different species abundance between the LVI and NLVI groups. g:Alistipes.s:Alistipes_indistinctus is closely associated with colorectal cancer vascular invasion. LVI-associated differential intestinal flora may be involved in regulating the infiltration of immune cells in CRC and influencing the expression of immune-related genes. LVI-associated differential intestinal flora may influence the process of vascular invasion in CRC through a number of potential biological functions. RF prediction models and XGB prediction models constructed based on microbial markers of gut flora can be used to predict CRC-LVI conditions.
    Type of Medium: Online Resource
    ISSN: 2235-2988
    URL: Article
    URL: Article
    URL: Article
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    URL: Article
    URL: Article
    URL: Article
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    URL: Article
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    URL: Article
    DOI: 10.3389/fcimb.2023.1098310
    DOI: 10.3389/fcimb.2023.1098310.s001
    DOI: 10.3389/fcimb.2023.1098310.s002
    DOI: 10.3389/fcimb.2023.1098310.s003
    DOI: 10.3389/fcimb.2023.1098310.s004
    DOI: 10.3389/fcimb.2023.1098310.s005
    DOI: 10.3389/fcimb.2023.1098310.s006
    DOI: 10.3389/fcimb.2023.1098310.s007
    DOI: 10.3389/fcimb.2023.1098310.s008
    DOI: 10.3389/fcimb.2023.1098310.s009
    DOI: 10.3389/fcimb.2023.1098310.s010
    DOI: 10.3389/fcimb.2023.1098310.s011
    DOI: 10.3389/fcimb.2023.1098310.s012
    DOI: 10.3389/fcimb.2023.1098310.s013
    DOI: 10.3389/fcimb.2023.1098310.s014
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2023
    detail.hit.zdb_id: 2619676-1
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  • 3
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    Corrigendum: Orf Virus 002 Protein Targets Ovine Protein S100A4 and Inhibits NF-κB Signaling
    Frontiers Media SA ; 2017
    In:  Frontiers in Microbiology Vol. 8 ( 2017-02-07)
    Details
    In: Frontiers in Microbiology, Frontiers Media SA, Vol. 8 ( 2017-02-07)
    Type of Medium: Online Resource
    ISSN: 1664-302X
    URL: Article
    DOI: 10.3389/fmicb.2017.00160
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2017
    detail.hit.zdb_id: 2587354-4
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  • 4
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    Focal Mechanism and Seismogenic Structure of the MS 5.1 Qingbaijiang Earthquake on February 3, 2020, Southwestern China
    Frontiers Media SA ; 2021
    In:  Frontiers in Earth Science Vol. 9 ( 2021-5-26)
    Details
    In: Frontiers in Earth Science, Frontiers Media SA, Vol. 9 ( 2021-5-26)
    Abstract: The 3 February 2020 M S 5.1 Qingbaijiang earthquake, southwestern China, is the closest recorded M S ≥ 5.0 event to downtown Chengdu City to date, with an epicentral distance of only 38 km. Here we analyze seismic data from the Sichuan and Chengdu regional seismic networks, and employ a multi-stage location method to relocate the earthquakes that have occurred along the central and northern segments of the Longquanshan fault zone since 2009, including the M S 5.1 Qingbaijiang earthquake sequence, to investigate the seismogenic structure of the region. The relocation results indicate that the seismicity along the central and northern segments of the Longquanshan fault zone has occurred mainly along the eastern branch since 2009, with the hypocentral distribution along a vertical cross-section illustrating a steep, NW-dipping parallel imbricate structure. The terminating depth of the eastern branch is about 12 km. The distribution of the M S 5.1 Qingbaijiang earthquake sequence is along the NE–SW-striking Longquanshan fault zone. The aftershock focal depths are in the 3–6 km range, with the mainshock located at 104.475°E, 30.73°N. Its initial rupture depth of 5.2 km indicates that the earthquake occurred above the shallow decollement layer of the upper crust in this region. The hypocentral distribution along the long axis of the aftershock area highlights that this earthquake sequence occurred along a fault dipping at 56° to the NW. Our surface projection of the inferred fault plane places it near the eastern branch of the Longquanshan fault zone. We infer the M S 5.1 mainshock to be a thrust faulting event based on the focal mechanism solution via the cut-and-paste waveform inversion method, with strike/dip/rake parameters of 22°/36°/91° and 200°/54°/89° obtained for nodal planes I and II, respectively. We identify that the seismogenic fault of the M S 5.1 Qingbaijiang earthquake lies along the eastern branch of the Longquanshan fault zone, and nodal plane II represents the coseismic rupture plane, based on a joint analysis of the event relocation results, mainshock focal mechanism, and regional geological information. Our study provides vital information for assessing the seismic hazard of the Longquanshan fault zone near Chengdu City.
    Type of Medium: Online Resource
    ISSN: 2296-6463
    URL: Article
    DOI: 10.3389/feart.2021.644142
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2021
    detail.hit.zdb_id: 2741235-0
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  • 5
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    Permian sedimentary evolution and hydrocarbon accumulation effects in the central-southern South Yellow Sea Basin
    Frontiers Media SA ; 2023
    In:  Frontiers in Earth Science Vol. 11 ( 2023-5-9)
    Details
    In: Frontiers in Earth Science, Frontiers Media SA, Vol. 11 ( 2023-5-9)
    Abstract: The South Yellow Sea Basin (SYSB) is an extension of the Lower Yangtze Block to the sea. The basin has undergone a complex tectonic-sedimentary evolution, and there has been no breakthrough in oil and gas exploration. Based on newly collected and processed well drilling data, cores, and seismic data of the central-southern SYSB and adjacent areas, the understudy area is set in the Lower Yangtze Region (LYR) to compare the overall sequence division and sedimentary facies. The Permian isochronous stratigraphic framework is methodically established in the central-southern SYSB, and the corresponding sedimentary facies and their distribution are examined in some detail. Finally, together with the previous investigations of tectonic evolution, the potential Permian oil-gas accumulation modes are proposed. The achieved results reveal that the second-order Permian sequence developed in the central-southern SYSB is consistent with the LYR. There exists a relatively complete second-order sequence I developed in the middle-bottom section and the transgressive systems tract of sequence II in the upper section. The Permian sedimentary system in the central-southern SYSB can be compared to the LYR and is generally distributed in a northeast direction. The transgressive systems tract of sequence I is broadly developed with the restricted platform and open platform as the dominant facies. The highstand systems tract of sequence I has been only developed in the northwest of the understudy area, with the shelf as the dominant facies. The transgressive systems tract of sequence II is mostly dominated by delta facies and swamp-lagoon facies with thick coal-measure layers, which provide a material basis for the formation of large-scale oil and gas fields. The thermal evolution of Permian source rocks was controlled by a combination of tectonic evolution and paleothermal gradient. Permian source rocks may have experienced secondary hydrocarbon generation in the western part of the southern Depression, whereas source rocks elsewhere experience only one hydrocarbon generation in the Early Triassic. The obtained results reveal that there are significant differences in the accumulation mode of different structural units.
    Type of Medium: Online Resource
    ISSN: 2296-6463
    URL: Article
    DOI: 10.3389/feart.2023.1176929
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2023
    detail.hit.zdb_id: 2741235-0
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  • 6
    Online Resource
    Online Resource
    Tectonic evolution and its control on oil–gas accumulation in southern East China Sea since the Jurassic
    Frontiers Media SA ; 2023
    In:  Frontiers in Earth Science Vol. 10 ( 2023-1-6)
    Details
    In: Frontiers in Earth Science, Frontiers Media SA, Vol. 10 ( 2023-1-6)
    Abstract: Based on the results from the previous research on Mesozoic igneous rocks, as well as tectonic environments in the northern South China Sea and southern East China Sea (NSCS-SECS), geophysical parameters, strata, and characteristics of seismic facies in NSCS-SECS were investigated. These findings were combined with results from the analysis of the balanced profile evolution to re-evaluate the tectonic evolution of SECS since the Jurassic. Furthermore, burial history and simulation of wells in the SECS were analyzed using well, seismic and source rock data. Furthermore, favorable models of oil–gas accumulation in the Lower–Middle Jurassic were proposed in combination with studies on elements and conditions of the petroleum system. The results demonstrated that the NSCS-SECS had consistent tectonic settings and comparable strata from the Jurassic to the Cretaceous time. There was a large unified basin in this period. The basin experienced two evolutionary stages, respectively, the fore-arc depression basin in the Early–Middle Jurassic (J 1-2 ) and the back-arc faulted basin in the Late Jurassic–Cretaceous (J 3 -K). There was considerable deposition of dark mudstones in the SECS during the Lower–Middle Jurassic. The Keelung Sag was the depositional center accumulating the thickest section of the Lower–Middle Jurassic source rocks which entered a high-maturity stage. Hence, it was the hydrocarbon generation center in the SECS. The process of generating hydrocarbons from Lower–Middle Jurassic source rocks was of high complexity from northwest to southeast. The Lower–Middle Jurassic source rock at the northwest edges of the basin experienced two hydrocarbon generation stages, while the Keelung Sag toward the southeast experienced three hydrocarbon generation stages. The models and types of oil–gas accumulation in various evolutionary phases were different due to the control by tectonic evolution. Oil and gas that were generated by Lower–Middle Jurassic source rocks in the Keelung Sag migrated and accumulated in the western high-tectonic units. Research findings provide insights into Mesozoic oil and gas exploration in the NSCS-SECS.
    Type of Medium: Online Resource
    ISSN: 2296-6463
    URL: Article
    DOI: 10.3389/feart.2022.1015832
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2023
    detail.hit.zdb_id: 2741235-0
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  • 7
    Online Resource
    Online Resource
    Orf Virus 002 Protein Targets Ovine Protein S100A4 and Inhibits NF-κB Signaling
    Frontiers Media SA ; 2016
    In:  Frontiers in Microbiology Vol. 7 ( 2016-09-13)
    Details
    In: Frontiers in Microbiology, Frontiers Media SA, Vol. 7 ( 2016-09-13)
    Type of Medium: Online Resource
    ISSN: 1664-302X
    URL: Article
    DOI: 10.3389/fmicb.2016.01389
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2016
    detail.hit.zdb_id: 2587354-4
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