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  • 1
    Online Resource
    Online Resource
    Table_1.pdf
    Frontiers Media SA ; 2021
    In:  Frontiers in Cardiovascular Medicine Vol. 8 ( 2021-11-2)
    Details
    In: Frontiers in Cardiovascular Medicine, Frontiers Media SA, Vol. 8 ( 2021-11-2)
    Abstract: Aquatic exercise is an attractive form of exercise that utilizes the various properties of water to improve physical health, including arterial stiffness. However, it is unclear whether regular head-out aquatic exercise affects aortic hemodynamics, the emerging risk factors for future cardiovascular disease. The purpose of this study was to investigate whether head-out aquatic exercise training improves aortic hemodynamics in middle-aged and elderly people. In addition, to shed light on the underlying mechanisms, we determined the contribution of change in arterial stiffness to the hypothesized changes in aortic hemodynamics. Twenty-three middle-aged and elderly subjects (62 ± 9 years) underwent a weekly aquatic exercise course for 15 weeks. Aortic hemodynamics were evaluated by pulse wave analysis via the general transfer function method. Using a polar coordinate description, companion metrics of aortic pulse pressure (PPC = √{(systolic blood pressure) 2 + (diastolic blood pressure) 2 }) and augmentation index (AIxC = √{(augmentation pressure) 2 + (pulse pressure) 2 }) were calculated as measures of arterial load. Brachial-ankle (baPWV, reflecting stiffness of the abdominal aorta and leg artery) and heart-ankle (haPWV, reflecting stiffness of the whole aortic and leg artery) pulse wave velocities were also measured. The rate of participation in the aquatic training program was 83.5 ± 13.0%. Aortic systolic blood pressure, pulse pressure, PPC, AIxC, baPWV, and haPWV decreased after the training ( P & lt; 0.05 for all), whereas augmentation index remained unchanged. Changes in aortic SBP were correlated with changes in haPWV ( r = 0.613, P = 0.002) but not baPWV ( r = 0.296, P = 0.170). These findings suggest that head-out aquatic exercise training may improve aortic hemodynamics in middle-aged and elderly people, with the particular benefits for reducing aortic SBP which is associated with proximal aortic stiffness.
    Type of Medium: Online Resource
    ISSN: 2297-055X
    URL: Article
    URL: Article
    DOI: 10.3389/fcvm.2021.770519
    DOI: 10.3389/fcvm.2021.770519.s001
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2021
    detail.hit.zdb_id: 2781496-8
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  • 2
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    Exercise in Water Provides Better Cardiac Energy Efficiency Than on Land
    Frontiers Media SA ; 2021
    In:  Frontiers in Cardiovascular Medicine Vol. 8 ( 2021-12-13)
    Details
    In: Frontiers in Cardiovascular Medicine, Frontiers Media SA, Vol. 8 ( 2021-12-13)
    Abstract: Although water-based exercise is one of the most recommended forms of physical activity, little information is available regarding its influence on cardiac workload and myocardial oxygen supply-to-demand. To address this question, we compared subendocardial viability ratio (SEVR, the ratio of myocardial oxygen supply-to-demand), cardiac inotropy ( via the maximum rate of aortic pressure rise [dP/dT max ]), and stroke volume (SV, via a Modelflow method) responses between water- and land-based exercise. Eleven healthy men aged 24 ± 1 years underwent mild- to moderate-intensity cycling exercise in water (WC) and on land (LC) consecutively on separate days. In WC, cardiorespiratory variables were monitored during leg cycling exercise (30, 45, and 60 rpm of cadence for 5 min each) using an immersible stationary bicycle. In LC, each participant performed a cycling exercise at the oxygen consumption (VO 2 ) matched to the WC. SEVR and dP/dT max were obtained by using the pulse wave analysis from peripheral arterial pressure waveforms. With increasing exercise intensity, SEVR exhibited similar progressive reductions in WC (from 211 ± 44 to 75 ± 11%) and LC (from 215 ± 34 to 78 ± 9%) (intensity effect: P & lt; 0.001) without their conditional differences. WC showed higher SV at rest and a smaller increase in SV than LC (environment-intensity interaction: P = 0.009). The main effect of environment on SV was significant ( P = 0.002), but that of dP/dT max was not ( P = 0.155). SV was correlated with dP/dT max ( r = 0.717, P & lt; 0.001). When analysis of covariance (ANCOVA) was performed with dP/dT max as a covariate, the environment effect on SV was still significant ( P & lt; 0.001), although environment-intensity interaction was abolished ( P = 0.543). These results suggest that water-based exercise does not elicit unfavorable myocardial oxygen supply-to-demand balance at mild-to-moderate intensity compared with land-based exercise. Rather, water-based exercise may achieve higher SV and better myocardial energy efficiency than land-based exercise, even at the same inotropic force.
    Type of Medium: Online Resource
    ISSN: 2297-055X
    URL: Article
    DOI: 10.3389/fcvm.2021.747841
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2021
    detail.hit.zdb_id: 2781496-8
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  • 3
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    DataSheet2.pdf
    Frontiers Media SA ; 2022
    In:  Frontiers in Molecular Biosciences Vol. 9 ( 2022-8-25)
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    In: Frontiers in Molecular Biosciences, Frontiers Media SA, Vol. 9 ( 2022-8-25)
    Abstract: Co-translational protein folding is one of the central topics in molecular biology. In Escherichia coli , trigger factor (TF) is a primary chaperone that facilitates co-translational folding by directly interacting with nascent polypeptide chains on translating ribosomes. In this study, we applied fluorescence correlation spectroscopy (FCS), which can analyze the diffusion properties of fluorescent molecules by measuring the fluctuations of the fluorescent intensity, to investigate the interaction between TF and a nascent chain on translating ribosomes both in vitro and in vivo . The FCS analysis with a reconstituted cell-free translation system revealed that the interaction of fluorescently labeled TF with a nascent chain depended on the emergence of the nascent chain from the ribosome exit tunnel, and this interaction was not inhibited by excess amounts of other chaperones. Furthermore, the translation-dependent interaction between GFP-fused TFs and nascent chains was also observed in living E. coli cells. The FCS-based approach established here could be an effective method to investigate the dynamics of other ribosome-associated chaperones besides TF.
    Type of Medium: Online Resource
    ISSN: 2296-889X
    URL: Article
    URL: Article
    URL: Article
    DOI: 10.3389/fmolb.2022.891128
    DOI: 10.3389/fmolb.2022.891128.s001
    DOI: 10.3389/fmolb.2022.891128.s002
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2022
    detail.hit.zdb_id: 2814330-9
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  • 4
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    Image_2.JPEG
    Frontiers Media SA ; 2022
    In:  Frontiers in Medicine Vol. 9 ( 2022-10-28)
    Details
    In: Frontiers in Medicine, Frontiers Media SA, Vol. 9 ( 2022-10-28)
    Abstract: Early renal function after living-donor kidney transplantation (LDKT) depends on the “nephron mass” in the renal graft. In this study, as a possible donor-recipient size mismatch parameter that directly reflects the “nephron mass,” the cortex to recipient weight ratio (CRWR) was calculated by CT-volumetric software, and its ability to predict early graft function was examined. One hundred patients who underwent LDKT were enrolled. Patients were classified into a developmental cohort ( n = 79) and a validation cohort ( n = 21). Using the developmental cohort, the correlation coefficients between size mismatch parameters, including CRWR, and the posttransplantation estimated glomerular filtration rate (eGFR) were calculated. Multiple regression analysis was conducted to define a formula to predict eGFR 1-month posttransplantation. Using the validation cohort, the validity of the formula was examined. The correlation coefficient was the highest for CRWR (1-month r = 0.66, p & lt; 0.001). By multiple regression analysis, eGFR at 1-month was predicted using the linear model: 0.23 × donor preoperative eGFR + 17.03 × CRWR + 8.96 × preemptive transplantation + 5.10 (adjusted coefficient of determination = 0.54). In most patients in the validation cohort, the observed eGFR was within a 10 ml/min/1.73 m 2 margin of the predicted eGFR. CRWR was the strongest parameter to predict early graft function. Predicting renal function using this formula could be useful in clinical application to select proper donors and to avoid unnecessary postoperative medical interventions.
    Type of Medium: Online Resource
    ISSN: 2296-858X
    URL: Article
    URL: Article
    URL: Article
    DOI: 10.3389/fmed.2022.1007175
    DOI: 10.3389/fmed.2022.1007175.s001
    DOI: 10.3389/fmed.2022.1007175.s002
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2022
    detail.hit.zdb_id: 2775999-4
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