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  • Frontiers Media SA  (4)
  • 1
    Online Resource
    Online Resource
    Data_Sheet_2.DOCX
    Frontiers Media SA ; 2022
    In:  Frontiers in Medicine Vol. 9 ( 2022-10-4)
    Details
    In: Frontiers in Medicine, Frontiers Media SA, Vol. 9 ( 2022-10-4)
    Abstract: Erector spinae plane block (ESPB) has been used for many thoracic and abdominal surgeries. However, evidence of its analgesic efficacy following abdominal surgery, compared with that of thoracic analgesia, is insufficient. Our study explored the analgesic effect of ESPB after abdominal surgery. Methods We searched PubMed, Embase, Cochrane Central Register of Controlled Trials, and ClinicalTrials.gov. Primary outcomes were pain scores at 6, 12 and 24 h and 24-h opioid consumption. Secondary outcomes included time to first rescue analgesia, length of hospital stay, and incidence of postoperative nausea and vomiting (PONV). We calculated standardized mean differences (SMDs) with 95% confidence intervals (CIs) for primary outcomes and mean differences (MDs) and risk ratios (RRs) with 95% CIs for secondary outcomes. Results We systematically included 1,502 cases in 24 trials. Compared with placebo, ESPB significantly reduced pain scores at 6 h (SMD −1.25; 95% CI −1.79 to −0.71), 12 h (SMD −0.85; 95% CI −1.33 to −0.37) and 24 h (SMD −0.84; 95% CI −1.30 to −0.37) and 24-h opioid consumption (SMD −0.62; 95% CI −1.19 to −0.06) post-surgery. ESPB prolonged the time to first rescue analgesia and decreased the incidence of PONV. Compared with transversus abdominal plane block (TAPB), ESPB significantly reduced pain scores at 6, 12, and 24 h and 24-h opioid consumption and prolonged the time to first rescue analgesia postsurgically. Furthermore, subgroup analysis showed that ESPB significantly reduced pain scores at various time points and opioid consumption within 24 h after laparoscopic cholecystectomy, percutaneous nephrolithotomy and bariatric surgery. Conclusion Compared with placebo, ESPB improves the postoperative analgesic efficacy after abdominal surgery. Furthermore, our meta-analysis confirmed that ESPB provides more beneficial analgesic efficacy than TAPB. Systematic review registration [ https://www.crd.york.ac.uk/PROSPEROFILES/301491_STRATEGY_20220104.pdf ], identifier [CRD42022301491] .
    Type of Medium: Online Resource
    ISSN: 2296-858X
    URL: Article
    URL: Article
    URL: Article
    DOI: 10.3389/fmed.2022.934866
    DOI: 10.3389/fmed.2022.934866.s001
    DOI: 10.3389/fmed.2022.934866.s002
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2022
    detail.hit.zdb_id: 2775999-4
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  • 2
    Online Resource
    Online Resource
    DataSheet_7.xlsx
    Frontiers Media SA ; 2024
    In:  Frontiers in Immunology Vol. 15 ( 2024-4-18)
    Details
    In: Frontiers in Immunology, Frontiers Media SA, Vol. 15 ( 2024-4-18)
    Abstract: Several observational studies have proposed a potential link between gut microbiota and the onset and progression of sepsis. Nevertheless, the causality of gut microbiota and sepsis remains debatable and warrants more comprehensive exploration. Methods We conducted a two-sample Mendelian randomization (MR) analysis to test the causality between gut microbiota and the onset and progression of sepsis. The genome-wide association study (GWAS) summary statistics for 196 bacterial traits were extracted from the MiBioGen consortium, whereas the GWAS summary statistics for sepsis and sepsis-related outcomes came from the UK Biobank. The inverse-variance weighted (IVW) approach was the primary method used to examine the causal association. To complement the IVW method, we utilized four additional MR methods. We performed a series of sensitivity analyses to examine the robustness of the causal estimates. Results We assessed the causality of 196 bacterial traits on sepsis and sepsis-related outcomes. Genus Coprococcus2 [odds ratio (OR) 0.81, 95% confidence interval (CI) (0.69–0.94), p = 0.007] and genus Dialister (OR 0.85, 95% CI 0.74–0.97, p = 0.016) had a protective effect on sepsis, whereas genus Ruminococcaceae UCG011 (OR 1.10, 95% CI 1.01–1.20, p = 0.024) increased the risk of sepsis. When it came to sepsis requiring critical care, genus Anaerostipes (OR 0.49, 95% CI 0.31–0.76, p = 0.002), genus Coprococcus1 (OR 0.65, 95% CI 0.43–1.00, p = 0.049), and genus Lachnospiraceae UCG004 (OR 0.51, 95% CI 0.34–0.77, p = 0.001) emerged as protective factors. Concerning 28-day mortality of sepsis, genus Coprococcus1 (OR 0.67, 95% CI 0.48–0.94, p = 0.020), genus Coprococcus2 (OR 0.48, 95% CI 0.27–0.86, p = 0.013), genus Lachnospiraceae FCS020 (OR 0.70, 95% CI 0.52–0.95, p = 0.023), and genus Victivallis (OR 0.82, 95% CI 0.68–0.99, p = 0.042) presented a protective effect, whereas genus Ruminococcus torques group (OR 1.53, 95% CI 1.00–2.35, p = 0.049), genus Sellimonas (OR 1.25, 95% CI 1.04–1.50, p = 0.019), and genus Terrisporobacter (OR 1.43, 95% CI 1.02–2.02, p = 0.040) presented a harmful effect. Furthermore, genus Coprococcus1 (OR 0.42, 95% CI 0.19–0.92, p = 0.031), genus Coprococcus2 (OR 0.34, 95% CI 0.14–0.83, p = 0.018), and genus Ruminiclostridium6 (OR 0.43, 95% CI 0.22–0.83, p = 0.012) were associated with a lower 28-day mortality of sepsis requiring critical care. Conclusion This MR analysis unveiled a causality between the 21 bacterial traits and sepsis and sepsis-related outcomes. Our findings may help the development of novel microbiota-based therapeutics to decrease the morbidity and mortality of sepsis.
    Type of Medium: Online Resource
    ISSN: 1664-3224
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    DOI: 10.3389/fimmu.2024.1266579
    DOI: 10.3389/fimmu.2024.1266579.s001
    DOI: 10.3389/fimmu.2024.1266579.s002
    DOI: 10.3389/fimmu.2024.1266579.s003
    DOI: 10.3389/fimmu.2024.1266579.s004
    DOI: 10.3389/fimmu.2024.1266579.s005
    DOI: 10.3389/fimmu.2024.1266579.s006
    DOI: 10.3389/fimmu.2024.1266579.s007
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2024
    detail.hit.zdb_id: 2606827-8
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  • 3
    Online Resource
    Online Resource
    Effect of atrial fibrillation on outcomes in patients with anterior circulation occlusion stroke receiving endovascular therapy
    Frontiers Media SA ; 2023
    In:  Frontiers in Aging Neuroscience Vol. 15 ( 2023-6-15)
    Details
    In: Frontiers in Aging Neuroscience, Frontiers Media SA, Vol. 15 ( 2023-6-15)
    Abstract: Atrial fibrillation is one of the major risk factors of ischemic stroke. Endovascular thrombectomy (EVT) has become the standard treatment for acute ischemic stroke with large vessel occlusion. However, data regarding the impact of AF on the outcome of patients with acute ischemic stroke treated with mechanical thrombectomy are controversial. The aim of our study was to determine whether atrial fibrillation modifies the functional outcome of patients with anterior circulation acute ischemic stroke receiving EVT. Methods We reviewed 273 eligible patients receiving EVT from January 2019 to January 2022 from 3 comprehensive Chinese stroke centers, of whom 221 patients were recruited. Demographics, clinical, radiological and treatment characteristics, safety outcomes, and functional outcomes were collected. Modified Rankin scale (mRS) score ≤ 2 at 90 days was defined as a good functional outcome. Results In our cohort, 79 patients (35.74%) were eventually found to have AF. Patients with AF were elder (70.08 ± 11.72 vs. 61.82 ± 13.48 years, p = 0.000) and less likely to be males (54.43 vs. 73.94%, p = 0.03). The significant reperfusion rate (modified thrombolysis in cerebral infarction 2b-3) was 73.42 and 83.80% in patients with and without AF, respectively ( p = 0.064). The good functional outcome (90-day modified Rankin scale: 0 to 2) rate was 39.24 and 44.37% in patients with and without AF, respectively ( p = 0.460) after adjusting multiple confounding factors. There was no difference in the presence of symptomatic intracerebral hemorrhage between the two groups (10.13 vs. 12.68%, p = 0.573). Conclusion Despite their older age, AF patients achieved similar outcomes as non-AF patients with anterior circulation occlusion treated with endovascular therapy.
    Type of Medium: Online Resource
    ISSN: 1663-4365
    URL: Article
    DOI: 10.3389/fnagi.2023.1160265
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2023
    detail.hit.zdb_id: 2558898-9
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  • 4
    Online Resource
    Online Resource
    Classification of inbound and outbound ships using convolutional neural networks
    Frontiers Media SA ; 2023
    In:  Frontiers in Marine Science Vol. 10 ( 2023-5-10)
    Details
    In: Frontiers in Marine Science, Frontiers Media SA, Vol. 10 ( 2023-5-10)
    Abstract: In general, a single scalar hydrophone cannot determine the orientation of an underwater acoustic target. However, through a study of sea trial experimental data, the authors found that the sound field interference structures of inbound and outbound ships differ owing to changes in the topography of the shallow continental shelf. Based on this difference, four different convolutional neural networks (CNNs), AlexNet, visual geometry group, residual network (ResNet), and dense convolutional network (DenseNet), are trained to classify inbound and outbound ships using only a single scalar hydrophone. Two datasets, a simulation and a sea trial, are used in the CNNs. Each dataset is divided into a training set and a test set according to the proportion of 40% to 60%. The simulation dataset is generated using underwater acoustic propagation software, with surface ships of different parameters (tonnage, speed, draft) modeled as various acoustic sources. The experimental dataset is obtained using submersible buoys placed near Qingdao Port, including 321 target ships. The ships in the dataset are labeled inbound or outbound using ship automatic identification system data. The results showed that the accuracy of the four CNNs based on the sea trial dataset in judging vessels’ inbound and outbound situations is above 90%, among which the accuracy of DenseNet is as high as 99.2%. This study also explains the physical principle of classifying inbound and outbound ships by analyzing the low-frequency analysis and recording diagram of the broadband noise radiated by the ships. This method can monitor ships entering and leaving ports illegally and with abnormal courses in specific sea areas.
    Type of Medium: Online Resource
    ISSN: 2296-7745
    URL: Article
    DOI: 10.3389/fmars.2023.1151817
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2023
    detail.hit.zdb_id: 2757748-X
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