In:
Frontiers in Immunology, Frontiers Media SA, Vol. 14 ( 2023-8-14)
Abstract:
Interferon-gamma (IFN-γ), commonly referred to as type II interferon, is a crucial cytokine that coordinates the tumor immune process and has received considerable attention in tumor immunotherapy research. Previous studies have discussed the role and mechanisms associated with IFN-γ in specific tumors or diseases, but the relevant role of IFN-γ in pan-cancer remains uncertain. Methods TCGA and GTEx RNA expression data and clinical data were downloaded. Additionally, we analyzed the role of IFN-γ on tumors by using a bioinformatic approach, which included the analysis of the correlation between IFN-γ in different tumors and expression, prognosis, functional status, TMB, MSI, immune cell infiltration, and TIDE. We also developed a PPI network for topological analysis of the network, identifying hub genes as those having a degree greater than IFN-γ levels. Result IFN-γ was differentially expressed and predicted different survival statuses in a majority of tumor types in TCGA. Additionally, IFN-γ expression was strongly linked to factors like infiltration of T cells, immune checkpoints, immune-activating genes, immunosuppressive genes, chemokines, and chemokine receptors, as well as tumor purity, functional statuses, and prognostic value. Also, prognosis, CNV, and treatment response were all substantially correlated with IFN-γ-related gene expression. Particularly, the IFN-γ-related gene STAT1 exhibited the greatest percentage of SNVs and the largest percentage of SNPs in UCEC. Elevated expression levels of IFN-γ-related genes were found in a wide variety of tumor types, and this was shown to be positively linked to drug sensitivity for 20 different types of drugs. Conclusion IFN-γ is a good indicator of response to tumor immunotherapy and is likely to limit tumor progression, offering a novel approach for immunotherapy’s future development.
Type of Medium:
Online Resource
ISSN:
1664-3224
DOI:
10.3389/fimmu.2023.1202150
DOI:
10.3389/fimmu.2023.1202150.s001
DOI:
10.3389/fimmu.2023.1202150.s002
DOI:
10.3389/fimmu.2023.1202150.s003
DOI:
10.3389/fimmu.2023.1202150.s004
DOI:
10.3389/fimmu.2023.1202150.s005
DOI:
10.3389/fimmu.2023.1202150.s006
DOI:
10.3389/fimmu.2023.1202150.s007
DOI:
10.3389/fimmu.2023.1202150.s008
DOI:
10.3389/fimmu.2023.1202150.s009
DOI:
10.3389/fimmu.2023.1202150.s010
DOI:
10.3389/fimmu.2023.1202150.s011
Language:
Unknown
Publisher:
Frontiers Media SA
Publication Date:
2023
detail.hit.zdb_id:
2606827-8
Permalink