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Small Posterior Cranial Fossa and Cerebellopontine Cistern Volumes Are Associated With Bilateral Trigeminal Neuralgia

Liu, Jiayu ; Liu, Ruen ; Liu, Bo ; [et al.]

Frontiers Media SA ; 2020

In: Frontiers in Neurology Vol. 11 ( 2020-10-15)

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In: Frontiers in Neurology, Frontiers Media SA, Vol. 11 ( 2020-10-15)

Type of Medium: Online Resource

ISSN: 1664-2295

URL: Article

DOI: 10.3389/fneur.2020.573239

Language: Unknown

Publisher: Frontiers Media SA

Publication Date: 2020

detail.hit.zdb_id: 2564214-5

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Table_1.DOC

Huang, Ma-Sha ; Liu, Jun-Yan ; Xia, Xiao-Bo ; [et al.]

Frontiers Media SA ; 2019

In: Frontiers in Oncology Vol. 9 ( 2019-6-12)

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In: Frontiers in Oncology, Frontiers Media SA, Vol. 9 ( 2019-6-12)

Type of Medium: Online Resource

ISSN: 2234-943X

URL: Article

DOI: 10.3389/fonc.2019.00508

DOI: 10.3389/fonc.2019.00508.s001

Language: Unknown

Publisher: Frontiers Media SA

Publication Date: 2019

detail.hit.zdb_id: 2649216-7

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Table_9.xlsx

Liu, Mingyang ; Sun, Cunxin ; Zheng, Xiaochuan ; [et al.]

Frontiers Media SA ; 2022

In: Frontiers in Immunology Vol. 13 ( 2022-5-31)

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In: Frontiers in Immunology, Frontiers Media SA, Vol. 13 ( 2022-5-31)

Abstract: Tea tree oil (TTO) is a pure natural plant essential oil. The studies evaluated the hepatopancreas lipid metabolism and antioxidant efficacy of Macrobrachium rosenbergii fed with 0 (CT group) and 100 mg/kg TTO (TT group) by label-free quantification proteomic analysis. Compared to the CT group, the TT group improved growth performance and increased the survival rate after stress. Dietary TTO also decreased hemolymph AST and ALT activities and decreased hepatopancreatic vacuolation. At the same time, hepatopancreas lipids droplets and hemolymph lipids (TG, TC, LDL-C) were decreased, and the peroxidation products content (MDA, LPO, 4-HNE) was also decreased. In addition, the levels of hepatopancreas antioxidant enzymes (T-AOC, CAT, and SOD) were increased in the TT group. With proteomic analysis, a total of 151 differentially expressed proteins (DEPs) (99 up-regulated and 52 down-regulated) were identified in the hepatopancreas. Kyoto Encyclopedia of Genes and Genomes (KEGG) and protein-protein interaction analysis showed that the 16 DEPs have interactions, which are mainly involved in the pathways related to lipid metabolism (fatty acid biosynthesis, fatty acid metabolism, glycerophospholipid metabolism) and redox reaction (cytochrome P450 enzyme systems). Furthermore, the mRNA expression of 15 proteins followed the proteomic analysis with qRT-PCR validation. Pearson correlation analysis showed that fatty acids and glycerophospholipid metabolism-related proteins were highly correlated to peroxide content, glycerophospholipid metabolism, and cytochrome P450 system-related proteins (CYP1A1, GSTT1, GPX4) were highly correlated to AST and ALT. Additionally, GPX4 is closely related to peroxide content and antioxidant enzyme activity. Our results revealed that TTO plays a protective role in the hepatopancreas targeting the critical enzymes and antioxidant reactions in lipid metabolism. Provides a new perspective to elucidate the action path of TTO in protecting invertebrate hepatopancreas, highlights the influence of lipid metabolism on hepatopancreas health and the interaction between lipid metabolism and antioxidant system in the regulation of TTO.

Type of Medium: Online Resource

ISSN: 1664-3224

URL: Article

DOI: 10.3389/fimmu.2022.906435

DOI: 10.3389/fimmu.2022.906435.s001

DOI: 10.3389/fimmu.2022.906435.s002

DOI: 10.3389/fimmu.2022.906435.s003

DOI: 10.3389/fimmu.2022.906435.s004

DOI: 10.3389/fimmu.2022.906435.s005

DOI: 10.3389/fimmu.2022.906435.s006

DOI: 10.3389/fimmu.2022.906435.s007

DOI: 10.3389/fimmu.2022.906435.s008

DOI: 10.3389/fimmu.2022.906435.s009

DOI: 10.3389/fimmu.2022.906435.s010

DOI: 10.3389/fimmu.2022.906435.s011

DOI: 10.3389/fimmu.2022.906435.s012

DOI: 10.3389/fimmu.2022.906435.s013

DOI: 10.3389/fimmu.2022.906435.s014

DOI: 10.3389/fimmu.2022.906435.s015

DOI: 10.3389/fimmu.2022.906435.s016

DOI: 10.3389/fimmu.2022.906435.s017

DOI: 10.3389/fimmu.2022.906435.s018

DOI: 10.3389/fimmu.2022.906435.s019

Language: Unknown

Publisher: Frontiers Media SA

Publication Date: 2022

detail.hit.zdb_id: 2606827-8

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miR-6869-5p Transported by Plasma Extracellular Vesicles Mediates Renal Tubule Injury and Renin-Angiotensin System Activation in Obesity

Liu, Huan-Huan ; Li, Xia-Qing ; Liu, Jin-Feng ; [et al.]

Frontiers Media SA ; 2021

In: Frontiers in Medicine Vol. 8 ( 2021-9-8)

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In: Frontiers in Medicine, Frontiers Media SA, Vol. 8 ( 2021-9-8)

Abstract: Obesity increases the risk of other diseases, including kidney disease. Local renal tubular renin-angiotensin system (RAS) activation may play a role in obesity-associated kidney disease. Extracellular vehicles (EVs) transmit necessary information in obesity and cause remote organ damage, but the mechanism is unclear. The aim of the study was to investigate whether the plasma EVs cargo miR-6869-5p causes RAS activation and renal tubular damage. We isolated plasma EVs from obese and lean subjects and analyzed differentially-expressed miRNAs using RNA-seq. Then, EVs were co-cultured with human proximal renal tubular epithelial cells (PTECs) in vitro . Immunohistochemical pathology was used to assess the degree of RAS activation and tubule injury in vivo . The tubule damage-associated protein and RAS activation components were detected by Western blot. Obesity led to renal tubule injury and RAS activation in humans and mice. Obese-EVs induce RAS activation and renal tubular injury in PTECs. Importantly, miR-6869-5p-treated PTECs caused RAS activation and renal tubular injury, similar to Obese-EVs. Inhibiting miR-6869-5p decreased RAS activation and renal tubular damage. Our findings indicate that plasma Obese-EVs induce renal tubule injury and RAS activation via miR-6869-5p transport. Thus, miR-6869-5p in plasma Obese-EVs could be a therapeutic target for local RAS activation in obesity-associated kidney disease.

Type of Medium: Online Resource

ISSN: 2296-858X

URL: Article

DOI: 10.3389/fmed.2021.725598

Language: Unknown

Publisher: Frontiers Media SA

Publication Date: 2021

detail.hit.zdb_id: 2775999-4

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Kirkpatrick-Baez mirrors commissioning for coherent scattering and imaging endstation at SXFEL

Tong, Yajun ; Fan, Jiadong ; Nie, Yonggan ; [et al.]

Frontiers Media SA ; 2022

In: Frontiers in Physics Vol. 10 ( 2022-8-30)

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In: Frontiers in Physics, Frontiers Media SA, Vol. 10 ( 2022-8-30)

Abstract: Shanghai Soft X-ray Free-Electron Laser (SXFEL) is the first X-ray free-electron laser facility in China. The initial commissioning of the beamline was carried out in May 2021. Herein, we present a status report and the first experimental results obtained during the early commissioning of Kirkpatrick-Baez (KB) mirrors for the Coherent Scattering and Imaging (CSI) endstation, including three types of diagnostics. A bright X-ray focal spot of less than 3 μm was achieved by using edge-scan and silicon ablation imprint measurements. In order to confirm the spot size, the attenuated beam and full beam are used respectively for the two measurement methods.

Type of Medium: Online Resource

ISSN: 2296-424X

URL: Article

DOI: 10.3389/fphy.2022.977957

Language: Unknown

Publisher: Frontiers Media SA

Publication Date: 2022

detail.hit.zdb_id: 2721033-9

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data_sheet_2.DOCX

Shen, Dongchao ; Hou, Bo ; Xu, Yinyan ; [et al.]

Frontiers Media SA ; 2018

In: Frontiers in Neurology Vol. 9 ( 2018-5-24)

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In: Frontiers in Neurology, Frontiers Media SA, Vol. 9 ( 2018-5-24)

Type of Medium: Online Resource

ISSN: 1664-2295

URL: Article

DOI: 10.3389/fneur.2018.00364

DOI: 10.3389/fneur.2018.00364.s001

DOI: 10.3389/fneur.2018.00364.s002

Language: Unknown

Publisher: Frontiers Media SA

Publication Date: 2018

detail.hit.zdb_id: 2564214-5

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Long-Term Effect of Early Post-operative Transcutaneous Electrical Stimulation on Voiding Function After Radical Hysterectomy: A Multicenter, Randomized, Controlled Trial

Li, Xiao-wei ; Gao, Lei ; Wang, Qing ; [et al.]

Frontiers Media SA ; 2021

In: Frontiers in Medicine Vol. 8 ( 2021-9-30)

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In: Frontiers in Medicine, Frontiers Media SA, Vol. 8 ( 2021-9-30)

Abstract: Introduction: Post-radical-hysterectomy (RH) patients suffer from a series of problems resulting from neurovascular injury, such as bladder dysfunction, which reduce their quality of life. We have designed this study to evaluate the efficacy of transcutaneous electrical stimulation (TENS) on patient rehabilitation after RH for early cervical cancer. Materials and methods: A total of 97 patients were enrolled in a randomized-controlled trial (from January 2015 to December 2019) involving 7 medical centers nationwide. Patients were assigned to either the intervention group ( n = 46), or the control group ( n = 51). TENS was given to patients in the intervention group from the 7 th day after surgery for a total of 14–21 days. The control group received no TENS. Primary outcomes were measured for residual urine volume and recovery of urination function. Secondary outcomes were measures for urodynamics (UDS), pelvic floor electromyography function examination (PFEmF), and quality of life (QoL). Results: Residual urine volume and improvement in the rate of urination were found to show no significant differences on the 14 th , 21 st , and 28 th days after surgery. The maximum flow rate (Qmax) in the intervention group was significantly higher than that in the control group on the 28 th day, but there were no significant differences in average flow rate, voiding time, time to Qmax, muscle fiber strength, muscle fiber fatigue, and the abnormal rate of A3 reflection on the 28 th day and the 3 rd mo., as well as in the QoL at 3 rd mo., 6 th mo., and 12 th mo. after surgery. Conclusion: Our study showed no sufficient evidence to prove that TENS under the trialed parameters could improve the subject's voiding function, PFEmF, and QOL after RH. This has provided valuable data for rehabilitation after RH. Clinical Trial Registration: www.ClinicalTrials.gov , identifier: NCT02492542.

Type of Medium: Online Resource

ISSN: 2296-858X

URL: Article

DOI: 10.3389/fmed.2021.677029

Language: Unknown

Publisher: Frontiers Media SA

Publication Date: 2021

detail.hit.zdb_id: 2775999-4

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A Pyridazinone Compound for Effectively Treating Non-alcoholic Steatohepatitis by Targeting THRβ

Cheng, Hao ; Wang, Xiao-Bo ; Zhi, Ying ; [et al.]

Frontiers Media SA ; 2022

In: Frontiers in Chemistry Vol. 10 ( 2022-5-10)

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In: Frontiers in Chemistry, Frontiers Media SA, Vol. 10 ( 2022-5-10)

Abstract: Developing effective therapies and medicines to conquer nonalcoholic steatohepatitis (NASH) is of great significance for public health and is faced with a major challenge. The activation of the thyroid hormone receptor agonist THRβ could be regulated by target drugs that has brought huge potential to the treatment of NASH. In this work, pyridazinone compound YWS01125 was synthesized for the first time. In this study, an ultra-performance liquid chromatography–tandem mass spectrometry (UPLC-MS/MS) method for YWS01125 determination was established, and the pharmacokinetics of YWS01125 was evaluated. The half-life values (t1/2)of three different doses of YWS01125 was 189.12 ± 95.27, 152.64 ± 37.98, and 181.95 ± 64.25 min, respectively, and the tissue distribution studies demonstrated that YWS01125 was quickly distributed to various tissues. With successful application in the pharmacokinetics study of YWS01125, the UPLC-MS/MS method has shown characteristics of high sensitivity, rapidity, and good selectivity.

Type of Medium: Online Resource

ISSN: 2296-2646

URL: Article

DOI: 10.3389/fchem.2022.888587

Language: Unknown

Publisher: Frontiers Media SA

Publication Date: 2022

detail.hit.zdb_id: 2711776-5

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First-in-man application of Liwen RF™ ablation system in the treatment of drug-resistant hypertrophic obstructive cardiomyopathy

Wang, Zihao ; Zhao, Rong ; Sievert, Horst ; [et al.]

Frontiers Media SA ; 2022

In: Frontiers in Cardiovascular Medicine Vol. 9 ( 2022-11-9)

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In: Frontiers in Cardiovascular Medicine, Frontiers Media SA, Vol. 9 ( 2022-11-9)

Abstract: This study sought to evaluate the clinical applicability of the Liwen Liu RF™ ablation system for percutaneous intramyocardial septal radiofrequency ablation (PIMSRA). Background Data on new cardiac radiofrequency ablation devices for the treatment of hypertrophic obstructive cardiomyopathy (HOCM) are limited. Materials and methods From July 2019 to July 2020, a total of 68 patients with drug-resistant HOCM, who underwent PIMSRA with the Liwen RF™ ablation system, which has an ablation electrode of stepless adjustable length, were prospectively enrolled. Safety endpoints included, amongst others, the occurrence of pericardial effusion and/or hemorrhage, cardiac arrhythmias, device failure and procedural death. The reduction in left ventricular outflow tract (LVOT) gradients at 12 months follow-up were used as a surrogate marker for device efficacy. Results All procedures were technically successful. The total energy output time of the system was 75.8 (IQR: 30.0) min, and the average power was 43.61 ± 13.34 watts. No ablation system error occurred. The incidence of pericardial effusion or hemorrhage, transient arrhythmia and resuscitation was 8.8, 39.7, and 1.5% during procedure, respectively. None of the patients died. During 30-day follow-up, there were no complications with the exception of a pericardial effusion in one patient (1.5%). No further complications were reported after 30 days. The patients’ resting [baseline: 75 (IQR: 48) vs. 12-months: 12 (IQR: 19) mmHg, p & lt; 0.001] and provoked [baseline: 122 (IQR: 53) vs. 12-months: 41 (IQR: 59) mmHg, p & lt; 0.001] LVOT gradients decreased significantly during follow-up. Conclusion In this study, we demonstrate the safety and feasibility of the Liwen RF™ ablation system to treat HOCM. The system allows for significant and sustainable LVOT gradient reduction during 12-months of follow-up. Hence, the Liwen RF™ ablation system is a promising new device that has the potential to become an alternative to existing septal reduction concepts in HOCM patients.

Type of Medium: Online Resource

ISSN: 2297-055X

URL: Article

DOI: 10.3389/fcvm.2022.1028763

Language: Unknown

Publisher: Frontiers Media SA

Publication Date: 2022

detail.hit.zdb_id: 2781496-8

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Data_Sheet_1.docx

Liu, Jiahui ; Fan, Fangfang ; Liu, Bo ; [et al.]

Frontiers Media SA ; 2022

In: Frontiers in Cardiovascular Medicine Vol. 9 ( 2022-11-11)

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In: Frontiers in Cardiovascular Medicine, Frontiers Media SA, Vol. 9 ( 2022-11-11)

Abstract: As a surrogate of arterial stiffness, the brachial-ankle pulse wave velocity (baPWV) is a good predictor of incident cardiovascular disease. Remnant cholesterol (RC) is a proven independent risk factor for cardiovascular disease. However, the relationship between RC and baPWV is unknown. The present study was performed to explore this relationship. Design Cross-sectional study. Setting and participants This study involved 8,028 participants of a community-based atherosclerosis cohort from China. Community residents aged ≥40 years were enrolled by responding to detailed research recruitment posters or by phone invitation. The participants comprised 2,938 (36.60%) men, and their mean age was 56.57 ± 9.04 years. Methods and results The baPWV was measured with a standard protocol using the Omron Colin BP-203RPE III device (Omron Healthcare, Kyoto, Japan). RC was calculated as follows: RC = TC – LDL-C – HDL-C. The mean baPWV was 1,646.85 ± 374.11 cm/s. The median RC concentration was 0.56 (0.41–0.74) mmol/L. In the multivariate logistic regression analyses, the concentrations of RC, triglycerides (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and non-high-density lipoprotein cholesterol (non-HDL-C) were all positively and independently associated with baPWV. The baPWV was higher in the fourth than first lipid profile quartile. The HDL-C concentration was inversely associated with baPWV. When RC was forced into the model with other lipid profile indices simultaneously, only the RC and TG concentrations remained significantly associated with baPWV. Conclusion Lipids are independently associated with baPWV. The RC and TG concentrations have stronger associations with arterial stiffness than other lipid indices in the Chinese community-based population.

Type of Medium: Online Resource

ISSN: 2297-055X

URL: Article

DOI: 10.3389/fcvm.2022.993097

DOI: 10.3389/fcvm.2022.993097.s001

Language: Unknown

Publisher: Frontiers Media SA

Publication Date: 2022

detail.hit.zdb_id: 2781496-8

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