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  • Frontiers Media SA  (437)
  • 1
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    DataSheet_1.pdf
    Frontiers Media SA ; 2023
    In:  Frontiers in Marine Science Vol. 10 ( 2023-1-30)
    Details
    In: Frontiers in Marine Science, Frontiers Media SA, Vol. 10 ( 2023-1-30)
    Abstract: Darkfield imaging can achieve in situ observation of marine plankton with unique advantages of high-resolution, high-contrast and colorful imaging for plankton species identification, size measurement and abundance estimation. However, existing underwater darkfield imagers have very shallow depth-of-field, leading to inefficient seawater sampling for plankton observation. We develop a data-driven method that can algorithmically refocus planktonic objects in their defocused darkfield images, equivalently achieving focus-extension for their acquisition imagers. We devise a set of dual-channel imaging apparatus to quickly capture paired images of live plankton with different defocus degrees in seawater samples, simulating the settings as in in situ darkfield plankton imaging. Through a series of registration and preprocessing operations on the raw image pairs, a dataset consisting of 55 000 pairs of defocused-focused plankter images have been constructed with an accurate defocus distance label for each defocused image. We use the dataset to train an end-to-end deep convolution neural network named IsPlanktonFE, and testify its focus-extension performance through extensive experiments. The experimental results show that IsPlanktonFE has extended the depth-of-field of a 0.5× darkfield imaging system to ~7 times of its original value. Moreover, the model has exhibited good content and instrument generalizability, and considerable accuracy improvement for a pre-trained ResNet-18 network to classify defocused plankton images. This focus-extension technology is expected to greatly enhance the sampling throughput and efficiency for the future in situ marine plankton observation systems, and promote the wide applications of darkfield plankton imaging instruments in marine ecology research and aquatic environment monitoring programs.
    Type of Medium: Online Resource
    ISSN: 2296-7745
    URL: Article
    URL: Article
    DOI: 10.3389/fmars.2023.1074428
    DOI: 10.3389/fmars.2023.1074428.s001
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2023
    detail.hit.zdb_id: 2757748-X
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  • 2
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    The Influence of Disabilities in Activities of Daily Living on Successful Aging: The Role of Well-Being and Residence Location
    Frontiers Media SA ; 2020
    In:  Frontiers in Public Health Vol. 7 ( 2020-1-28)
    Details
    In: Frontiers in Public Health, Frontiers Media SA, Vol. 7 ( 2020-1-28)
    Type of Medium: Online Resource
    ISSN: 2296-2565
    URL: Article
    DOI: 10.3389/fpubh.2019.00417
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2020
    detail.hit.zdb_id: 2711781-9
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  • 3
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    Table_3.docx
    Frontiers Media SA ; 2021
    In:  Frontiers in Oncology Vol. 10 ( 2021-1-7)
    Details
    In: Frontiers in Oncology, Frontiers Media SA, Vol. 10 ( 2021-1-7)
    Abstract: The Yes-associated protein (YAP1) is a main effector of the canonical Hippo pathway, which contributes greatly to tumor initiation, progression, and metastasis in multiple cancers, including gastric cancer (GC). Due to limited knowledge of YAP1 upregulation in cancer, it is a great challenge of therapeutic targets toward the Hippo–YAP1 pathway. Here, we identify nucleolar spindle-associated protein 1 (NUSAP1) as a novel binding partner of YAP1. The upregulation of NUSAP1 is associated with unfavorable clinical outcomes in GC patients, and NUSAP1 depletion impairs its oncogenic properties in vitro and in a xenograft model. Mechanistically, we discovered that NUSAP1 functions as a positive regulator of YAP1 protein stability, thereby inducing the transcription of Hippo pathway downstream target genes, such as CTGF and CYR61. More interestingly, we find that the cancer-promoting effects of NUSAP1 on GC cell growth, migration, and invasion are mainly mediated by YAP1. Furthermore, aberrant expression of NUSAP1 and YAP1 is highly correlated in GC cell lines and tissues. We herein clarify the role of the oncogenic NUSAP1–YAP1 axis in GC tumorigenesis and progression and, therefore, provide novel therapeutic targets for GC treatment.
    Type of Medium: Online Resource
    ISSN: 2234-943X
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    DOI: 10.3389/fonc.2020.591698
    DOI: 10.3389/fonc.2020.591698.s001
    DOI: 10.3389/fonc.2020.591698.s002
    DOI: 10.3389/fonc.2020.591698.s003
    DOI: 10.3389/fonc.2020.591698.s004
    DOI: 10.3389/fonc.2020.591698.s005
    DOI: 10.3389/fonc.2020.591698.s006
    DOI: 10.3389/fonc.2020.591698.s007
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2021
    detail.hit.zdb_id: 2649216-7
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  • 4
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    Corrigendum: NUSAP1 Promotes Gastric Cancer Tumorigenesis and Progression by Stabilizing the YAP1 Protein
    Frontiers Media SA ; 2021
    In:  Frontiers in Oncology Vol. 11 ( 2021-3-23)
    Details
    In: Frontiers in Oncology, Frontiers Media SA, Vol. 11 ( 2021-3-23)
    Type of Medium: Online Resource
    ISSN: 2234-943X
    URL: Article
    DOI: 10.3389/fonc.2021.666560
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2021
    detail.hit.zdb_id: 2649216-7
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  • 5
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    Inclusion Complex of Isoliquiritigenin With Sulfobutyl Ether-β-Cyclodextrin: Preparation, Characterization, Inclusion Mode, Solubilization, and Stability
    Frontiers Media SA ; 2022
    In:  Frontiers in Chemistry Vol. 10 ( 2022-6-21)
    Details
    In: Frontiers in Chemistry, Frontiers Media SA, Vol. 10 ( 2022-6-21)
    Abstract: Isoliquiritigenin (ISL) possesses a wide variety of pharmacological properties, however, its poor solubility and oral bioavailability pose a significant barrier to its application. In present studies, the ISL inclusion complex was prepared with sulfobutyl ether-β-cyclodextrin (SBE-β-CD). The physicochemical characterizations of ISL-SBE-β-CD were performed with Fourier transform infrared (FT-IR) spectroscopy and X-ray powder diffraction (XRD). Phase solubility study suggested a 1:1 formation of ISL-SBE-β-CD complexes. The water solubility of ISL rose from 13.6 μM to 4.05 mM by the inclusion of SBE-β-CD. The antioxidant activities (IC50) of ISL-SBE-β-CD reached 42.2 μg/ml, which was significantly lower than that of ISL (60.5 μg/ml). Its stability in biological environments was also enhanced.
    Type of Medium: Online Resource
    ISSN: 2296-2646
    URL: Article
    DOI: 10.3389/fchem.2022.930297
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2022
    detail.hit.zdb_id: 2711776-5
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  • 6
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    Table_1.docx
    Frontiers Media SA ; 2021
    In:  Frontiers in Nutrition Vol. 8 ( 2021-11-3)
    Details
    In: Frontiers in Nutrition, Frontiers Media SA, Vol. 8 ( 2021-11-3)
    Abstract: Background: The association between plasma vitamin E levels and first stroke risk in men and women remains unclear. Objective: We aimed to examine the prospective association between plasma vitamin E and first stroke, and evaluate the effect modifiers for the association, among hypertensive patients. Design: The study sample was drawn from the China Stroke Primary Prevention Trial (CSPPT), which randomized a total of 20,702 hypertensive patients to a double-blind, daily treatment with either 10 mg enalapril and 0.8 mg folic acid or 10 mg enalapril alone. This nested case-control study, including 618 first stroke cases and 618 controls matched for age, sex, treatment group, and study site, was conducted after the completion of the CSPPT. Results: The median follow-up duration was 4.5 years. Among men, a significantly higher risk of first stroke (adjusted OR, 1.67; 95%CI: 1.01, 2.77) was found for those with plasma vitamin E ≥7.1 μg/mL (≥quartile 1) compared with those with plasma vitamin E & lt; 7.1 μg/mL. Subgroup analyses further showed that the association between vitamin E (≥7.1 vs. & lt;7.1 μg/mL) and first stroke in men was significantly stronger in non-drinkers (adjusted OR, 2.64; 95%CI: 1.41, 4.96), compared to current drinkers (adjusted OR, 0.84; 95% CI: 0.43, 1.66, P -interaction = 0.008). However, there was no significant association between plasma vitamin E and first stroke in women ( P -interaction between sex and plasma vitamin E = 0.048). Conclusions: Among Chinese hypertensive patients, there was a statistically significant positive association between baseline plasma vitamin E and the risk of first stroke in men, but not in women. Clinical Trial Registration: https://clinicaltrials.gov/ct2/show/NCT00794885 , Identifier: NCT00794885.
    Type of Medium: Online Resource
    ISSN: 2296-861X
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    DOI: 10.3389/fnut.2021.734580
    DOI: 10.3389/fnut.2021.734580.s001
    DOI: 10.3389/fnut.2021.734580.s002
    DOI: 10.3389/fnut.2021.734580.s003
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2021
    detail.hit.zdb_id: 2776676-7
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  • 7
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    Non-enhanced magnetic resonance imaging-based radiomics model for the differentiation of pancreatic adenosquamous carcinoma from pancreatic ductal adenocarcinoma
    Frontiers Media SA ; 2023
    In:  Frontiers in Oncology Vol. 13 ( 2023-1-23)
    Details
    In: Frontiers in Oncology, Frontiers Media SA, Vol. 13 ( 2023-1-23)
    Abstract: To evaluate the diagnostic performance of radiomics model based on fully automatic segmentation of pancreatic tumors from non-enhanced magnetic resonance imaging (MRI) for differentiating pancreatic adenosquamous carcinoma (PASC) from pancreatic ductal adenocarcinoma (PDAC). Materials and methods In this retrospective study, patients with surgically resected histopathologically confirmed PASC and PDAC who underwent MRI scans between January 2011 and December 2020 were included in the study. Multivariable logistic regression analysis was conducted to develop a clinical and radiomics model based on non-enhanced T1-weighted and T2-weighted images. The model performances were determined based on their discrimination and clinical utility. Kaplan-Meier and log-rank tests were used for survival analysis. Results A total of 510 consecutive patients including 387 patients (age: 61 ± 9 years; range: 28–86 years; 250 males) with PDAC and 123 patients (age: 62 ± 10 years; range: 36–84 years; 78 males) with PASC were included in the study. All patients were split into training (n=382) and validation (n=128) sets according to time. The radiomics model showed good discrimination in the validation (AUC, 0.87) set and outperformed the MRI model (validation set AUC, 0.80) and the ring-enhancement (validation set AUC, 0.74). Conclusions The radiomics model based on non-enhanced MRI outperformed the MRI model and ring-enhancement to differentiate PASC from PDAC; it can, thus, provide important information for decision-making towards precise management and treatment of PASC.
    Type of Medium: Online Resource
    ISSN: 2234-943X
    URL: Article
    DOI: 10.3389/fonc.2023.1108545
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2023
    detail.hit.zdb_id: 2649216-7
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  • 8
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    Image_4.png
    Frontiers Media SA ; 2022
    In:  Frontiers in Plant Science Vol. 13 ( 2022-6-27)
    Details
    In: Frontiers in Plant Science, Frontiers Media SA, Vol. 13 ( 2022-6-27)
    Abstract: Nitrogen is one of the most important nutrient elements required for plant growth and development, which is also immensely related to the efficient use of nitrogen by crop plants. Therefore, plants evolved sophisticated mechanisms and anion channels to extract inorganic nitrogen (nitrate) from the soil or nutrient solutions, assimilate, and recycle the organic nitrogen. Hence, developing crop plants with a greater capability of using nitrogen efficiently is the fundamental research objective for attaining better agricultural productivity and environmental sustainability. In this context, an in-depth investigation has been conducted into the cassava slow type anion channels ( SLAHs ) gene family, including genome-wide expression analysis, phylogenetic relationships with other related organisms, chromosome localization, and functional analysis. A potential and nitrogen-responsive gene of cassava ( MeSLAH4 ) was identified and selected for overexpression (OE) analysis in rice, which increased the grain yield and root growth related performance. The morpho-physiological response of OE lines was better under low nitrogen (0.01 mm NH 4 NO 3 ) conditions compared to the wild type (WT) and OE lines under normal nitrogen (0.5 mm NH 4 NO 3 ) conditions. The relative expression of the MeSLAH4 gene was higher (about 80-fold) in the OE line than in the wild type. The accumulation and flux assay showed higher accumulation of NO 3 − and more expansion of root cells and grain dimension of OE lines compared to the wild type plants. The results of this experiment demonstrated that the MeSLAH4 gene may play a vital role in enhancing the efficient use of nitrogen in rice, which could be utilized for high-yielding crop production.
    Type of Medium: Online Resource
    ISSN: 1664-462X
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    DOI: 10.3389/fpls.2022.932947
    DOI: 10.3389/fpls.2022.932947.s001
    DOI: 10.3389/fpls.2022.932947.s002
    DOI: 10.3389/fpls.2022.932947.s003
    DOI: 10.3389/fpls.2022.932947.s004
    DOI: 10.3389/fpls.2022.932947.s005
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2022
    detail.hit.zdb_id: 2687947-5
    detail.hit.zdb_id: 2613694-6
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  • 9
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    Table_1.DOCX
    Frontiers Media SA ; 2021
    In:  Frontiers in Veterinary Science Vol. 8 ( 2021-5-12)
    Details
    In: Frontiers in Veterinary Science, Frontiers Media SA, Vol. 8 ( 2021-5-12)
    Abstract: There is a growing interest in the use of yeast ( Saccharomyces cerevisiae ) culture (YC) for the enhancement of growth performance and general animal health. Grain-based pelleted total mixed rations (TMR) are emerging in intensive sheep farming systems, but it is uncertain if the process of pelleting results in YC becoming ineffective. This study aimed to examine the effects of YC supplemented to pelleted TMR at two proportions of corn in the diet on animal performance, feed digestion, blood parameters, rumen fermentation, and microbial community in fattening lambs. A 2 × 2 factorial design was adopted with two experimental factors and two levels in each factor, resulting in four treatments: (1) low proportion of corn in the diet (LC; 350 g corn/kg diet) without YC, (2) LC with YC (5 g/kg diet), (3) high proportion of corn in the diet (HC; 600 g corn/kg diet) without YC, and (4) HC with YC. Fifty-six 3-month-old male F2 hybrids of thin-tailed sheep and Northeast fine-wool sheep with a liveweight of 19.9 ± 2.7 kg were randomly assigned to the four treatment groups with an equal number of animals in each group. The results showed that live yeast cells could not survive during pelleting, and thus, any biological effects of the YC were the result of feeding dead yeast and the metabolites of yeast fermentation rather than live yeast cells. The supplementation of YC resulted in 31.1 g/day more average daily gain regardless of the proportion of corn in the diet with unchanged feed intake during the 56-day growth measurement period. The digestibility of neutral detergent fibre and acid detergent fibre was increased, but the digestibility of dry matter, organic matter, and crude protein was not affected by YC. The supplementation of YC altered the rumen bacterial population and species, but the most abundant phyla Bacteroidetes, Firmicutes , and Proteobacteria remained unchanged. This study indicates that YC products can be supplemented to pelleted TMR for improved lamb growth performance, although live yeast cells are inactive after pelleting. The improved performance could be attributed to improved fibre digestibility.
    Type of Medium: Online Resource
    ISSN: 2297-1769
    URL: Article
    URL: Article
    DOI: 10.3389/fvets.2021.657816
    DOI: 10.3389/fvets.2021.657816.s001
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2021
    detail.hit.zdb_id: 2834243-4
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  • 10
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    Supplementation of graded levels of rumen-protected choline to a pelleted total mixed ration did not improve the growth and slaughter performance of fattening lambs
    Frontiers Media SA ; 2022
    In:  Frontiers in Veterinary Science Vol. 9 ( 2022-11-23)
    Details
    In: Frontiers in Veterinary Science, Frontiers Media SA, Vol. 9 ( 2022-11-23)
    Abstract: Choline is an essential nutrient in ruminant diets, which contributes to the fundamental biological functions of the animal. However, choline is easily degraded in the rumen before it can be absorbed. Rumen-protected choline (RPC) supplementation might support the fast growth of ruminants. This study aimed to investigate the effects of supplementing graded levels of RPC in a pelleted total mixed ration for fattening lambs. Sixty three-month-old male Small Tail Han and northeast fine wool sheep hybrid lambs with a liveweight of 15.3 ± 1.8 kg (mean ± SD) were fed designated diets and randomly assigned into five treatment groups ( n = 12 per group). The five treatments were the rate of RPC supplementation at 0, 1.25, 2.50, 3.75, and 5.00 g (equivalent to 0, 0.31, 0.63, 0.94, and 1.25 g of choline chloride, respectively)/kg basal diet and the RPC-supplemented feed was offered for 112 days after 12 days of adaptation. Average daily gain, dry matter intake, and nutrient digestibility were similar across treatments. The rumen pH was quadratically significant among treatments, with the lowest and highest pH observed from the 2.5 and 5 g/kg RPC supplement groups, respectively ( P = 0.02). After feeding, the ruminal ammonia concentrations among treatments were different ( P & lt; 0.05), with the highest value observed from the 5 g/kg RPC supplement group. Microbial crude protein level was different, with the highest value recorded from the 0 g/kg RPC supplement group ( P = 0.028). A linear effect ( P & lt; 0.05) was observed from short-chain fatty acid values among treatments before and after feeding. Serum albumin ( P = 0.003) and albumin/globulin ratio ( P = 0.002) had a quadratic effect, with the highest value found in the 0 g/kg RPC supplement group. Abdominal fat was higher in RPC-supplemented groups ( P & lt; 0.05) compared to the control group. Drip loss was 65% higher in RPC-supplemented groups compared to the control group ( P = 0.012). Overall, the study results showed an effect of RPC on ruminal parameters, but the supplementation of low-level RPC did not improve the growth and slaughter performance of fattening lambs.
    Type of Medium: Online Resource
    ISSN: 2297-1769
    URL: Article
    DOI: 10.3389/fvets.2022.1034895
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2022
    detail.hit.zdb_id: 2834243-4
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