GLORIA

GEOMAR Library Ocean Research Information Access

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
  • Frontiers Media SA  (4)
Material
Publisher
  • Frontiers Media SA  (4)
Language
Years
  • 1
    Online Resource
    Online Resource
    Frontiers Media SA ; 2022
    In:  Frontiers in Microbiology Vol. 13 ( 2022-12-12)
    In: Frontiers in Microbiology, Frontiers Media SA, Vol. 13 ( 2022-12-12)
    Abstract: Yinchen Linggui Zhugan decoction (YLZD) is an effective and classical traditional herbal prescription for treating the nonalcoholic fatty liver disease (NAFLD) and has been proven to be effective in the regulation of lipid metabolism disorder and attenuate inflammation for a NAFLD rat model. However, the exact underlying mechanism has not been elucidated. In the current study, a NAFLD rat model was established using a high-fat diet (HFD) for 10 weeks, followed by YLZD treatment with 1.92 g/kg/day for 4 weeks to explore the mechanisms of YLZD. Our results showed that YLZD decreased the hepatic lipid deposition, restored the liver tissue pathological lesions, inhibited the expression of oxidative stress, and decreased the inflammatory cytokines levels. Meanwhile, the genes and proteins expressions of SIRT1/Nrf2 signaling pathway together with downstream factors including HO-1 and NQO1 were elevated in the YLZD treated NAFLD rats. For further elaborating the upstream mechanism, short-chain fatty acids (SCFAs) in serum and feces were measured by liquid chromatograph mass spectrometer and gas chromatograph mass spectrometer, and the differences in gut microbiota of rats in each group were analyzed through high-throughput sequencing of 16S rRNA. The results demonstrated that the contents of butyric acid (BA) and total SCFAs in YLZD-treated NAFLD rats were significantly increased in serum and feces. 16S rRNA sequencing analysis illustrated that YLZD intervention led to a modification of the gut microbiota composition, with a decrease of Oribacterium , Lactobacillus and the ratio of Firmicutes/Bacteroides , as well as the increase in SCFAs-producing bacteria such as Christensenellaceae , Clostridia , Muribaculaceae , and Prevotellaceae . Spearman rank correlation analysis indicated that BA and total SCFAs were negatively co-related with oxidative stress-related factors and inflammatory cytokines, while they were positively co-related with SIRT1/Nrf2 pathway related genes and proteins. Furthermore, in vitro study confirmed that BA effectively reduced oxidative stress by activating SIRT1/Nrf2 signaling pathway in L02 cells. Together, the present data revealed YLZD could ameliorate HFD-induced NAFLD in rats by the modulation of SIRT1/Nrf2 signaling pathway and gut microbiota.
    Type of Medium: Online Resource
    ISSN: 1664-302X
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2022
    detail.hit.zdb_id: 2587354-4
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
  • 2
    In: Frontiers in Earth Science, Frontiers Media SA, Vol. 10 ( 2022-8-22)
    Abstract: The Little Ice Age (LIA) during the Ming and Qing dynasties was the most abnormal climate event in China for nearly 2,000 years. During this period, the climate was relatively cold and various natural disasters frequently took place. By locating and compiling related historical documents, we aimed to quantitatively and systematically analyze the spatial–temporal variations in the natural disasters in the ancient Huizhou region (hereinafter referred to as Huizhou region or Huizhou) during the Ming and Qing dynasties (1368–1911; all dates are in AD, unless otherwise mentioned). The results show that (1) flood and drought disasters, the major types of disasters in this area during the Ming and Qing dynasties, occurred 422 times, accounting for 79.6% of the natural disasters, (2) there was a significant correlation of occurrence frequency of flood plus drought disasters and the total natural disasters on a certain time scale. In addition to flood and drought disasters, other disasters (hailstorms, windstorms, frosts, and earthquakes) occurred more frequently in the Qing dynasty (1644–1911) than in the Ming dynasty (1368–1644). The occurrence frequency of natural disasters had a fluctuant variation pattern over time, with peaks emerging about once a century. The peaks of natural disasters were mainly concentrated at 1471–1490, 1571–1590, 1671–1690, 1751–1770, and 1851–1870, which is supported by the wavelet analysis, (3) the most frequent natural disasters took place in Wuyuan, followed by Jixi, Shexian, Xiuning, Qimen, and Yixian. More droughts occurred in Jixi and Yixian, while more floods occurred in Wuyuan, Shexian, and Qimen, more hailstorms occurred in Wuyuan and Jixi, more frost disasters occurred in Wuyuan, Jixi, and Qimen, and more earthquakes occurred in Wuyuan and Jixi. The occurrence frequency of wind disasters was not high in any of the counties, (4) flood and drought disasters in the Huizhou region exhibited obvious stage characteristics during the Ming and Qing dynasties, and they changed gradually from droughts to floods, among which the transition from slight drought to slight flooding was the most obvious during 1811–1911, and (5) overall, slight flooding and slight drought situations accounted for the largest percentage of drought and flood disasters in this area during the Ming and Qing dynasties. Among these, slight flooding mainly occurred in Shexian and Qimen; severe flooding mainly occurred in Wuyuan; slight drought mainly occurred in Yixian; and severe drought mainly occurred in Jixi.
    Type of Medium: Online Resource
    ISSN: 2296-6463
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2022
    detail.hit.zdb_id: 2741235-0
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
  • 3
    Online Resource
    Online Resource
    Frontiers Media SA ; 2021
    In:  Frontiers in Surgery Vol. 8 ( 2021-10-8)
    In: Frontiers in Surgery, Frontiers Media SA, Vol. 8 ( 2021-10-8)
    Abstract: Background: It is common for patients with gastric cancer to develop distant metastases in the liver, lung, bone, and brain. Although the thyroid also has an abundant blood supply, gastric cancer metastasis to the thyroid is uncommon. Due to the rarity of such metastasis, its clinical features are not well understood. Here, we present the case of a patient with gastric cancer metastasis to the thyroid treated at our hospital. Case Summary: We report the case of a 63-year-old female with a mass in the anterior neck and mild hoarseness for 6 months. The patient underwent proximal subtotal gastrectomy for Siewert III oesophagogastric junction cancer 6 years ago. Subsequently, she received 8 cycles of adjuvant chemotherapy. Her condition was stable until mild hoarseness developed for no apparent reason 6 months prior to presenting at our clinic. Both ultrasonography and computed tomography confirmed a heterogeneous mass in the right lobe of the thyroid gland. Blood thyroid function tests and tumor marker expression levels were normal. Thyroid malignancy was suspected, and the patient underwent a right thyroidectomy. During the surgery, a tumor was found that had invaded the right recurrent laryngeal nerve and trachea. H & amp;E staining and immunohistochemistry results suggested that the cancer cells originated from gastric cancer. The patient was diagnosed with thyroid metastasis of gastric cancer. She refused further treatment and died within 6 months. Conclusion: Metastasis of gastric cancer to the thyroid is rare and is associated with a poor prognosis. Immunohistochemical diagnosis is essential for a conclusive diagnosis. For patients with a history of malignant tumors, the possibility of metastatic thyroid nodules should be ruled out when diagnosing thyroid nodules.
    Type of Medium: Online Resource
    ISSN: 2296-875X
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2021
    detail.hit.zdb_id: 2773823-1
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
  • 4
    Online Resource
    Online Resource
    Frontiers Media SA ; 2022
    In:  Frontiers in Physics Vol. 10 ( 2022-4-27)
    In: Frontiers in Physics, Frontiers Media SA, Vol. 10 ( 2022-4-27)
    Abstract: Nonlinear generation and manipulation of vortex beams have emerged as a research hot topic in recent years. During nonlinear frequency conversions, orbital angular momentum will transfer from the fundamental wave to harmonic waves. In this work, we study theoretically the backward optical parametric oscillator pumped by vortex beams. The orbital angular momentum conservation law has been disclosed for the counter propagation nonlinear process. In addition, the oscillation threshold and the conversion efficiency have been investigated in detail. Our results will be helpful for the experimental demonstration of backward optical parametric oscillator pumped by vortex beams.
    Type of Medium: Online Resource
    ISSN: 2296-424X
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2022
    detail.hit.zdb_id: 2721033-9
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...